Search Results - "Straub, S. G."

Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion by DANIEL, S, NODA, M, STRAUB, S. G, SHARP, G. W. G

“…Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion. S Daniel , M Noda , S G Straub and G W Sharp…”
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Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets by YAJIMA, H, KOMATSU, M, YAMADA, S, STRAUB, S. G, KANEKO, T, SATO, Y, YAMAUCHI, K, HASHIZUME, K, SHARP, G. W. G, AIZAWA, T

“…Cerulenin, an inhibitor of protein acylation, selectively attenuates nutrient stimulation of insulin release: a study in rat pancreatic islets. H Yajima , M…”
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Hyperinsulinism of infancy : The regulated release of insulin by KATP channel-independent pathways by STRAUB, Susanne G, COSGROVE, Karen E, LINDLEY, Keith J, SHARP, Geoffrey W. G, AYNSLEY-GREEN, Albert, DUNNE, Mark J, ÄMMÄLÄ, Carina, SHEPHERD, Ruth M, O'BRIEN, Rachel E, BARNES, Philippa D, KUCHINSKI, Na'Ama, CHAPMAN, Joanna C, SCHAEPPI, Michela, GLASER, Benjamin

“…Hyperinsulinism of infancy (HI) is a congenital defect in the regulated release of insulin from pancreatic beta-cells. Here we describe stimulus-secretion…”
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Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling by Komatsu, M., Schermerhorn, T., Noda, M., Straub, S. G., Aizawa, T., Sharp, G. W.

“…Augmentation of insulin release by glucose in the absence of extracellular Ca2+: new insights into stimulus-secretion coupling. M Komatsu , T Schermerhorn , M…”
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Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets by STRAUB, S. G, JAMES, R. F. L, DUNNE, M. J, SHARP, G. W. G

“…Glucose augmentation of mastoparan-stimulated insulin secretion in rat and human pancreatic islets. S G Straub , R F James , M J Dunne and G W Sharp Department…”
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Pituitary adenylate cyclase-activating peptide, carbachol, and glucose stimulate insulin release in the absence of an increase in intracellular Ca2 by Komatsu, M, Schermerhorn, T, Straub, S G, Sharp, G W

“…Insulin secretion from the pancreatic beta cell line HIT-T15 was examined under conditions in which the elevation of intracellular free Ca2+ concentration…”
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Vasoactive intestinal polypeptide-augmented insulin release : actions on ionic fluxes and electrical activity of mouse islets by WAHL, M. A, STRAUB, S. G, AMMON, H. P. T

“…Vasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release. To obtain more detailed information on its mode of action on…”
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The alpha2-adrenergic receptor is more effective than the galanin receptor in activating G-proteins in RINm5F beta-cell membranes by Gillison, S L, Straub, S G, Sharp, G W

“…The alpha2-adrenergic receptor is more effective than the galanin receptor in activating G-proteins in RINm5F beta-cell membranes. S L Gillison , S G Straub…”
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Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets by Straub, S G, James, R F, Dunne, M J, Sharp, G W

“…Glucose activates both K(ATP) channel-dependent and K(ATP) channel-independent signaling pathways in human islets. S G Straub , R F James , M J Dunne and G W…”
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A Wortmannin-sensitive Signal Transduction Pathway Is Involved in the Stimulation of Insulin Release by Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-activating Polypeptide (∗) by Straub, Susanne G., Sharp, Geoffrey W.G.

“…Vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide-27 (PACAP-27), and PACAP-38 stimulated insulin release with EC50…”
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Picomole analysis of alkali metals by flameless atomic absorption spectrophotometry by Wingo, Charles S., Bixler, Geraldine B., Park, Chan Hyung, Straub, Scott G.

“…The chemical analysis of sodium and potassium concentrations in picoliter to nanoliter quantities of physiologic fluid is critical to the understanding of…”
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The Calcimimetic R-467 Potentiates Insulin Secretion in Pancreatic β Cells by Activation of a Nonspecific Cation Channel by Straub, Susanne G., Kornreich, Bruce, Oswald, Robert E., Nemeth, Edward F., Sharp, Geoffrey W.G.

“…The extracellular, G protein-linked Ca2+-sensing receptor (CaSR), first identified in the parathyroid gland, is expressed in several tissues and cells and can…”
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Progesterone inhibits insulin secretion by a membrane delimited, non-genomic action by Straub, S G, Sharp, G W, Meglasson, M D, De Souza, C J

“…In rat islets, progesterone caused a prompt concentration-dependent inhibition of glucose-stimulated insulin release with an IC50 of 10 microM at 8.4mM…”
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Augmentation of insulin release by glucose in the absence of extracellular Ca2+ : New insights into stimulus-secretion coupling by KOMATSU, M, SCHERMERHORN, T, NODA, M, STRAUB, S. G, AIZAWA, T, SHARP, G. W. G

“…Glucose stimulates insulin secretion in the pancreatic beta-cell by means of a synergistic interaction between at least two signaling pathways. One, the K(ATP)…”
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Mechanisms of action of VIP and PACAP in the stimulation of insulin release by Straub, S G, Sharp, G W

“…VIP and PACAP stimulate insulin release by interaction with the VIP-2/PACAP-3 receptor on the beta cell. Activation of the receptor results in Gs-mediated…”
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Glucose-stimulated signaling pathways in biphasic insulin secretion by Straub, Susanne G., Sharp, Geoffrey W. G.

“…Glucose‐stimulated biphasic insulin secretion involves at least two signaling pathways, the KATP channel‐dependent and KATP channel‐independent pathways,…”
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Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion by BRATANOVA-TOCHKOVA, Troitza K, CHENG, Haiying, DANIEL, Samira, GUNAWARDANA, Subhadra, LIU, Yi-Jia, MULVANEY-MUSA, Jennifer, SCHERMERHORN, Thomas, STRAUB, Susanne G, YAJIMA, Hiroki, SHARP, Geoffrey W. G

“…The insulin secretory response by pancreatic beta-cells to an acute "square wave" stimulation by glucose is characterized by a first phase that occurs promptly…”
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Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets by STRAUB, Susanne G, SHANMUGAM, Geetha, SHARP, Geoffrey W. G

“…Stimulation of Insulin Release by Glucose Is Associated With an Increase in the Number of Docked Granules in the β-Cells of Rat Pancreatic Islets Susanne G…”
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Hypothesis: one rate-limiting step controls the magnitude of both phases of glucose-stimulated insulin secretion by Straub, Susanne G, Sharp, Geoffrey W G

“…The biphasic secretory response of pancreatic beta-cells to abrupt and sustained exposure to glucose is well documented. Some of the ATP-sensitive K(+)…”
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Glucose-dependent insulinotropic polypeptide stimulates insulin secretion via increased cyclic AMP and [Ca2+]1 and a wortmannin-sensitive signalling pathway by Straub, S G, Sharp, G W

“…The effect of wortmannin, a fungal metabolite which is known to inhibit phosphatidylinositol 3-kinase (PI3-kinase) at low concentrations, has been examined for…”
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