Search Results - "Straub, Adam C"

STING inhibition enables efficient plasmid-based gene expression in primary vascular cells: A simple and cost-effective transfection protocol by Yuan, Shuai, Straub, Adam C

“…Plasmid transfection in cells is widely employed to express exogenous proteins, offering valuable mechanistic insight into their function(s). However, plasmid…”
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KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis by Shankman, Laura S, Gomez, Delphine, Cherepanova, Olga A, Salmon, Morgan, Alencar, Gabriel F, Haskins, Ryan M, Swiatlowska, Pamela, Newman, Alexandra A C, Greene, Elizabeth S, Straub, Adam C, Isakson, Brant, Randolph, Gwendalyn J, Owens, Gary K

“…A high percentage of smooth muscle cells in atherosclerotic lesions lose expression of smooth muscle marker proteins and acquire the phenotype of other cell…”
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The impact of xanthine oxidase (XO) on hemolytic diseases by Schmidt, Heidi M, Kelley, Eric E, Straub, Adam C

“…Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions with…”
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Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling by Rahaman, Mizanur M, Nguyen, Anh T, Miller, Megan P, Hahn, Scott A, Sparacino-Watkins, Courtney, Jobbagy, Soma, Carew, Nolan T, Cantu-Medellin, Nadiezhda, Wood, Katherine C, Baty, Catherine J, Schopfer, Francisco J, Kelley, Eric E, Gladwin, Mark T, Martin, Emil, Straub, Adam C

“…RATIONALE:Soluble guanylate cyclase (sGC) heme iron, in its oxidized state (Fe), is desensitized to NO and limits cGMP production needed for downstream…”
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Neuromuscular dysfunction and pathogenesis in triosephosphate isomerase deficiency by Myers, Tracey D., Li, Yizhi, Taiclet, Stefanie, Cabada-Aguirre, Paulina, Kuti, Emily, McClure, Kaitlin, Blanchard, Christopher, Wolosowicz, Marta, Homanics, Gregg E., Straub, Adam C., Meriney, Stephen D., Palladino, Michael J.

“…Triosephosphate isomerase deficiency (TPI Df) is a rare multisystem disorder with severe neuromuscular symptoms which arises exclusively from mutations within…”
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Pannexin1 Regulates α1-Adrenergic Receptor– Mediated Vasoconstriction by Billaud, Marie, Lohman, Alexander W, Straub, Adam C, Looft-Wilson, Robin, Johnstone, Scott R, Araj, Christina A, Best, Angela K, Chekeni, Faraaz B, Ravichandran, Kodi S, Penuela, Silvia, Laird, Dale W, Isakson, Brant E

“…RATIONALE:The coordination of vascular smooth muscle cell constriction plays an important role in vascular function, such as regulation of blood pressure;…”
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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death by Carew, Nolan T, Schmidt, Heidi M, Yuan, Shuai, Galley, Joseph C, Hall, Robert, Altmann, Helene M, Hahn, Scott A, Miller, Megan P, Wood, Katherine C, Gabris, Bethann, Stapleton, Margaret C, Hartwick, Sean, Fazzari, Marco, Wu, Yijen L, Trebak, Mohamed, Kaufman, Brett A, McTiernan, Charles F, Schopfer, Francisco J, Navas, Placido, Thibodeau, Patrick H, McNamara, Dennis M, Salama, Guy, Straub, Adam C

“…Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes;…”
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Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells by Emrich, Scott M, Yoast, Ryan E, Zhang, Xuexin, Fike, Adam J, Wang, Yin-Hu, Bricker, Kristen N, Tao, Anthony Y, Xin, Ping, Walter, Vonn, Johnson, Martin T, Pathak, Trayambak, Straub, Adam C, Feske, Stefan, Rahman, Ziaur S M, Trebak, Mohamed

“…The essential role of store-operated Ca entry (SOCE) through Ca release-activated Ca (CRAC) channels in T cells is well established. In contrast, the…”
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Nrf2 Activation With CDDO-Methyl Promotes Beneficial and Deleterious Clinical Effects in Transgenic Mice With Sickle Cell Anemia by Ihunnah, Chibueze A, Ghosh, Samit, Hahn, Scott, Straub, Adam C, Ofori-Acquah, Solomon F

“…Activation of Nrf2, a major transcription factor that drives the antioxidant defense system, is an emerging therapeutic strategy in Sickle Cell Disease (SCD)…”
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Fatty acid nitroalkenes – Multi-target agents for the treatment of sickle cell disease by Chowdhury, Fabliha A., Colussi, Nicole, Sharma, Malini, Wood, Katherine C., Xu, Julia Z., Freeman, Bruce A., Schopfer, Francisco J., Straub, Adam C.

“…Sickle cell disease (SCD) is a hereditary hematological disease with high morbidity and mortality rates worldwide. Despite being monogenic, SCD patients…”
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Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide by Straub, Adam C, Clark, Katherine A, Ross, Mark A, Chandra, Ashwin G, Li, Song, Gao, Xiang, Pagano, Patrick J, Stolz, Donna B, Barchowsky, Aaron

“…Environmental arsenic exposure, through drinking contaminated water, is a significant risk factor for developing vascular diseases and is associated with liver…”
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The Role of Nitric Oxide during Sonoreperfusion of Microvascular Obstruction by Yu, Francois T H, Chen, Xucai, Straub, Adam C, Pacella, John J

“…Microembolization during PCI for acute myocardial infarction can cause microvascular obstruction . MVO severely limits the success of reperfusion therapies, is…”
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Hemin and iron increase synthesis and trigger export of xanthine oxidoreductase from hepatocytes to the circulation by DeVallance, Evan R., Schmidt, Heidi M., Seman, Madison, Lewis, Sara E., Wood, Katherine C., Vickers, Schuyler D., Hahn, Scott A., Velayutham, Murugesan, Hileman, Emily A., Vitturi, Dario A., Leonardi, Roberta, Straub, Adam C., Kelley, Eric E.

“…We recently reported a previously unknown salutary role for xanthine oxidoreductase (XOR) in intravascular heme overload whereby hepatocellular export of XOR…”
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Release of hepatic xanthine oxidase (XO) to the circulation is protective in intravascular hemolytic crisis by Schmidt, Heidi M., DeVallance, Evan R., Lewis, Sara E., Wood, Katherine C., Annarapu, Gowtham K., Carreño, Mara, Hahn, Scott A., Seman, Madison, Maxwell, Brooke A., Hileman, Emily A., Xu, Julia Z., Velayutham, Murugesan, Geldenhuys, Werner J., Vitturi, Dario A., Shiva, Sruti, Kelley, Eric E., Straub, Adam C.

“…Xanthine oxidase (XO) catalyzes the catabolism of hypoxanthine to xanthine and xanthine to uric acid, generating oxidants as a byproduct. Importantly, XO…”
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Decoding the role of SOD2 in sickle cell disease by Dosunmu-Ogunbi, Atinuke M., Wood, Katherine C., Novelli, Enrico M., Straub, Adam C.

“…Sickle cell disease (SCD) is an inherited hemoglobinopathy caused by a single point mutation in the β-globin gene. As a consequence, deoxygenated hemoglobin…”
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Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation by Durgin, Brittany G, Hahn, Scott A, Schmidt, Heidi M, Miller, Megan P, Hafeez, Neha, Mathar, Ilka, Freitag, Daniel, Sandner, Peter, Straub, Adam C

“…Nitric oxide (NO) regulates blood pressure (BP) by binding the reduced heme iron (Fe2+) in soluble guanylyl cyclase (sGC) and relaxing vascular smooth muscle…”
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Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation by Yuan, Shuai, Hahn, Scott A., Miller, Megan P., Sanker, Subramaniam, Calderon, Michael J., Sullivan, Mara, Dosunmu-Ogunbi, Atinuke M., Fazzari, Marco, Li, Yao, Reynolds, Michael, Wood, Katherine C., St Croix, Claudette M., Stolz, Donna, Cifuentes-Pagano, Eugenia, Navas, Placido, Shiva, Sruti, Schopfer, Francisco J., Pagano, Patrick J., Straub, Adam C.

“…NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2•-. The ratio of NOX4-derived H2O2 and…”
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Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors by Sangwung, Panjamaporn, Zhou, Guangjin, Lu, Yuan, Liao, Xudong, Wang, Benlian, Mutchler, Stephanie M, Miller, Megan, Chance, Mark R, Straub, Adam C, Jain, Mukesh K

“…Hemoglobin subunit alpha (HBA) expression in endothelial cells (ECs) has recently been shown to control vascular tone and function. We sought to elucidate the…”
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CD47 Promotes Age-Associated Deterioration in Angiogenesis, Blood Flow and Glucose Homeostasis by Ghimire, Kedar, Li, Yao, Chiba, Takuto, Julovi, Sohel M, Li, Jennifer, Ross, Mark A, Straub, Adam C, O'Connell, Philip J, Rüegg, Curzio, Pagano, Patrick J, Isenberg, Jeffrey S, Rogers, Natasha M

“…The aged population is currently at its highest level in human history and is expected to increase further in the coming years. In humans, aging is accompanied…”
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Expression of pannexin isoforms in the systemic murine arterial network by Lohman, Alexander W, Billaud, Marie, Straub, Adam C, Johnstone, Scott R, Best, Angela K, Lee, Monica, Barr, Kevin, Penuela, Silvia, Laird, Dale W, Isakson, Brant E

“…Pannexins (Panx) form ATP release channels and it has been proposed that they play an important role in the regulation of vascular tone. However, distribution…”
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