Search Results - "Stratton, Matthew S."

Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA by Stratton, Matthew S., Lin, Charles Y., Anand, Priti, Tatman, Philip D., Ferguson, Bradley S., Wickers, Sean T., Ambardekar, Amrut V., Sucharov, Carmen C., Bradner, James E., Haldar, Saptarsi M., McKinsey, Timothy A.

“…BRD4 governs pathological cardiac gene expression by binding acetylated chromatin, resulting in enhanced RNA polymerase II (Pol II) phosphorylation and…”
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Discovery of Novel Small Molecule Inhibitors of Cardiac Hypertrophy Using High Throughput, High Content Imaging by Reid, Brian G, Stratton, Matthew S, Bowers, Samantha, Cavasin, Maria A, Demos-Davies, Kimberley M, Susano, Isidro, McKinsey, Timothy A

“…Abstract Chronic cardiac hypertrophy is maladaptive and contributes to the pathogenesis of heart failure. The objective of this study was to identify small…”
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BRD4 inhibition for the treatment of pathological organ fibrosis by Stratton, Matthew S, Haldar, Saptarsi M, McKinsey, Timothy A

“…Fibrosis is defined as excess deposition of extracellular matrix, resulting in tissue scarring and organ dysfunction. It is estimated that 45% of deaths in the…”
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Embryonic GABAB Receptor Blockade Alters Cell Migration, Adult Hypothalamic Structure, and Anxiety- and Depression-Like Behaviors Sex Specifically in Mice by Stratton, Matthew S., Staros, Michelle, Budefeld, Tomaz, Searcy, Brian T., Nash, Connor, Eitel, Chad, Carbone, David, Handa, Robert J., Majdic, Gregor, Tobet, Stuart A.

“…Neurons of the paraventricular nucleus of the hypothalamus (PVN) regulate the hypothalamic- pituitary-adrenal (HPA) axis and the autonomic nervous system…”
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Embryonic GABA(B) receptor blockade alters cell migration, adult hypothalamic structure, and anxiety- and depression-like behaviors sex specifically in mice by Stratton, Matthew S, Staros, Michelle, Budefeld, Tomaz, Searcy, Brian T, Nash, Connor, Eitel, Chad, Carbone, David, Handa, Robert J, Majdic, Gregor, Tobet, Stuart A

“…Neurons of the paraventricular nucleus of the hypothalamus (PVN) regulate the hypothalamic- pituitary-adrenal (HPA) axis and the autonomic nervous system…”
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Epigenetics and vascular diseases by Stratton, Matthew S., Farina, Floriana Maria, Elia, Leonardo

“…Cardiovascular disease remains the number one cause of death and disability worldwide despite significant improvements in diagnosis, prevention, and early…”
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Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease by Evans, Levi W, Stratton, Matthew S, Ferguson, Bradley S

“…Covering: up to 2020Chronic, low-grade inflammation is linked to aging and has been termed "inflammaging". Inflammaging is considered a key contributor to the…”
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Epigenetic regulation of cardiac fibrosis by Stratton, Matthew S, McKinsey, Timothy A

“…Abstract Fibrosis is defined as excess deposition of extracellular matrix (ECM), resulting in tissue scarring and organ dysfunction. In the heart, fibrosis may…”
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Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation by Stratton, Matthew S, Bagchi, Rushita A, Felisbino, Marina B, Hirsch, Rachel A, Smith, Harrison E, Riching, Andrew S, Enyart, Blake Y, Koch, Keith A, Cavasin, Maria A, Alexanian, Michael, Song, Kunhua, Qi, Jun, Lemieux, Madeleine E, Srivastava, Deepak, Lam, Maggie P.Y, Haldar, Saptarsi M, Lin, Charles Y, McKinsey, Timothy A

“…RATIONALE:Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in preclinical models of heart failure…”
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Estrogen Receptor-β Agonists Modulate T-Lymphocyte Activation and Ameliorate Left Ventricular Remodeling During Chronic Heart Failure by Rosenzweig, Rachel, Kumar, Vinay, Gupta, Sahil, Bermeo-Blanco, Oscar, Stratton, Matthew S., Gumina, Richard J., Bansal, Shyam S.

“…CD4 T cells temporally transition from protective to pathological during ischemic heart failure (HF; 8 weeks postmyocardial infarction). Cellular mechanisms…”
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Protein acetylation in cardiac aging by Francois, Ashley, Canella, Alessandro, Marcho, Lynn M., Stratton, Matthew S.

“…Biological aging is attributed to progressive dysfunction in systems governing genetic and metabolic integrity. At the cellular level, aging is evident by…”
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BET acetyl-lysine binding proteins control pathological cardiac hypertrophy by Spiltoir, Jessica I, Stratton, Matthew S, Cavasin, Maria A, Demos-Davies, Kim, Reid, Brian G, Qi, Jun, Bradner, James E, McKinsey, Timothy A

“…Abstract Cardiac hypertrophy is an independent predictor of adverse outcomes in patients with heart failure, and thus represents an attractive target for novel…”
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Molecular signature of cardiac remodeling associated with Polymerase Gamma mutation by Gorr, Matthew W., Francois, Ashley, Marcho, Lynn M., Saldana, Ty, McGrail, Erin, Sun, Nuo, Stratton, Matthew S.

“…Metabolic function/dysfunction is central to aging biology. This is well illustrated by the Polymerase Gamma (POLG) mutant mouse where a key residue of the…”
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Microfibrillar-Associated Protein 4 Regulates Stress-Induced Cardiac Remodeling by Dorn, Lisa E., Lawrence, William, Petrosino, Jennifer M., Xu, Xianyao, Hund, Thomas J., Whitson, Bryan A., Stratton, Matthew S., Janssen, Paul M. L., Mohler, Peter J., Schlosser, Anders, Sorensen, Grith L., Accornero, Federica

“…[Figure: see text]…”
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Reply: Aortic Valve Remodeling in CF-LVAD: Beyond the Arterial Wall by Ambardekar, Amrut V., Stratton, Matthew S., Weiser-Evans, Mary C.M., Moulton, Karen S., McKinsey, Timothy A.

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Matrix-Degrading Enzyme Expression and Aortic Fibrosis During Continuous-Flow Left Ventricular Mechanical Support by Ambardekar, Amrut V., Stratton, Matthew S., Dobrinskikh, Evgenia, Hunter, Kendall S., Tatman, Philip D., Lemieux, Madeleine E., Cleveland, Joseph C., Tuder, Rubin M., Weiser-Evans, Mary C.M., Moulton, Karen S., McKinsey, Timothy A.

“…The effects of nonphysiological flow generated by continuous-flow (CF) left ventricular assist devices (LVADs) on the aorta remain poorly understood. The…”
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p38α: A Profibrotic Signaling Nexus by Stratton, Matthew S, Koch, Keith A, McKinsey, Timothy A

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Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophy by Stratton, Matthew S, McKinsey, Timothy A

“…Acetylation of lysine residues within nucleosomal histone tails provides a crucial mechanism for epigenetic control of gene expression. Acetyl groups are…”
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Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes by Clements, Richard T., Terentyeva, Radmila, Hamilton, Shanna, Janssen, Paul M. L., Roder, Karim, Martin, Benjamin Y., Perger, Fruzsina, Schneider, Timothy, Nichtova, Zuzana, Das, Anindhya S., Veress, Roland, Lee, Beth S., Kim, Do-Gyoon, Koren, Gideon, Stratton, Matthew S., Csordas, Gyorgy, Accornero, Federica, Belevych, Andriy E., Gyorke, Sandor, Terentyev, Dmitry

“…Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+ release is essential to boost energy production in ventricular…”
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DUSP5-mediated inhibition of smooth muscle cell proliferation suppresses pulmonary hypertension and right ventricular hypertrophy by Ferguson, Bradley S, Wennersten, Sara A, Demos-Davies, Kimberly M, Rubino, Marcello, Robinson, Emma L, Cavasin, Maria A, Stratton, Matthew S, Kidger, Andrew M, Hu, Tianjing, Keyse, Stephen M, McKnight, Robert A, Lane, Robert H, Nozik, Eva S, Weiser-Evans, Mary C M, McKinsey, Timothy A

“…Pulmonary hypertension (PH) is associated with structural remodeling of pulmonary arteries (PAs) because of excessive proliferation of fibroblasts, endothelial…”
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