Search Results - "Stratikos, E."

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA‐C associated antigenic epitope in vitro by Niepiekło‐Miniewska, W., Mpakali, A., Stratikos, E., Matusiak, Ł., Narbutt, J., Lesiak, A., Kuna, P., Wilczyńska, K., Nowak, I., Wiśniewski, A., Zwolińska, K., Ponińska, J., Płoski, R., Szepietowski, J.C., Kuśnierczyk, P.

“…Background Atopic dermatitis (AD) is a common inflammatory skin disease of complex aetiology, with interactions between susceptibility genes and environmental…”
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Major Proteinase Movement upon Stable Serpin-Proteinase Complex Formation by Stratikos, Efstratios, Peter G. W. Gettins

“…To determine whether formation of the stable complex between a serpin and a target proteinase involves a major translocation of the proteinase from its initial…”
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Insights from structure-function analysis of naturally occurring apolipoprotein A-I mutants L144R, A164S and L178P on their role on HDL levels and cardiovascular risk by Gkolfinopoulou, C., Soukou, F., Stratikos, E., Chroni, A.

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Recombinant human pigment epithelium‐derived factor (PEDF): Characterization of PEDF overexpressed and secreted by eukaryotic cells by Stratikos, Efstratios, Alberdi, Elena, Gettins, Peter G.W., Becerra, S. Patricia

“…Pigment epithelium‐derived factor (PEDF) is a serpin found in the interphotoreceptor matrix of the eye, which, although not a proteinase inhibitor, possesses a…”
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Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1 by Nguyen, Tina T, Chang, Shih-Chung, Evnouchidou, Irini, York, Ian A, Zikos, Christos, Rock, Kenneth L, Goldberg, Alfred L, Stratikos, Efstratios, Stern, Lawrence J

“…Endoplasmic reticulum aminopeptidase 1 (ERAP1) has a crucial role in antigen presentation because it trims peptide ligands to 8–10 residues so that they fit…”
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Formation of the Covalent Serpin-Proteinase Complex Involves Translocation of the Proteinase by More Than 70 angstrom and Full Insertion of the Reactive Center Loop into β -sheet A by Stratikos, Efstratios, Peter G. W. Gettins

“…To determine the location of the proteinase in the covalent serpin-proteinase complex we prepared seven single-cysteine-containing variants of the Pittsburgh…”
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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A by Stratikos, E, Gettins, P G

“…To determine the location of the proteinase in the covalent serpin-proteinase complex we prepared seven single-cysteine-containing variants of the Pittsburgh…”
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Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain by Stratikos, Efstratios, Wiley, Don C, Stern, Lawrence J

“…The class II MHC homolog HLA-DM catalyzes exchange of peptides bound to class II MHC proteins, and is an important component of the Ag presentation machinery…”
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Crystal structure of an aminopeptidase important in antigenic peptide processing by Birtley, J. R., Saridakis, E., Stratikos, E., Mavridis, I. M.

“…Abstract only…”
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Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis by Stratikos, Efstratios, Mosyak, Lidia, Zaller, Dennis M, Wiley, Don C

“…Human histocompatibility leukocyte antigen (HLA)-DM is a major histocompatibility complex (MHC)-like protein that catalyzes exchange of antigenic peptides from…”
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Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh by Stratikos, E, Gettins, P G

“…To probe the covalent serpin-proteinase complex, we used wild-type and 4 new single cysteine variants (T85C, S121C, D159C, and D298C) of alpha1-proteinase…”
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Change in Environment of the P1 Side Chain upon Progression from the Michaelis Complex to the Covalent Serpin−Proteinase Complex by Futamura, Akiko, Stratikos, Efstratios, Olson, Steven T, Gettins, Peter G. W

“…Serpins inhibit proteinases by forming a kinetically trapped intermediate during a suicide substrate inhibition reaction. To determine whether the kinetic trap…”
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