Search Results - "Strathearn, Katherine E."

Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis by Gitler, Aaron D, Bevis, Brooke J, Shorter, James, Strathearn, Katherine E, Hamamichi, Shusei, Su, Linhui Julie, Caldwell, Kim A, Caldwell, Guy A, Rochet, Jean-Christophe, McCaffery, J. Michael, Barlowe, Charles, Lindquist, Susan

“…α-Synuclein (α-syn), a protein of unknown function, is the most abundant protein in Lewy bodies, the histological hallmark of Parkinson's disease (PD). In…”
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Acrolein-mediated neuronal cell death and alpha-synuclein aggregation: Implications for Parkinson's disease by Ambaw, Abeje, Zheng, Lingxing, Tambe, Mitali A., Strathearn, Katherine E., Acosta, Glen, Hubers, Scott A., Liu, Fang, Herr, Seth A., Tang, Jonathan, Truong, Alan, Walls, Elwood, Pond, Amber, Rochet, Jean-Christophe, Shi, Riyi

“…Growing evidence suggests that oxidative stress plays a critical role in neuronal destruction characteristic of Parkinson's disease (PD). However, the…”
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Two C-terminal sequence variations determine differential neurotoxicity between human and mouse α-synuclein by Landeck, Natalie, Strathearn, Katherine E, Ysselstein, Daniel, Buck, Kerstin, Dutta, Sayan, Banerjee, Siddhartha, Lv, Zhengjian, Hulleman, John D, Hindupur, Jagadish, Lin, Li-Kai, Padalkar, Sonal, Stanciu, Lia A, Lyubchenko, Yuri L, Kirik, Deniz, Rochet, Jean-Christophe

“…α-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including Parkinson's disease (PD)…”
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Protective Effects of Polyphenol-Rich Extracts against Neurotoxicity Elicited by Paraquat or Rotenone in Cellular Models of Parkinson's Disease by Tambe, Mitali A, de Rus Jacquet, Aurélie, Strathearn, Katherine E, Hensel, Jennifer A, Colón, Bryce D, Chandran, Aswathy, Yousef, Gad G, Grace, Mary H, Ferruzzi, Mario G, Wu, Qingli, Simon, James E, Lila, Mary Ann, Rochet, Jean-Christophe

“…Parkinson's disease (PD) is a neurodegenerative disorder involving motor symptoms caused by a loss of dopaminergic neurons in the substantia nigra region of…”
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Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson's disease by STRATHEARN, Katherine E, YOUSEF, Gad G, GRACE, Mary H, ROY, Susan L, TAMBE, Mitali A, FERRUZZI, Mario G, WU, Qing-Li, SIMON, James E, LILA, Mary Ann, ROCHET, Jean-Christophe

“…Neuropathological evidence indicates that dopaminergic cell death in Parkinson’s disease (PD) involves impairment of mitochondrial complex I, oxidative stress,…”
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α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity by Gitler, Aaron D, Cooper, Antony A, Rochet, Jean-Christophe, Strathearn, Katherine E, Hill, Kathryn J, Chesi, Alessandra, Geddie, Melissa L, Caldwell, Kim A, Lindquist, Susan, Hamamichi, Shusei, Caldwell, Guy A

“…Susan Lindquist and colleagues report a genetic interaction between α-synuclein and the ortholog of human ATP13A2 (PARK9) in yeast, two genes that when mutated…”
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Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease by Outeiro, Tiago Fleming, Kontopoulos, Eirene, Altmann, Stephen M, Kufareva, Irina, Strathearn, Katherine E, Amore, Allison M, Volk, Catherine B, Maxwell, Michele M, Rochet, Jean-Christophe, McLean, Pamela J, Young, Anne B, Abagyan, Ruben, Feany, Mel B, Hyman, Bradley T, Kazantsev, Aleksey G

“…The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We…”
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α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models by Cooper, Antony A, Gitler, Aaron D, Cashikar, Anil, Haynes, Cole M, Hill, Kathryn J, Bhullar, Bhupinder, Liu, Kangning, Xu, Kexiang, Strathearn, Katherine E, Liu, Fang, Cao, Songsong, Caldwell, Kim A, Caldwell, Guy A, Marsischky, Gerald, Kolodner, Richard D, LaBaer, Joshua, Rochet, Jean-Christophe, Bonini, Nancy M, Lindquist, Susan

“…Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in…”
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Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation by Outeiro, Tiago Fleming, Klucken, Jochen, Strathearn, Katherine E., Liu, Fang, Nguyen, Paul, Rochet, Jean-Christophe, Hyman, Bradley T., McLean, Pamela J.

“…Protein misfolding and inclusion formation are common events in neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD) or…”
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Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study by DUMITRIU, Alexandra, PACHECO, Chris D, WILK, Jemma B, STRATHEARN, Katherine E, LATOURELLE, Jeanne C, GOLDWURM, Stefano, PEZZOLI, Gianni, ROCHET, Jean-Christophe, LINDQUIST, Susan, MYERS, Richard H

“…Although family history is a well-established risk factor for Parkinson's disease (PD), fewer than 5% of PD cases can be attributed to known genetic mutations…”
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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models by Su, Linhui Julie, Auluck, Pavan K, Outeiro, Tiago Fleming, Yeger-Lotem, Esti, Kritzer, Joshua A, Tardiff, Daniel F, Strathearn, Katherine E, Liu, Fang, Cao, Songsong, Hamamichi, Shusei, Hill, Kathryn J, Caldwell, Kim A, Bell, George W, Fraenkel, Ernest, Cooper, Antony A, Caldwell, Guy A, McCaffery, J Michael, Rochet, Jean-Christophe, Lindquist, Susan

“…alpha-Synuclein (alpha-syn) is a small lipid-binding protein involved in vesicle trafficking whose function is poorly characterized. It is of great interest to…”
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Neuroprotective effects of anthocyanin- and proanthocyanidin-rich extracts in cellular models of Parkinson׳s disease by Strathearn, Katherine E, Yousef, Gad G, Grace, Mary H, Roy, Susan L, Tambe, Mitali A, Ferruzzi, Mario G, Wu, Qing-Li, Simon, James E, Lila, Mary Ann, Rochet, Jean-Christophe

“…Abstract Neuropathological evidence indicates that dopaminergic cell death in Parkinson׳s disease (PD) involves impairment of mitochondrial complex I,…”
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Two C-terminal sequence variations determine differential neurotoxicity between human and mouse [alpha]-synuclein by Landeck, Natalie, Strathearn, Katherine E, Ysselstein, Daniel, Buck, Kerstin, Dutta, Sayan, Banerjee, Siddhartha, Lv, Zhengjian, Hulleman, John D, Hindupur, Jagadish, Lin, Li-Kai, Padalkar, Sonal, Stanciu, Lia A, Lyubchenko, Yuri L, Kirik, Deniz, Rochet, Jean-Christophe

“…Background [alpha]-Synuclein (aSyn) aggregation is thought to play a central role in neurodegenerative disorders termed synucleinopathies, including…”
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[alpha]-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity by Gitler, Aaron D, Chesi, Alessandra, Geddie, Melissa L, Strathearn, Katherine E, Hamamichi, Shusei, Hill, Kathryn J, Caldwell, Kim A, Caldwell, Guy A, Cooper, Antony A, Rochet, Jean-Christophe, Lindquist, Susan

“…Several features of this toxicity, including production of reactive oxygen species (ROS), lipid droplet accumulation and vesicle trafficking defects, are…”
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Oc-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity by GITLER, Aaron D, CHESI, Alessandra, LINDQUIST, Susan, GEDDIE, Melissa L, STRATHEARN, Katherine E, HAMAMICHI, Shusei, HILL, Kathryn J, CALDWELL, Kim A, CALDWELL, Guy A, COOPER, Antony A, ROCHET, Jean-Christophe

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The Parkinson's disease protein ¿-synuclein disrupts cellular Rab homeostasis by Gitler, Aaron D, Bevis, Brooke J, Shorter, James, Strathearn, Katherine E, Hamamichi, Shusei, Su, Linhui Julie, Caldwell, Kim A, Caldwell, Guy A, Rochet, Jean-Christophe, McCaffery, J Michael, Barlowe, Charles, Lindquist, Susan

“…α-Synuclein (α-syn), a protein of unknown function, is the most abundant protein in Lewy bodies, the histological hallmark of Parkinson's disease (PD). In…”
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Small heat shock proteins protect against {alpha}-synuclein-induced toxicity and aggregation by Outeiro, Tiago Fleming, Klucken, Jochen, Strathearn, Katherine E., Liu Fang, Nguyen, Paul, Rochet, Jean-Christophe, Hyman, Bradley T., McLean, Pamela J.

“…Protein misfolding and inclusion formation are common events in neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD) or…”
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Role of alpha-synuclein primary structure and oxidative stress in Parkinson's disease pathology by Strathearn, Katherine E

“…Parkinson's disease (PD) is a neurodegenerative disorder which affects approximately 1% of the population 65 years of age and younger. Two classic hallmarks of…”
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Sirtuin 2 Inhibitors Rescue [alpha]-Synuclein-Mediated Toxicity in Models of Parkinson's Disease by Outeiro, Tiago Fleming, Kontopoulos, Eirene, Altmann, Stephen M, Kufareva, Irina, Strathearn, Katherine E, Amore, Allison M, Volk, Catherine B, Maxwell, Michele M, Rochet, Jean-Christophe, McLean, Pamela J, Young, Anne B, Abagyan, Ruben, Feany, Mel B

“…The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We…”
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{alpha}-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models by Cooper, Antony A, Gitler, Aaron D, Cashikar, Anil, Haynes, Cole M, Hill, Kathryn J, Bhullar, Bhupinder, Liu, Kangning, Xu, Kexiang, Strathearn, Katherine E, Liu, Fang, Cao, Songsong, Caldwell, Kim A, Caldwell, Guy A, Marsischky, Gerald, Kolodner, Richard D, LaBaer, Joshua, Rochet, Jean-Christophe, Bonini, Nancy M, Lindquist, Susan

“…Alpha-synuclein ({alpha}Syn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells…”
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