Search Results - "Stratford, I.J"

371 TRANSLATING CHEMICAL CONCEPTS INTO CLINICAL TREATMENTS: NOT A QUICK FIX by Stratford, I.J

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Evaluating the efficiency of hyaluronic acid for specific tumour targeting by Spadea, A, de la Rosa, J.M. Rios, Mehibel, M, Marianne, A, Tirelli, N, Stratford, I.J

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Emerging Opportunities for the Combination of Molecularly Targeted Drugs with Radiotherapy by Searle, E.J, Illidge, T.M, Stratford, I.J

“…Abstract Recent drug discovery developments in the field of small molecule targeted agents have led to much interest in combining these with radiotherapy…”
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Radiotherapy Research Priorities for the UK by Maughan, T.S, Illidge, T.M, Hoskin, P, McKenna, W.G, Brunner, T.B, Stratford, I.J, Harrington, K.J, Plummer, R, Billingham, L.J, Nutting, C, Burnet, N.G, Mackay, R.I, Oliver, A, Young, C, Chan, C.S.K

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Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection by Oliver, R.J., Woodwards, R.T.M., Sloan, P., Thakker, N.S., Stratford, I.J., Airley, R.E.

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135 INVITED Combining molecular targeted agents with radiotherapy by Wedge, S.R, Williams, K.J, Stratford, I.J

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Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening by MCNALLY, V. A, GBAJ, A, DOUGLAS, K. T, STRATFORD, I. J, JAFFAR, M, FREEMAN, S, BRYCE, R. A

“…Structure-based computational screening of the National Cancer Institute database of anticancer compounds identified novel non-nucleobase-derived inhibitors of…”
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855 - Evaluating the efficiency of hyaluronic acid for specific tumour targeting by Spadea, A., de la Rosa, J.M. Rios, Mehibel, M., Marianne, A., Tirelli, N., Stratford, I.J.

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20 Inaugural eortc session lecture: New hypoxia targets in the arena by Stratford, I.J.

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Modification of energy metabolism and radiation response of a murine tumour by changes in nitric oxide availability by Wood, P J, Stratford, I J, Adams, G E, Szabo, C, Thiemermann, C, Vane, J R

“…The nitric oxide donor, SIN-1 and nitric oxide synthase inhibitor, nitro-L-arginine were examined for their effects on energy metabolism using 31P magnetic…”
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HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells by MAXWELL, P. J, GALLAGHER, R, SEATON, A, WILSON, C, SCULLIN, P, PETTIGREW, J, STRATFORD, I. J, WILLIAMS, K. J, JOHNSTON, P. G, WAUGH, D. J. J

“…Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more malignant phenotype. The expression of interleukin-8 (IL-8)…”
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PCAF is an HIF-1α cofactor that regulates p53 transcriptional activity in hypoxia by Xenaki, G, Ontikatze, T, Rajendran, R, Stratford, I J, Dive, C, Krstic-Demonacos, M, Demonacos, C

“…The p53 tumour suppressor is involved in several crucial cellular functions including cell-cycle arrest and apoptosis. p53 stabilization occurs under hypoxic…”
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RSU 1069, a 2-nitroimidazole containing an alkylating group: high efficiency as a radio- and chemosensitizer in vitro and in vivo by Adams, G E, Ahmed, I, Sheldon, P W, Stratford, I J

“…Electron affinity as measured by the one-electron reduction potentian, E7(1), is the major factor influencing radiosensitizing efficiency in vitro. RSU 1069…”
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Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2 by Nolan, K.A., Humphries, M.P., Bryce, R.A., Stratford, I.J.

“…Electrostatic surface representation of NQO2 with NSC660841 docked in the binding pocked. NSC660841 is identified as the most potent inhibitor of NQO2 yet…”
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Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection: results of EORTC Translational Research Fund studies by Oliver, R.J., Woodwards, R.T.M., Sloan, P., Thakker, N.S., Stratford, I.J., Airley, R.E.

“…Hypoxia in tumours of the oral cavity has not been extensively investigated with regard to clinical outcome and prognosis. The expression of the facilitative…”
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Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs by Adams, G E, Stratford, I J, Bremner, J C, Edwards, H S, Fielden, E M

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Subharmonic emission as an indicator of ultrasonically-induced biological damage by Morton, K I, Ter Haar, G R, Stratford, I J, Hill, C R

“…This paper describes work in which subharmonic emissions from ultrasonically irradiated biological samples are integrated over time, and the resultant signal…”
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435 POSTER Modulation of the activity of tumour associated carbonic anhydrases for therapeutic benefit by Glassbrook, L., Wang, R., Williams, K., Jaffar, M., Stratford, I.J.

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495 The synthesis of novel 3- and 5-piperidinyl substituted indolequinone bioreductive prodrugs: mechanism of hypoxic/reductive activity by Robinson, I., Mrema, I., Stratford, I.J., Jaffar, M.

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The influence of elevated levels of platelet-derived endothelial cell growth factor/thymidine phosphorylase on tumourigenicity, tumour growth, and oxygenation by Griffiths, L, Stratford, I J

“…Investigation of the effect of platelet-derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) on various aspects of tumour growth in a…”
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