Search Results - "Stratford, I. J."

Guidelines for the welfare and use of animals in cancer research by Workman, P, Aboagye, E O, Balkwill, F, Balmain, A, Bruder, G, Chaplin, D J, Double, J A, Everitt, J, Farningham, D A H, Glennie, M J, Kelland, L R, Robinson, V, Stratford, I J, Tozer, G M, Watson, S, Wedge, S R, Eccles, S A

“…Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and…”
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Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers by Harrington, K J, Billingham, L J, Brunner, T B, Burnet, N G, Chan, C S, Hoskin, P, Mackay, R I, Maughan, T S, Macdougall, J, McKenna, W G, Nutting, C M, Oliver, A, Plummer, R, Stratford, I J, Illidge, T

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HIF-1 and NF-κB-mediated upregulation of CXCR1 and CXCR2 expression promotes cell survival in hypoxic prostate cancer cells by MAXWELL, P. J, GALLAGHER, R, SEATON, A, WILSON, C, SCULLIN, P, PETTIGREW, J, STRATFORD, I. J, WILLIAMS, K. J, JOHNSTON, P. G, WAUGH, D. J. J

“…Hypoxic cancer cells are resistant to treatment, leading to the selection of cells with a more malignant phenotype. The expression of interleukin-8 (IL-8)…”
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ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model by WILLIAMS, K. J, TELFER, B. A, STRATFORD, I. J, WEDGE, S. R

“…The effect of ZD1839 ('Iressa'), a specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor, on the radiation response of…”
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Hypoxia-Inducible Factor-1 Modulates Gene Expression in Solid Tumors and Influences Both Angiogenesis and Tumor Growth by Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., Ratcliffe, P. J.

“…Recent studies of tissue culture cells have defined a widespread system of oxygen-regulated gene expression based on the activation of a heterodimeric…”
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Anticancer chemosensitization and radiosensitization by the novel Poly(ADP-ribose) polymerase-1 inhibitor AG14361 by CALABRESE, Christopher R, ALMASSY, Robert, LI, Jianke, MAEGLEY, Karen, NEWELL, David R, NOTARIANNI, Elena, STRATFORD, Ian J, SKALITZKY, Donald, THOMAS, Huw D, WANG, Ian-Zhen, WEBBER, Stephen E, WILLIAMS, Kaye J, BARTON, Stephanie, CURTIN, Nicola J, BATEY, Michael A, CALVERT, A. Hilary, CANAN-KOCH, Stacie, DURKACZ, Barbara W, HOSTOMSKY, Zdenek, KUMPF, Robert A, KYLE, Suzanne

“…Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates the repair of DNA strand breaks. Inhibiting PARP-1 increases the cytotoxicity of DNA-damaging chemotherapy…”
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Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells by Roberts, D L, Williams, K J, Cowen, R L, Barathova, M, Eustace, A J, Brittain-Dissont, S, Tilby, M J, Pearson, D G, Ottley, C J, Stratford, I J, Dive, C

“…Background: Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although…”
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Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection: results of EORTC Translational Research Fund studies by Oliver, R.J., Woodwards, R.T.M., Sloan, P., Thakker, N.S., Stratford, I.J., Airley, R.E.

“…Hypoxia in tumours of the oral cavity has not been extensively investigated with regard to clinical outcome and prognosis. The expression of the facilitative…”
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Platelet-derived endothelial cell growth factor thymidine phosphorylase in tumour growth and response to therapy by GRIFFITHS, L, STRATFORD, I. J

“…Angiogenesis plays an important role in the growth and metastasis of solid tumours. Platelet-derived endothelial cell growth factor (PD-ECGF) is known to be…”
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Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2 by Nolan, K.A., Humphries, M.P., Bryce, R.A., Stratford, I.J.

“…Electrostatic surface representation of NQO2 with NSC660841 docked in the binding pocked. NSC660841 is identified as the most potent inhibitor of NQO2 yet…”
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The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy by Lunt, S J, Cawthorne, C, Ali, M, Telfer, B A, Babur, M, Smigova, A, Julyan, P J, Price, P M, Stratford, I J, Bloomer, W D, Papadopoulou, M V, Williams, K J

“…Background: Metastases cause most cancer-related deaths. We investigated the use of hypoxia-selective cytotoxins as adjuvants to radiotherapy in the control of…”
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Inhibition of vascular endothelial growth factor signalling using cediranib (RECENTIN™; AZD2171) enhances radiation response and causes substantial physiological changes in lung tumour xenografts by WILLIAMS, K. J, TELFER, B. A, SHANNON, A. M, BABUR, M, STRATFORD, I. J, WEDGE, S. R

“…A number of pre-clinical studies have suggested that blocking vascular endothelial growth factor (VEGF) signalling can be beneficial in combination with…”
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Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N, a bioreductively activated anti-tumour agent by PATTERSON, L. H, MCKEOWN, S. R, RUPARELIA, K, DOUBLE, J. A, BIBBY, M. C, COLE, S, STRATFORD, I. J

“…AQ4 (1,4-Bis-[[2-(dimethylamino-N-oxide)ethyl]amino]5,8-dihydroxyanthrace ne-9, 10-dione) is a prodrug designed to be excluded from cell nuclei until…”
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The experimental development of bioreductive drugs and their role in cancer therapy by WORKMAN, P, STRATFORD, I. J

“…Bioreductive drugs undergo metabolic reduction to generate cytotoxic metabolites. This process is facilitated by bioreductive enzymes and the lower oxygen…”
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Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours by PATTERSON, A. V, WILLIAMS, K. J, STRATFORD, I. J, COWEN, R. L, JAFFAR, M, TELFER, B. A, SAUNDERS, M, AIRLEY, R, HONESS, D, VAN DER KOGEL, A. J, WOLF, C. R

“…Overwhelming clinical and experimental data demonstrate that tumour hypoxia is associated with aggressive disease and poor treatment outcome as hypoxic cells…”
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Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase by PATTERSON, A. V, ZHANG, H, MOGHADDAM, A, BICKNELL, R, TALBOT, D. C, STRATFORD, I. J, HARRIS, A. L

“…Platelet-derived endothelial cell growth factor (PD-ECGF) is identical to human thymidine phosphorylase (dThdPase). The human MCF-7 breast cancer cell line was…”
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The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo by GRIFFITHS, L, DACHS, G. U, BICKNELL, R, HARRIS, A. L, STRATFORD, I. J

“…We report that hypoxia regulates and influences the level of the angiogenic enzyme platelet-derived endothelial cell growth factor (PD-ECGF), also called…”
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Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix by GREEN, M. M. L, HUTCHISON, G. J, VALENTINE, H. R, FITZMAURICE, R. J, DAVIDSON, S. E, HUNTER, R. D, DIVE, C, WEST, C. M. L, STRATFORD, I. J

“…The Bcl-2 family of apoptotic regulators is thought to play an essential role in cancer development and influence the sensitivity of tumour cells to…”
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Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenografts by Airley, R E, Phillips, R M, Evans, A E, Double, J, Burger, A M, Feibig, H H, West, C M L, Stratford, I J

“…Tumour hypoxia confers poor prognosis in a wide range of solid tumours, due to an increased malignancy, increased likelihood of metastasis and treatment…”
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No relationship between thymidine phosphorylase (TP, PD-ECGF) expression and hypoxia in carcinoma of the cervix by KABUUBI, P, LONCASTER, J. A, DAVIDSON, S. E, HUNTER, R. D, KOBYLECKI, C, STRATFORD, I. J, WEST, C. M. L

“…The expression of hypoxia-regulated genes promotes an aggressive tumour phenotype and is associated with an adverse cancer treatment outcome. Thymidine…”
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