Ofloxacin intravenous. Compatibility with other antibacterial agents

The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate f...

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Bibliographic Details
Published in:	Pharmaceutisch weekblad. Scientific edition Vol. 13; no. 5; p. 207
Main Authors:	Janknegt, R, Stratermans, T, Cilissen, J, Lohman, J J, Hooymans, P M
Format:	Journal Article
Language:	English
Published:	Netherlands 18-10-1991
Subjects:	Anti-Bacterial Agents - chemistry Chemical Precipitation Humans Injections, Intravenous Ofloxacin - administration & dosage Ofloxacin - analysis Ofloxacin - chemistry
Online Access:	Get more information
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Summary:	The physical and chemical compatibility of ofloxacin (infusion solution 100 ml = 200 mg) with amoxicillin, amoxicillin + clavulanic acid, flucloxacillin, tobramycin, gentamicin, clindamycin, vancomycin, ceftazidime and piperacillin was investigated. Upon admixture with flucloxacillin a precipitate formed between 7 and 24 hours. No other physical or chemical incompatibilities were observed with any of the other combinations. Ofloxacin may be safely combined with the tested antimicrobial drugs, except for flucloxacillin.
ISSN:	0167-6555
DOI:	10.1007/BF01988876