Anaesthesia protocol evaluation of the videolaryngoscopy with the McGrath MAC and direct laryngoscopy for tracheal intubation in 1000 patients undergoing rapid sequence induction: the randomised multicentre LARA trial study protocol

Rapid sequence induction of anaesthesia is indicated in patients with an increased risk of pulmonary aspiration. The main objective of the technique is to reduce the critical time period between loss of airway protective reflexes and rapid inflation of the cuff of the endotracheal tube to minimise t...

Full description

Saved in:

Bibliographic Details
Published in:	BMJ open Vol. 11; no. 10; p. e052977
Main Authors:	Kriege, Marc, Lang, Philipp, Lang, Christoph, Pirlich, Nina, Griemert, Eva-Verena, Heid, Florian, Wittenmeier, Eva, Schmidtmann, Irene, Schmidbauer, W, Jänig, Christoph, Jungbecker, Johannes, Kunitz, Oliver, Strate, Maximilian, Schmutz, Axel
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group LTD 06-10-2021 BMJ Publishing Group
Series:	Protocol
Subjects:	Airway management Anaesthesia Anesthesia COVID-19 General anesthesia Humans Intubation Intubation, Intratracheal - adverse effects Laryngoscopes Laryngoscopy Multicenter Studies as Topic Pandemics Patients Pulmonary aspiration Randomized Controlled Trials as Topic Rapid Sequence Induction and Intubation SARS-CoV-2 Success Surgery adult anaesthesia adult intensive & critical care surgery
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Rapid sequence induction of anaesthesia is indicated in patients with an increased risk of pulmonary aspiration. The main objective of the technique is to reduce the critical time period between loss of airway protective reflexes and rapid inflation of the cuff of the endotracheal tube to minimise the chance of aspiration of gastric contents. The COVID-19 pandemic has reinforced the importance of first-pass intubation success to ensure patient and healthcare worker safety. The aim of this study is to compare the first-pass intubation success rate (FPS) using the videolaryngoscopy compared with conventional direct laryngoscopy in surgical patients with a high risk of pulmonary aspiration. The LARA trial is a multicentre, patient-blinded, randomised controlled trial. Consecutive patients requiring tracheal intubation are randomly allocated to either the McGrath MAC videolaryngoscope or direct laryngoscopy using the Macintosh laryngoscope. The expected rate of FPS is 92% in the McGrath group and 82% in the Macintosh group. Each group must include a total of 500 patients to achieve 90% power for detecting a difference at the 5% significance level. Successful intubation with the FPS is the primary endpoint. The secondary endpoints are the time to intubation, the number of intubation attempts, the necessity of airway management alternatives, the visualisation of the glottis using the Cormack and Lehane Score and the Percentage Of Glottic Opening Score and definite adverse events. The project is approved by the local ethics committee of the Medical Association of the Rhineland Palatine state (registration number: 2020-15502) and medical ethics committee of the University of Freiburg (registration number: 21-1303). The results of this study will be made available in form of manuscripts for publication and presentations at national and international meetings. NCT04794764.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2021-052977