Search Results - "Strasser, Andreas"

Emerging connectivity of programmed cell death pathways and its physiological implications by Bedoui, Sammy, Herold, Marco J., Strasser, Andreas

“…The removal of functionally dispensable, infected or potentially neoplastic cells is driven by programmed cell death (PCD) pathways, highlighting their…”
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Molecular mechanisms of cell death in neurological diseases by Moujalled, Diane, Strasser, Andreas, Liddell, Jeffrey R.

“…Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to…”
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The role of BH3-only proteins in the immune system by Strasser, Andreas

“…Programmed cell death--also known as apoptosis--has a crucial role in the immune system of mammals and other animals. It removes useless cells and potentially…”
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In operando detection of Lithium plating via electrochemical impedance spectroscopy for automotive batteries by Straßer, Andreas, Adam, Alexander, Li, Jiahao

“…Reducing the charging time is one of the main goals towards increasing the acceptance of electric vehicles. One of the limits of fast charging lithium-ion…”
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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy by Czabotar, Peter E., Lessene, Guillaume, Strasser, Andreas, Adams, Jerry M.

“…Key Points The BCL-2 protein family principally determines whether a cell commits to apoptosis and hence has crucial roles in development, tissue homeostasis…”
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Viewing BCL2 and cell death control from an evolutionary perspective by Strasser, Andreas, Vaux, David L

“…The last 30 years of studying BCL2 have brought cell death research into the molecular era, and revealed its relevance to human pathophysiology. Most, if not…”
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Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases by Strasser, Andreas, Cory, Suzanne, Adams, Jerry M

“…Apoptosis, the major form of programmed cell death in metazoan organisms, plays critical roles in normal development, tissue homeostasis and immunity, and its…”
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines by Merino, Delphine, Kelly, Gemma L., Lessene, Guillaume, Wei, Andrew H., Roberts, Andrew W., Strasser, Andreas

“…Defects in apoptotic cell death can promote cancer and impair responses of malignant cells to anti-cancer therapy. Pro-survival BCL-2 proteins prevent…”
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The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs by Diepstraten, Sarah T., Anderson, Mary Ann, Czabotar, Peter E., Lessene, Guillaume, Strasser, Andreas, Kelly, Gemma L.

“…Apoptosis is a form of programmed cell death that is regulated by the balance between prosurvival and proapoptotic BCL-2 protein family members. Evasion of…”
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The Many Roles of FAS Receptor Signaling in the Immune System by Strasser, Andreas, Jost, Philipp J., Nagata, Shigekazu

“…FAS belongs to the subgroup of the tumor necrosis factor receptor (TNF-R) family that contains an intracellular “death domain” and triggers apoptosis. Its…”
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The essentials of developmental apoptosis [version 1; peer review: awaiting peer review] by Voss, Anne K, Strasser, Andreas

“…Apoptotic cells are commonly observed in a broad range of tissues during mammalian embryonic and fetal development. Specific requirements and functions of…”
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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models by Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Maragno, Ana Leticia, Le Toumelin-Braizat, Gaëtane, Chanrion, Maïa, Kelly, Gemma L., Gong, Jia-Nan, Moujalled, Donia M., Bruno, Alain, Csekei, Márton, Paczal, Attila, Szabo, Zoltán B., Sipos, Szabolcs, Radics, Gábor, Proszenyak, Agnes, Balint, Balázs, Ondi, Levente, Blasko, Gábor, Robertson, Alan, Surgenor, Allan, Dokurno, Pawel, Chen, Ijen, Matassova, Natalia, Smith, Julia, Pedder, Christopher, Graham, Christopher, Studeny, Aurélie, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Gravé, Fabienne, Segal, David, Riffkin, Chris D., Pomilio, Giovanna, Galbraith, Laura C. A., Aubrey, Brandon J., Brennan, Margs S., Herold, Marco J., Chang, Catherine, Guasconi, Ghislaine, Cauquil, Nicolas, Melchiore, Fabien, Guigal-Stephan, Nolwen, Lockhart, Brian, Colland, Frédéric, Hickman, John A., Roberts, Andrew W., Huang, David C. S., Wei, Andrew H., Strasser, Andreas, Lessene, Guillaume, Geneste, Olivier

“…Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is…”
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Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK by Ke, Francine F.S., Vanyai, Hannah K., Cowan, Angus D., Delbridge, Alex R.D., Whitehead, Lachlan, Grabow, Stephanie, Czabotar, Peter E., Voss, Anne K., Strasser, Andreas

“…Intrinsic apoptosis, reliant on BAX and BAK, has been postulated to be fundamental for morphogenesis, but its precise contribution to this process has not been…”
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Is tumor growth sustained by rare cancer stem cells or dominant clones? by Adams, Jerry M, Strasser, Andreas

“…A key issue for cancer biology and therapy is whether the relentless growth of a tumor is driven by a substantial proportion of its cells or exclusively by a…”
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The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis by Alvarez-Diaz, Silvia, Dillon, Christopher P., Lalaoui, Najoua, Tanzer, Maria C., Rodriguez, Diego A., Lin, Ann, Lebois, Marion, Hakem, Razq, Josefsson, Emma C., O’Reilly, Lorraine A., Silke, John, Alexander, Warren S., Green, Douglas R., Strasser, Andreas

“…The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL…”
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An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo by Aubrey, Brandon J., Kelly, Gemma L., Kueh, Andrew J., Brennan, Margs S., O’Connor, Liam, Milla, Liz, Wilcox, Stephen, Tai, Lin, Strasser, Andreas, Herold, Marco J.

“…The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene…”
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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Macrophage and neutrophil death programs differentially confer resistance to tuberculosis by Stutz, Michael Dominic, Allison, Cody Charles, Ojaimi, Samar, Preston, Simon Peter, Doerflinger, Marcel, Arandjelovic, Philip, Whitehead, Lachlan, Bader, Stefanie M., Batey, Daniel, Asselin-Labat, Marie-Liesse, Herold, Marco J., Strasser, Andreas, West, Nicholas P., Pellegrini, Marc

“…Apoptosis can potently defend against intracellular pathogens by directly killing microbes and eliminating their replicative niche. However, the reported…”
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Mcl-1 is essential for the survival of plasma cells by Peperzak, Victor, Vikström, Ingela, Walker, Jennifer, Glaser, Stefan P, LePage, Melanie, Coquery, Christine M, Erickson, Loren D, Fairfax, Kirsten, Mackay, Fabienne, Strasser, Andreas, Nutt, Stephen L, Tarlinton, David M

“…Tarlinton and colleagues show that the antiapoptotic protein Mcl1 is essential for plasma cell survival and is induced by BCMA signaling in bone marrow, but…”
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The BCL‐2 family member BID plays a role during embryonic development in addition to its BH3‐only protein function by acting in parallel to BAX, BAK and BOK by Ke, Francine S, Holloway, Steven, Uren, Rachel T, Wong, Agnes W, Little, Melissa H, Kluck, Ruth M, Voss, Anne K, Strasser, Andreas

“…The intrinsic apoptosis pathway, regulated by the BCL‐2 protein family, is essential for embryonic development. Using mice lacking all known apoptosis…”
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