Biocomposites for Oncological Treatment Based on Ultrafine Polyhydroxybutyrate Fibers Obtained by Electrospinning

Biocomposites for Oncological Treatment Based on Ultrafine Polyhydroxybutyrate Fibers Obtained by Electrospinning

This work shows the effectiveness of using biocomposites based on nonwoven fibrous materials for the treatment of cancer. Polyhydroxybutyrate nonwoven materials were obtained by electrospinning. Hydroxyapatite was introduced into the interior of the fibers, and a porous film was created on the surfa...

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Bibliographic Details
Published in:Polymer science. Series D, Glues and sealing materials Vol. 12; no. 2; pp. 218 - 222
Main Authors: Ol’khov, A. A., Gorshenev, V. N., Muravlev, I. A., Strashnova, M. G., Iordanskii, A. L.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 2019
Springer Nature B.V
Subjects:
Biomedical materials
Chemistry
Chemistry and Materials Science
Composite materials
Electrospinning
Hydroxyapatite
Polyhydroxybutyrate
Polymer Sciences
Ultrafines
hydroxyapatite
electrospinning
release
polyhydroxybutyrate
porous films
endoxan
cytotoxicity
biocomposites
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Summary:This work shows the effectiveness of using biocomposites based on nonwoven fibrous materials for the treatment of cancer. Polyhydroxybutyrate nonwoven materials were obtained by electrospinning. Hydroxyapatite was introduced into the interior of the fibers, and a porous film was created on the surface of the nonwoven material. Both the types of matrices included the anticancer drug endoxan. It was shown that the fiber-based matrices have a low endoxan release rate, while the film-coated matrices are characterized by a high rate of endoxan release.
ISSN:1995-4212
1995-4220
DOI:10.1134/S1995421219020175