Group B Streptococcal Disease in Nonpregnant Adults

Group B Streptococcal Disease in Nonpregnant Adults

Group B streptococcal (GBS) disease in nonpregnant adults is increasing, particularly in elderly persons and those with significant underlying diseases. Diabetes, neurological impairment, and cirrhosis increase risk for invasive GBS disease. Skin, soft-tissue, and osteoarticular infections, pneumoni...

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Bibliographic Details
Published in:Clinical infectious diseases Vol. 33; no. 4; pp. 556 - 561
Main Authors: Farley, Monica M., Strasbaugh, Larry J.
Format: Journal Article
Language:English
Published: Chicago, IL The University of Chicago Press 15-08-2001
University of Chicago Press
Subjects:
Adolescent
Adult
Aged
Bacterial diseases
Biological and medical sciences
Diabetes
Diabetes mellitus
Disease risk
Emerging diseases
Emerging Infections
Endocarditis
Epidemiology
Human bacterial diseases
Humans
Infections
Infectious diseases
Medical sciences
Middle Aged
Neonatal diseases
Nervous system diseases
Preventive medicine
Staphylococcal infections, streptococcal infections, pneumococcal infections
Streptococcal Infections - epidemiology
Streptococcal Infections - microbiology
Streptococcal Infections - physiopathology
Streptococcal Infections - prevention & control
Streptococcus agalactiae - classification
Human
Clinical form
Epidemiology
Incidence
Infection
Streptococcaceae
Chemotherapy
Treatment
Streptococcal infection
Streptococcus B
Bacteriosis
Bacteria
Micrococcales
Adult
Diagnosis
Localization
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Description
Summary:Group B streptococcal (GBS) disease in nonpregnant adults is increasing, particularly in elderly persons and those with significant underlying diseases. Diabetes, neurological impairment, and cirrhosis increase risk for invasive GBS disease. Skin, soft-tissue, and osteoarticular infections, pneumonia, and urosepsis are common presentations. Meningitis and endocarditis are less common but associated with serious morbidity and mortality. Disease is frequently nosocomial and may be related to the placement of an iv catheter. Recurrent infection occurs in 4.3% of survivors. Capsular serotypes Ia, III, and V account for the majority of disease in nonpregnant adults. Although group B streptococci are susceptible to penicillin, minimum inhibitory concentrations are 4-fold to 8-fold higher than for group A streptococci. Resistance to erythromycin and clindamycin is increasing. The role of antibodies in protection against GBS disease in nonpregnant adults is unresolved. However, the immunogenicity of GBS vaccines being developed for prevention of neonatal disease should be assessed for adults who are at risk.
Bibliography:ark:/67375/HXZ-ZPZSQB1W-1
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ISSN:1058-4838
1537-6591
DOI:10.1086/322696