Search Results - "Strange, W"

Resolving polymorphs and radiation‐driven effects in microcrystals using fixed‐target serial synchrotron crystallography by Ebrahim, Ali, Appleby, Martin V., Axford, Danny, Beale, John, Moreno-Chicano, Tadeo, Sherrell, Darren A., Strange, Richard W., Hough, Michael A., Owen, Robin L.

“…The ability to determine high‐quality, artefact‐free structures is a challenge in micro‐crystallography, and the rapid onset of radiation damage and…”
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Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 by Capper, Michael J, O'Neill, Paul M, Fisher, Nicholas, Strange, Richard W, Moss, Darren, Ward, Stephen A, Berry, Neil G, Lawrenson, Alexandre S, Hasnain, S Samar, Biagini, Giancarlo A, Antonyuk, Svetlana V

“…Cytochrome bc1 is a proven drug target in the prevention and treatment of malaria. The rise in drug-resistant strains of Plasmodium falciparum, the organism…”
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Tannerella forsythia Tfo belongs to Porphyromonas gingivalis HmuY-like family of proteins but differs in heme-binding properties by Bielecki, Marcin, Antonyuk, Svetlana, Strange, Richard W, Smalley, John W, Mackiewicz, Paweł, Śmiga, Michał, Stępień, Paulina, Olczak, Mariusz, Olczak, Teresa

“…is considered the principal etiologic agent and keystone pathogen of chronic periodontitis. As an auxotrophic bacterium, it must acquire heme to survive and…”
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Antiproliferative Effects of Phosphodiesterase Type 5 Inhibition in Human Pulmonary Artery Cells by Wharton, John, Strange, Julian W, Moller, Gigi M. O, Growcott, Ellena J, Ren, Xiaohui, Franklyn, Angela P, Phillips, Stephen C, Wilkins, Martin R

“…Phosphodiesterase Type 5 (PDE5) inhibition represents a novel strategy for the treatment of pulmonary hypertension. Our aim was to establish the distribution…”
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Phosphodiesterase type 5 as a target for the treatment of hypoxia-induced pulmonary hypertension by SEBKHI, A, STRANGE, Julian W, PHILLIPS, Steven C, WHARTON, John, WILKINS, Martin R

“…Phosphodiesterase type 5 (PDE5) is a novel therapeutic target for the treatment of pulmonary hypertension. This study examined the distribution of PDE5 in…”
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Distinguishing Nitro vs Nitrito Coordination in Cytochrome c′ Using Vibrational Spectroscopy and Density Functional Theory by Nilsson, Zach N, Mandella, Brian L, Sen, Kakali, Kekilli, Demet, Hough, Michael A, Moënne-Loccoz, Pierre, Strange, Richard W, Andrew, Colin R

“…Nitrite coordination to heme cofactors is a key step in the anaerobic production of the signaling molecule nitric oxide (NO). An ambidentate ligand, nitrite…”
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Dose-resolved serial synchrotron and XFEL structures of radiation-sensitive metalloproteins by Ebrahim, Ali, Moreno-Chicano, Tadeo, Appleby, Martin V, Chaplin, Amanda K, Beale, John H, Sherrell, Darren A, Duyvesteyn, Helen M E, Owada, Shigeki, Tono, Kensuke, Sugimoto, Hiroshi, Strange, Richard W, Worrall, Jonathan A R, Axford, Danny, Owen, Robin L, Hough, Michael A

“…An approach is demonstrated to obtain, in a sample- and time-efficient manner, multiple dose-resolved crystal structures from room-temperature protein…”
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Nature of the copper-nitrosyl intermediates of copper nitrite reductases during catalysis by Hough, Michael A, Conradie, Jeanet, Strange, Richard W, Antonyuk, Svetlana V, Eady, Robert R, Ghosh, Abhik, Hasnain, S. Samar

“…The design and synthesis of copper complexes that can reduce nitrite to NO has attracted considerable interest. They have been guided by the structural…”
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Atomic Resolution Structures of Resting-State, Substrate- and Product-Complexed Cu-Nitrite Reductase Provide Insight into Catalytic Mechanism by Antonyuk, Svetlana V, Strange, Richard W, Sawers, Gary, Eady, Robert R, Hasnain, S Samar

“…Copper-containing nitrite reductases catalyze the reduction of nitrite to nitric oxide (NO), a key step in denitrification that results in the loss of…”
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Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases by Bellini, Dom, Horrell, Sam, Hutchin, Andrew, Phippen, Curtis W., Strange, Richard W., Cai, Yuming, Wagner, Armin, Webb, Jeremy S., Tews, Ivo, Walsh, Martin A.

“…The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of…”
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Variable Metallation of Human Superoxide Dismutase: Atomic Resolution Crystal Structures of Cu–Zn, Zn–Zn and As-isolated Wild-type Enzymes by Strange, Richard W., Antonyuk, Svetlana V., Hough, Michael A., Doucette, Peter A., Valentine, Joan Selverstone, Hasnain, S. Samar

“…Human Cu–Zn superoxide dismutase (SOD1) protects cells from the effects of oxidative stress. Mutations in SOD1 are linked to the familial form of amyotrophic…”
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Serial crystallography captures enzyme catalysis in copper nitrite reductase at atomic resolution from one crystal by Horrell, Sam, Antonyuk, Svetlana V, Eady, Robert R, Hasnain, S Samar, Hough, Michael A, Strange, Richard W

“…Relating individual protein crystal structures to an enzyme mechanism remains a major and challenging goal for structural biology. Serial crystallography using…”
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A QM/MM Study of Nitrite Binding Modes in a Three-Domain Heme-Cu Nitrite Reductase by Sen, Kakali, Hough, Michael A, Strange, Richard W, Yong, Chin W, Keal, Thomas W

“…Copper-containing nitrite reductases (CuNiRs) play a key role in the global nitrogen cycle by reducing nitrite (NO₂ ) to nitric oxide, a reaction that involves…”
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High-throughput structures of protein-ligand complexes at room temperature using serial femtosecond crystallography by Moreno-Chicano, Tadeo, Ebrahim, Ali, Axford, Danny, Appleby, Martin V, Beale, John H, Chaplin, Amanda K, Duyvesteyn, Helen M E, Ghiladi, Reza A, Owada, Shigeki, Sherrell, Darren A, Strange, Richard W, Sugimoto, Hiroshi, Tono, Kensuke, Worrall, Jonathan A R, Owen, Robin L, Hough, Michael A

“…High-throughput X-ray crystal structures of protein-ligand complexes are critical to pharmaceutical drug development. However, cryocooling of crystals and…”
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Coronary Stenosis and Cardiogenic Shock Secondary to Aortitis Following Aortic Root Support Procedure by Carpenter, Alexander, Connaire, Stephanie, Chandra Mohan, Nitin, Curtis, Stephanie L., Stoica, Serban C., Caputo, Massimo, Strange, Julian W.

“…A woman with recent personalized external aortic root support implant presented in cardiogenic shock with bilateral coronary ostial occlusion and aortic…”
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The Structure of Holo and Metal-deficient Wild-type Human Cu, Zn Superoxide Dismutase and its Relevance to Familial Amyotrophic Lateral Sclerosis by Strange, Richard W., Antonyuk, Svetlana, Hough, Michael A., Doucette, Peter A., Rodriguez, Jorge A., Hart, P.John, Hayward, Lawrence J., Valentine, Joan S., Hasnain, S.Samar

“…Cu, Zn superoxide dismutase (SOD1) forms a crucial component of the cellular defence against oxidative stress. Zn-deficient wild-type and mutant human SOD1…”
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Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants by Hough, Michael A., Grossmann, J. Günter, Antonyuk, Svetlana V., Strange, Richard W., Doucette, Peter A., Rodriguez, Jorge A., Whitson, Lisa J., Hart, P. John, Hayward, Lawrence J., Valentine, Joan Selverstone, Hasnain, S. Samar, Petsko, Gregory A.

“…More than 90 point mutations in human CuZn superoxide dismutase lead to the development of familial amyotrophic lateral sclerosis, known also as motor neuron…”
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Crystal structure of human prion protein bound to a therapeutic antibody by Antonyuk, S.V, Trevitt, C.R, Strange, R.W, Jackson, G.S, Sangar, D, Batchelor, M, Cooper, S, Fraser, C, Jones, S, Georgiou, T, Khalili-Shirazi, A, Clarke, A.R, Hasnain, S.S, Collinge, J

“…Prion infection is characterized by the conversion of host cellular prion protein (PrPC) into disease-related conformers (PrPSc) and can be arrested in vivo by…”
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Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature by Moreno-Chicano, Tadeo, Carey, Leiah M, Axford, Danny, Beale, John H, Doak, R Bruce, Duyvesteyn, Helen M E, Ebrahim, Ali, Henning, Robert W, Monteiro, Diana C F, Myles, Dean A, Owada, Shigeki, Sherrell, Darren A, Straw, Megan L, Šrajer, Vukica, Sugimoto, Hiroshi, Tono, Kensuke, Tosha, Takehiko, Tews, Ivo, Trebbin, Martin, Strange, Richard W, Weiss, Kevin L, Worrall, Jonathan A R, Meilleur, Flora, Owen, Robin L, Ghiladi, Reza A, Hough, Michael A

“…Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in…”
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A Study of Platelet Inhibition, Using a 'Point of Care' Platelet Function Test, following Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction [PINPOINT-PPCI] by Johnson, Thomas W, Mumford, Andrew D, Scott, Lauren J, Mundell, Stuart, Butler, Mark, Strange, Julian W, Rogers, Chris A, Reeves, Barnaby C, Baumbach, Andreas

“…Rapid coronary recanalization following ST-elevation myocardial infarction (STEMI) requires effective anti-platelet and anti-thrombotic therapies. This study…”
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