Search Results - "Strand, Douglas"
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Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor
Published in Molecular cell (15-09-2016)“…Prostate inflammation has been suggested as an etiology for benign prostatic hyperplasia (BPH). We show that decreased expression of the androgen receptor (AR)…”
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2
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
Published in Cell stem cell (01-04-2021)“…Adipose precursor cells (APCs) exhibit regional variation in response to obesity, for unclear reasons. Here, we reveal that HIFα-induced PDGFRβ signaling…”
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3
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra
Published in Cell reports (Cambridge) (18-12-2018)“…A comprehensive cellular anatomy of normal human prostate is essential for solving the cellular origins of benign prostatic hyperplasia and prostate cancer…”
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4
Cancer associated fibroblasts in cancer pathogenesis
Published in Seminars in cell & developmental biology (01-02-2010)“…In the past century, gradual but sustained advances in our understanding of the molecular mechanisms involved in the growth and invasive properties of cancer…”
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5
Identification and characterization of cellular heterogeneity within the developing renal interstitium
Published in Development (Cambridge) (14-08-2020)“…Kidney formation requires the coordinated growth of multiple cell types including the collecting ducts, nephrons, vasculature and interstitium. There is a…”
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6
Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
Published in eLife (28-09-2018)“…White adipose tissue (WAT) remodeling is dictated by coordinated interactions between adipocytes and resident stromal-vascular cells; however, the functional…”
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7
Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories
Published in Cancer cell (10-12-2018)“…Identifying the earliest somatic changes in prostate cancer can give important insights into tumor evolution and aids in stratifying high- from low-risk…”
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8
Single‐cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions
Published in The Journal of pathology (01-10-2021)“…Stromal–epithelial interactions are critical to the morphogenesis, differentiation, and homeostasis of the prostate, but the molecular identity and anatomy of…”
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9
Design and validation of a high-speed hyperspectral laparoscopic imaging system
Published in Journal of biomedical optics (01-09-2024)“…Minimally invasive surgery (MIS) has shown vast improvement over open surgery by reducing post-operative stays, intraoperative blood loss, and infection rates…”
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10
A multi-omic investigation of male lower urinary tract symptoms: Potential role for JC virus
Published in PloS one (25-02-2021)“…Male lower urinary tract symptoms (LUTS) comprise a common syndrome of aging that negatively impacts quality of life. The etiology of LUTS is multifactorial,…”
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11
Progenitors in prostate development and disease
Published in Developmental biology (01-05-2021)“…The prostate develops by epithelial budding and branching processes that occur during fetal and postnatal stages. The adult prostate demonstrates remarkable…”
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12
5‐Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
Published in The Journal of pathology (01-04-2022)“…Benign prostatic hyperplasia (BPH) is a progressive expansion of peri‐urethral prostate tissue common in aging men. Patients with enlarged prostates are…”
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Serum MicroRNA-371a-3p Levels Predict Viable Germ Cell Tumor in Chemotherapy-naïve Patients Undergoing Retroperitoneal Lymph Node Dissection
Published in European urology (01-02-2020)Get full text
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14
Urethral luminal epithelia are castration‐insensitive cells of the proximal prostate
Published in The Prostate (01-08-2020)“…Background Castration‐insensitive epithelial progenitors capable of regenerating the prostate have been proposed to be concentrated in the proximal region…”
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15
A Review of Prostate Organogenesis and a Role for iPSC-Derived Prostate Organoids to Study Prostate Development and Disease
Published in International journal of molecular sciences (03-12-2021)“…The prostate is vulnerable to two major age-associated diseases, cancer and benign enlargement, which account for significant morbidity and mortality for men…”
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16
Targeting phenotypic heterogeneity in benign prostatic hyperplasia
Published in Differentiation (London) (01-07-2017)“…Benign prostatic hyperplasia and associated lower urinary tract symptoms remain difficult to treat medically, resulting in hundreds of thousands of surgeries…”
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17
Single-cell and spatial transcriptomics identify COL6A3 as a prognostic biomarker in undifferentiated pleomorphic sarcoma
Published in Molecular cancer (15-11-2024)“…Undifferentiated pleomorphic sarcoma (UPS) and related tumors are the most common type of soft tissue sarcoma. However, this spectrum of tumors has different…”
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Real-World Application of Pre-Orchiectomy miR-371a-3p Test in Testicular Germ Cell Tumor Management
Published in The Journal of urology (01-01-2021)“…Current serum tumor markers for testicular germ cell tumor are limited by low sensitivity. Growing evidence supports the use of circulating miR-371a-3p as a…”
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19
The many ways to make a luminal cell and a prostate cancer cell
Published in Endocrine-related cancer (01-12-2015)“…Research in the area of stem/progenitor cells has led to the identification of multiple stem-like cell populations implicated in prostate homeostasis and…”
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20
Refining the serum miR-371a-3p test for viable germ cell tumor detection
Published in Scientific reports (29-06-2023)“…Circulating miR-371a-3p has excellent performance in the detection of viable (non-teratoma) germ cell tumor (GCT) pre-orchiectomy; however, its ability to…”
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