Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients

Possible synergistic effect of apoE and LRP1 genotypes on metabolic syndrome development in Serbian patients

The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a str...

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Bibliographic Details
Published in:Molecular biology reports Vol. 46; no. 6; pp. 6345 - 6351
Main Authors: Vučinić, N., Stankov, K., Đan, M., Barjaktarović, I., Stokić, E., Strajnić, L. J., Obreht, D., Đan, I.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-12-2019
Springer Nature B.V
Subjects:
Adult
Animal Anatomy
Animal Biochemistry
Apolipoprotein E
Apolipoproteins E - genetics
Biomedical and Life Sciences
Case-Control Studies
Coronary artery disease
Female
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Heart diseases
Histology
Humans
Life Sciences
Low Density Lipoprotein Receptor-Related Protein-1 - genetics
Male
Metabolic syndrome
Metabolic Syndrome - genetics
Middle Aged
Morphology
Myocardial infarction
Original Article
Polymerase chain reaction
Polymorphism, Restriction Fragment Length
Receptor density
Restriction fragment length polymorphism
Serbia
Young Adult
Serbia
Metabolic syndrome
gene variants
LRP1 gene variants
apoE gene variants
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Summary:The modern way of life contributes to the higher frequency of a complex state medically called metabolic syndrome (MetS), which is an inevitable consequence of several most common diseases of modern civilization. Patients with MetS have three times higher risk of experiencing a heart attack or a stroke and twice higher possibility to die from them. Serbia holds the infamous third place in Europe in mortality from heart disease, just behind Russia and Ukraine. The study explores the correlation of every combination of genotypes of apoE (apolipoprotein E) and LRP1 (low density receptor- related protein 1) genes with presence of MetS, and the connection with each anthropometric and biochemical parameter in both tested groups. Study demonstrates the impact of genotype combinations on the emergence and development of the MetS in Serbia. 63 patients and 30 controls were included in the study, aged from 19 to 65. Each person genotype was determined by the polymerase chain reaction–restriction fragment length polymorphism (PCR–RFLP) profile. Odds ratio (OR) values showed that the presence of apoE e3e4/ LRP1 CC genotype combination of genotypes in patients multiplies the chance (7.6 times) for the occurrence of the MetS in comparison to the presence of other genotype combinations. Determining the genetic basis of MetS is one of the necessary steps in the prevention of disease, saving the cost of treatment, and in the design of targeted therapies.
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ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-019-05076-z