Search Results - "Strait, Richard"

Human IgE-independent systemic anaphylaxis by Finkelman, Fred D., MD, Khodoun, Marat V., PhD, Strait, Richard, MD

“…Anaphylaxis is a rapidly developing, life-threatening, generalized or systemic allergic reaction that is classically elicited by antigen crosslinking of…”
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The importance of mast cell histamine secretion in IgG-mediated systemic anaphylaxis by Khodoun, Marat V., Strait, Richard T., Hall, Ashley, Stolfi, Adrienne, Finkelman, Fred D.

“…[Display omitted] IgG can mediate murine and human systemic anaphylaxis (SA). The roles of mast cells (MCs) and histamine in IgG-mediated anaphylaxis are…”
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Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1 by Karsten, Christian M, Pandey, Manoj K, Figge, Julia, Kilchenstein, Regina, Taylor, Philip R, Rosas, Marcela, McDonald, Jacqueline U, Orr, Selinda J, Berger, Markus, Petzold, Dominique, Blanchard, Veroniqué, Winkler, André, Hess, Constanze, Reid, Delyth M, Majoul, Irina V, Strait, Richard T, Harris, Nathaniel L, Köhl, Gabriele, Wex, Eva, Ludwig, Ralf, Zillikens, Detlef, Nimmerjahn, Falk, Finkelman, Fred D, Brown, Gordon D, Ehlers, Marc, Köhl, Jörg

“…Complement components activate and recruit immune cells, promoting host defense and inflammatory disease. Jörg Köhl and his colleagues demonstrate that IgG1…”
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Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response by Xiao, Chang, MD, PhD, Biagini Myers, Jocelyn M., PhD, Ji, Hong, PhD, Metz, Kelly, MD, Martin, Lisa J., PhD, Lindsey, Mark, BS, He, Hua, MS, Powers, Racheal, BS, Ulm, Ashley, BS, Ruff, Brandy, Ericksen, Mark B., BS, Somineni, Hari K., MS, Simmons, Jeffrey, MD, Strait, Richard T., MD, Kercsmar, Carolyn M., MD, Khurana Hershey, Gurjit K., MD, PhD

“…Background There is considerable heterogeneity in asthma treatment response. Objective We sought to identify biomarkers of corticosteroid treatment response in…”
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Head-to-head comparison of protocol modifications for the generation of collagen-induced arthritis in a specific-pathogen free facility using DBA/1 mice by Thornton, Sherry, Strait, Richard T

“…Collagen-induced arthritis (CIA) is a widely used mouse model for studying inflammatory arthritis (IA). However, CIA induction protocols differ between…”
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Identification of markers that distinguish IgE- from IgG-mediated anaphylaxis by Khodoun, Marat V, Strait, Richard, Armstrong, Laura, Yanase, Noriko, Finkelman, Fred D

“…IgG-mediated anaphylaxis occurs in mice and may contribute to human reactions to infused drugs. To distinguish IgE- from putative IgG-mediated human…”
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MHC class I-specific antibody binding to nonhematopoietic cells drives complement activation to induce transfusion-related acute lung injury in mice by Strait, Richard T, Hicks, Wyenona, Barasa, Nathaniel, Mahler, Ashley, Khodoun, Marat, Köhl, Jörg, Stringer, Keith, Witte, David, Van Rooijen, Nico, Susskind, Brian M, Finkelman, Fred D

“…Transfusion-related acute lung injury (TRALI), a form of noncardiogenic pulmonary edema that develops during or within 6 h after a blood transfusion, is the…”
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Immunoglobulin Glycosylation Effects in Allergy and Immunity by Epp, Alexandra, Sullivan, Kathryn C., Herr, Andrew B., Strait, Richard T.

“…Purpose of Review The aim of this review will be to familiarize the reader with the general area of antibody (Ab) glycosylation and to summarize the known…”
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IgG1 protects against renal disease in a mouse model of cryoglobulinaemia by Strait, Richard T., Posgai, Monica T., Mahler, Ashley, Barasa, Nathaniel, Jacob, Chaim O., Köhl, Jörg, Ehlers, Marc, Stringer, Keith, Shanmukhappa, Shiva Kumar, Witte, David, Hossain, Md Monir, Khodoun, Marat, Herr, Andrew B., Finkelman, Fred D.

“…Here, the predominant murine immunoglobulin G subclass, IgG1, which is a poor activator of effector mechanisms, is shown to have a regulatory function,…”
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Rapid desensitization of mice with anti-FcγRIIb/FcγRIII mAb safely prevents IgG-mediated anaphylaxis by Khodoun, Marat V., PhD, Kucuk, Zeynep Yesim, MD, Strait, Richard T., MD, Krishnamurthy, Durga, PhD, Janek, Kevin, BA, Clay, Corey D., MD, PhD, Morris, Suzanne C., PhD, Finkelman, Fred D., MD

“…Background Stimulatory IgG receptors (FcγRs) on bone marrow-derived cells contribute to the pathogenesis of several autoimmune and inflammatory disorders…”
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Anti-FcγRIIB mAb suppresses murine IgG-dependent anaphylaxis by Fc domain targeting of FcγRIII by Clay, Corey D., Strait, Richard T., Mahler, Ashley, Khodoun, Marat V., Finkelman, Fred D.

“…The inhibitory receptor FcγRIIB is expressed on human and murine bone marrow–derived cells and limits inflammation by suppressing signaling through stimulatory…”
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Ingested allergens must be absorbed systemically to induce systemic anaphylaxis by Strait, Richard T., MD, Mahler, Ashley, BS, Hogan, Simon, PhD, Khodoun, Marat, PhD, Shibuya, Akira, PhD, Finkelman, Fred D., MD

“…Background IgE-mediated food allergy is a common cause of enteric disease and is responsible for approximately 100 systemic anaphylaxis deaths in the United…”
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Cγ1 Deficiency Exacerbates Collagen‐Induced Arthritis by Strait, Richard T., Thornton, Sherry, Finkelman, Fred D.

“…Objective IgG antibodies protect by aggregating pathogens and activating complement and stimulatory Fcγ receptors (FcγR). Although IgG1 accounts for a large…”
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IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking by Strait, Richard T, Morris, Suzanne C, Finkelman, Fred D

“…Although it has long been hypothesized that allergen immunotherapy inhibits allergy, in part, by inducing production of IgG Abs that intercept allergens before…”
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Increased nasal epithelial cell responsiveness to IL‐17A in paediatric asthmatics with low blood neutrophil count, low traffic‐related air pollution exposure and good asthma control by McAlees, Jaclyn W., Baker, Theresa, Houshel, Lauren, McKnight, Christopher, Lindsley, Andrew, Strait, Richard T., Zhang, Xue, Cannata, Angela, Biagini, Jocelyn M., Butsch Kovacic, Melinda, Lewkowich, Ian P.

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Peanuts can contribute to anaphylactic shock by activating complement by Khodoun, Marat, PhD, Strait, Richard, MD, Orekov, Tatyana, MS, Hogan, Simon, PhD, Karasuyama, Hajime, PhD, Herbert, De'Broski R., PhD, Köhl, Jörg, MD, Finkelman, Fred D., MD

“…Background Peanut allergy is the most common food-related cause of lethal anaphylaxis and, unlike other food allergies, typically persists into adulthood…”
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Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions by Epp, Alexandra, Hobusch, Juliane, Bartsch, Yannic C., Petry, Janina, Lilienthal, Gina-Maria, Koeleman, Carolien A.M., Eschweiler, Simon, Möbs, Christian, Hall, Ashley, Morris, Suzanne C., Braumann, Dominique, Engellenner, Christine, Bitterling, Josephine, Rahmöller, Johann, Leliavski, Alexei, Thurmann, Robina, Collin, Mattias, Moremen, Kelley W., Strait, Richard T., Blanchard, Véronique, Petersen, Arnd, Gemoll, Timo, Habermann, Jens K., Petersen, Frank, Nandy, Andreas, Kahlert, Helga, Hertl, Michael, Wuhrer, Manfred, Pfützner, Wolfgang, Jappe, Uta, Finkelman, Fred D., Ehlers, Marc

“…[...]it seems advisable to select adjuvants for new AIT protocols1,E25,E26 for their ability to promote sialylated IgG(4) antibody responses. Peak identity was…”
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IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity by Forbes, Elizabeth E, Groschwitz, Katherine, Abonia, J Pablo, Brandt, Eric B, Cohen, Elizabeth, Blanchard, Carine, Ahrens, Richard, Seidu, Luqman, McKenzie, Andrew, Strait, Richard, Finkelman, Fred D, Foster, Paul S, Matthaei, Klaus I, Rothenberg, Marc E, Hogan, Simon P

“…Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the…”
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Preferential production of IgG1, IL-4 and IL-10 in MuSK-immunized mice by Ulusoy, Canan, Kim, Eunmi, Tüzün, Erdem, Huda, Ruksana, Yılmaz, Vuslat, Poulas, Konstantinos, Trakas, Nikos, Skriapa, Lamprini, Niarchos, Athanasios, Strait, Richard T, Finkelman, Fred D, Turan, Selin, Zisimopoulou, Paraskevi, Tzartos, Socrates, Saruhan-Direskeneli, Güher, Christadoss, Premkumar

“…Abstract Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness associated with acetylcholine receptor (AChR), muscle-specific…”
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Differential roles for the IL-9/IL-9 receptor α-chain pathway in systemic and oral antigen–induced anaphylaxis by Osterfeld, Heather, BSc, Ahrens, Richard, BSc, Strait, Richard, MD, Finkelman, Fred D., MD, Renauld, Jean-Christophe, PhD, Hogan, Simon P., PhD

“…Background The cytokine IL-9 has been implicated in allergic reactions, including food allergy, but its contribution to parenteral versus oral antigen–induced…”
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