Search Results - "Strain, Matthew C."

Highly precise measurement of HIV DNA by droplet digital PCR by Strain, Matthew C, Lada, Steven M, Luong, Tiffany, Rought, Steffney E, Gianella, Sara, Terry, Valeri H, Spina, Celsa A, Woelk, Christopher H, Richman, Douglas D

“…Deoxyribonucleic acid (DNA) of the human immunodeficiency virus (HIV) provides the most sensitive measurement of residual infection in patients on effective…”
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Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies by Eriksson, Susanne, Graf, Erin H, Dahl, Viktor, Strain, Matthew C, Yukl, Steven A, Lysenko, Elena S, Bosch, Ronald J, Lai, Jun, Chioma, Stanley, Emad, Fatemeh, Abdel-Mohsen, Mohamed, Hoh, Rebecca, Hecht, Frederick, Hunt, Peter, Somsouk, Ma, Wong, Joseph, Johnston, Rowena, Siliciano, Robert F, Richman, Douglas D, O'Doherty, Una, Palmer, Sarah, Deeks, Steven G, Siliciano, Janet D

“…HIV-1 reservoirs preclude virus eradication in patients receiving highly active antiretroviral therapy (HAART). The best characterized reservoir is a small,…”
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HIV Type 1 (HIV-1) Proviral Reservoirs Decay Continuously Under Sustained Virologic Control in HIV-1-Infected Children Who Received Early Treatment by LUZURIAGA, Katherine, TABAK, Barbara, CUNNINGHAM, Coleen K, PERSAUD, Deborah, GARBER, Manuel, YA HUI CHEN, ZIEMNIAK, Carrie, MCMANUS, Margaret M, MURRAY, Danielle, STRAIN, Matthew C, RICHMAN, Douglas D, CHUN, Tae-Wook

“…Early initiation of combination antiretroviral therapy (cART) to human immunodeficiency virus type 1 (HIV-1)-infected infants controls HIV-1 replication and…”
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Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations by Oliveira, Michelli F, Chaillon, Antoine, Nakazawa, Masato, Vargas, Milenka, Letendre, Scott L, Strain, Matthew C, Ellis, Ronald J, Morris, Sheldon, Little, Susan J, Smith, Davey M, Gianella, Sara

“…Even when antiretroviral therapy (ART) is started early after infection, HIV DNA might persist in the central nervous system (CNS), possibly contributing to…”
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A Novel Assay to Measure the Magnitude of the Inducible Viral Reservoir in HIV-infected Individuals by Procopio, Francesco Andrea, Fromentin, Rémi, Kulpa, Deanna A., Brehm, Jessica H., Bebin, Anne-Gaelle, Strain, Matthew C., Richman, Douglas D., O'Doherty, Una, Palmer, Sarah, Hecht, Frederick M., Hoh, Rebecca, Barnard, Richard J.O., Miller, Michael D., Hazuda, Daria J., Deeks, Steven G., Sékaly, Rafick-Pierre, Chomont, Nicolas

“…Quantifying latently infected cells is critical to evaluate the efficacy of therapeutic strategies aimed at reducing the size of the long-lived viral…”
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In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells by Wong, Joseph K, Strain, Matthew C, Porrata, Rodin, Reay, Elizabeth, Sankaran-Walters, Sumathi, Ignacio, Caroline C, Russell, Theresa, Pillai, Satish K, Looney, David J, Dandekar, Satya

“…The CD8+ T-cell is a key mediator of antiviral immunity, potentially contributing to control of pathogenic lentiviral infection through both innate and…”
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Associations between Virologic and Immunologic Dynamics in Blood and in the Male Genital Tract by GIANELIA, Sara, STRAIN, Matthew C, ROUGHT, Steffney E, VARGAS, Milenka V, LITTLE, Susan J, RICHMAN, Douglas D, SPINA, Celsa A, SMITH, Davey M

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Effect of Treatment, during Primary Infection, on Establishment and Clearance of Cellular Reservoirs of HIV-1 by Strain, Matthew C., Little, Susan J., Daar, Eric S., Havlir, Diane V., Günthard, Huldrych F., Lam, Ruby Y., Daly, Otto A., Nguyen, Juin, Ignacio, Caroline C., Spina, Celsa A., Richman, Douglas D., Wong, Joseph K.

“…Patients in whom virologic suppression is achieved with highly active antiretroviral therapy (HAART) retain long-lived cellular reservoirs of human…”
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Decreased HIV Type 1 Transcription in CCR5-Δ32 Heterozygotes During Suppressive Antiretroviral Therapy by Wang, Charlene, Abdel-Mohsen, Mohamed, Strain, Matthew C., Lada, Steven M., Yukl, Steven, Cockerham, Leslie R., Pilcher, Christopher D., Hecht, Frederick M., Sinclair, Elizabeth, Liegler, Teri, Richman, Douglas D., Deeks, Steven G., Pillai, Satish K.

“…Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency…”
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Productive Infection Maintains a Dynamic Steady State of Residual Viremia in Human Immunodeficiency Virus Type 1-Infected Persons Treated with Suppressive Antiretroviral Therapy for Five Years by Havlir, Diane V, Strain, Matthew C, Clerici, Mario, Ignacio, Caroline, Trabattoni, Daria, Ferrante, Pasquale, Wong, Joseph K

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Achieving Linear Scaling for the Electronic Quantum Coulomb Problem by Strain, Matthew C., Scuseria, Gustavo E., Frisch, Michael J.

“…The computation of the electron-electron Coulomb interaction is one of the limiting factors in ab initio electronic structure calculations. The computational…”
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Increase in 2-Long Terminal Repeat Circles and Decrease in D-dimer After Raltegravir Intensification in Patients With Treated HIV Infection: A Randomized, Placebo-Controlled Trial by Hatano, Hiroyu, Strain, Matthew C., Scherzer, Rebecca, Bacchetti, Peter, Wentworth, Deborah, Hoh, Rebecca, Martin, Jeffrey N., McCune, Joseph M., Neaton, James D., Tracy, Russell P., Hsue, Priscilla Y., Richman, Douglas D., Deeks, Steven G.

“…Background. The degree to which human immunodeficiency virus (HIV) continues to replicate during antiretroviral therapy (ART) is controversial. We conducted a…”
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HIV-1 Expression Within Resting CD4⁺ T Cells After Multiple Doses of Vorinostat by Archin, Nancy M., Bateson, Rosalie, Tripathy, Manoj K., Crooks, Amanda M., Yang, Kuo-Hsiung, Dahl, Noelle P., Kearney, Mary F., Anderson, Elizabeth M., Coffin, John M., Strain, Matthew, Richman, Douglas D., Robertson, Kevin R., Kashuba, Angela D., Bosch, Ronald J., Hazuda, Daria J., Kuruc, Joann D., Eron, Joseph J., Margolis, David M.

“…Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4⁺ T cells of treated,…”
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Predictors of Residual Viremia in HIV-Infected Patients Successfully Treated with Efavirenz and Lamivudine plus either Tenofovir or Stavudine by Havlir, Diane V., Koelsch, Kersten K., Strain, Matthew C., Margot, Nicolas, Lu, Biao, Ignacio, Caroline C., Miller, Michael D., Wong, Joseph K.

“…In human immunodeficiency virus (HIV)–infected patients successfully treated with highly active antiretroviral therapy (HAART), a low level of HIV RNA persists…”
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Replication of Human Herpesviruses Is Associated with Higher HIV DNA Levels during Antiretroviral Therapy Started at Early Phases of HIV Infection by Gianella, Sara, Anderson, Christy M, Var, Susanna R, Oliveira, Michelli F, Lada, Steven M, Vargas, Milenka V, Massanella, Marta, Little, Susan J, Richman, Douglas D, Strain, Matthew C, Pérez-Santiago, Josué, Smith, Davey M

“…Asymptomatic replication of human herpesviruses (HHV) is frequent in HIV-infected men and is associated with increased T-cell activation and HIV disease…”
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Defective proviruses rapidly accumulate during acute HIV-1 infection by Bruner, Katherine M, Murray, Alexandra J, Pollack, Ross A, Soliman, Mary G, Laskey, Sarah B, Capoferri, Adam A, Lai, Jun, Strain, Matthew C, Lada, Steven M, Hoh, Rebecca, Ho, Ya-Chi, Richman, Douglas D, Deeks, Steven G, Siliciano, Janet D, Siliciano, Robert F

“…Bruner et al . report that defective HIV-1 proviruses predominate in early infection, even when antiretroviral therapy is initiated in the first months after…”
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Relative efficacy of T cell stimuli as inducers of productive HIV-1 replication in latently infected CD4 lymphocytes from patients on suppressive cART by Beliakova-Bethell, Nadejda, Hezareh, Marjan, Wong, Joseph K, Strain, Matthew C, Lewinski, Mary K, Richman, Douglas D, Spina, Celsa A

“…Abstract Quantification of cell-associated replication-competent HIV, in blood samples from patients with undetectable plasma viremia, requires specialized…”
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Select host restriction factors are associated with HIV persistence during antiretroviral therapy by Abdel-Mohsen, Mohamed, Wang, Charlene, Strain, Matthew C, Lada, Steven M, Deng, Xutao, Cockerham, Leslie R, Pilcher, Christopher D, Hecht, Frederick M, Liegler, Teri, Richman, Douglas D, Deeks, Steven G, Pillai, Satish K

“…OBJECTIVE:The eradication of HIV necessitates elimination of the HIV latent reservoir. Identifying host determinants governing latency and reservoir size in…”
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Evaluation of the Aptima HIV-1 Quant Dx Assay for HIV-1 RNA Quantitation in Different Biological Specimen Types by Yek, Christina, Massanella, Marta, Peling, Tashi, Lednovich, Kristen, Nair, Sangeetha V, Worlock, Andrew, Vargas, Milenka, Gianella, Sara, Ellis, Ronald J, Strain, Matthew C, Busch, Michael P, Nugent, C Thomas, Richman, Douglas D

“…The search for a cure for HIV infection has highlighted the need for increasingly sensitive and precise assays to measure viral burden in various tissues and…”
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New assays for monitoring residual HIV burden in effectively treated individuals by Strain, Matthew C, Richman, Douglas D

“…PURPOSE OF REVIEWMeasurements of HIV burden have relied upon quantification of viral nucleic acids by real-time PCR (qPCR). To develop and test strategies for…”
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