Search Results - "Strain, Martin"

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction by England, Elizabeth, Rees, D. Gareth, Scott, Ian Christopher, Carmen, Sara, Chan, Denice T. Y., Chaillan Huntington, Catherine E., Houslay, Kirsty F., Erngren, Teodor, Penney, Mark, Majithiya, Jayesh B., Rapley, Laura, Sims, Dorothy A., Hollins, Claire, Hinchy, Elizabeth C., Strain, Martin D., Kemp, Benjamin P., Corkill, Dominic J., May, Richard D., Vousden, Katherine A., Butler, Robin J., Mustelin, Tomas, Vaughan, Tristan J., Lowe, David C., Colley, Caroline, Cohen, E. Suzanne

“…Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for…”
Get full text

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation by Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas

“…In response to infections and irritants, the respiratory epithelium releases the alarmin interleukin (IL)-33 to elicit a rapid immune response. However, little…”
Get full text

Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils by Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, An, Ling-Ling, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, 3rd, Clifton O, Sampson, Kevon, Darrah, Erika, Siegel, Richard M, Hasni, Sarfaraz, Andrade, Felipe, Vousden, Katherine A, Mustelin, Tomas, Sims, Gary P

“…Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein…”
Get full text

Tailored amino acid diversity for the evolution of antibody affinity by González-Muñoz, Andrea, Bokma, Evert, O'Shea, Desmond, Minton, Kevin, Strain, Martin, Vousden, Katherine, Rossant, Christine, Jermutus, Lutz, Minter, Ralph

“…Antibodies are a unique class of proteins with the ability to adapt their binding sites for high affinity and high specificity to a multitude of antigens. Many…”
Get full text

In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection by Tkaczyk, Christine, Newton, Michael, Patnaik, Mun Mun, Thom, George, Strain, Martin, Gamson, Adam, Daramola, Olalekan, Murthy, Andal, Douthwaite, Julie, Stepanov, Oleg, Boger, Elin, Yang, Haitao, Esser, Mark T, Lidwell, Ashley, DiGiandomenico, Antonio, Santos, Luis, Sellman, Bret R

“…Single monoclonal antibodies (mAbs) can be expressed in vivo through gene delivery of their mRNA formulated with lipid nanoparticles (LNPs). However, delivery…”
Get more information

Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 by Vousden, Katherine A., Lundqvist, Tomas, Popovic, Bojana, Naiman, Brian, Carruthers, Alan M., Newton, Philip, Johnson, Daniel J. D., Pomowski, Anja, Wilkinson, Trevor, Dufner, Patrick, de Mendez, Isabelle, Mallinder, Philip R., Murray, Clare, Strain, Martin, Connor, Jane, Murray, Lynne A., Sleeman, Matthew A., Lowe, David C., Huntington, James A., Vaughan, Tristan J.

“…Plasminogen activator inhibitor-1 (PAI-1) is a serine protease inhibitor (serpin) that regulates fibrinolysis, cell adhesion and cell motility via its…”
Get full text

Spontaneous secretion of peptidyl-arginine deiminase 2 and cell surface exposure of peptidyl-arginine deiminase 4 by neutrophils by Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, Clifton O, Sampson, Kevon, Darrah, Erika, Bowen, Michael, Andrade, Felipe, Vousden, Katherine, Sims, Gary P, Mustelin, Tomas Mikael

“…Abstract Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA) and elevated levels of protein…”
Get full text

Development of a homogeneous high-throughput screening assay for biological inhibitors of human rhinovirus infection by Newton, Philip, O'Shea, Desmond, Wells, Edward, Moakes, Kerry, Dunmore, Rebecca, Butler, Robin J, Wilkinson, Trevor, Ward, Alison, Casson, Nigel, Strain, Martin, Vousden, Katherine, Lowe, David C, Pattison, Debbie V, Carruthers, Alan M, Sleeman, Matthew A, Vaughan, Tristan J, Harrison, Paula

“…Infection with human rhinovirus (HRV) is thought to result in acute respiratory exacerbations of chronic obstructive pulmonary disorder (COPD). Consequently,…”
Get more information