Search Results - "Strahlendorf, J"

AMPA-induced excitotoxicity increases nuclear levels of CAD, endonuclease G, and acinus and induces chromatin condensation in rat hippocampal pyramidal neurons by Henne, W M, Oomman, S, Attridge, J, Finckbone, V, Coates, P, Bliss, R, Strahlendorf, H, Strahlendorf, J

“…Programmed cell death has been linked to AMPA-receptor-mediated excitotoxicity in pyramidal neurons of the hippocampus. The intent of this study was to…”
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AMPA receptor-mediated alterations of intracellular calcium homeostasis in rat cerebellar Purkinje cells in vitro : Correlates to dark cell degeneration by STRAHLENDORF, J. C, BRANDON, T, MILES, R, STRAHLENDORF, H. K

“…In the rat cerebellar slice preparation in vitro, excessive DL-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA)-receptor activation elicits a…”
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A transient voltage-dependent outward potassium current in mammalian cerebellar Purkinje cells by Wang, Y, Strahlendorf, J C, Strahlendorf, H K

“…Utilizing the single electrode voltage clamp technique applied to rat Purkinje cells (PCs), we have recorded a transient outward voltage-dependent potassium…”
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Diazoxide and cyclothiazide convert AMPA-induced dark cell degeneration of Purkinje cells to edematous damage in the cerebellar slice by Strahlendorf, Jean C., Acosta, Steve, Strahlendorf, Howard K.

“…Using the in vitro cerebellar slice preparation from young rats (8–12 days old), AMPA produced in addition to dark cell degeneration (DCD), an edematous type…”
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Serotonin alters an inwardly rectifying current (Ih) in rat cerebellar Purkinje cells under voltage clamp by Li, S J, Wang, Y, Strahlendorf, H K, Strahlendorf, J C

“…The effects of serotonin (5-HT) on the hyperpolarization-activated sodium-potassium inward current (H-current: Ih) were examined in cerebellar Purkinje cells…”
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Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha 7 nicotinic receptor by Strahlendorf, J C, Acosta, S, Miles, R, Strahlendorf, H K

“…The objective of the present study was to assess the contribution of sodium influx to development of dark cell degeneration (DCD) in Purkinje neurons (PNs)…”
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Modulatory role of serotonin on GABA-elicited inhibition of cerebellar Purkinje cells by Strahlendorf, J C, Lee, M, Strahlendorf, H K

“…The present study was designed to directly examine the postsynaptic actions of serotonin on GABA-mediated inhibition of cerebellar Purkinje cells. The findings…”
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Ionic contributions to the oscillatory firing activity of rat Purkinje cells in vitro by Chang, W, Strahlendorf, J C, Strahlendorf, H K

“…Oscillatory firing activity in cerebellar Purkinje cells (PCs) can be maintained by intrinsic ionic conductances in the apparent absence of excitatory and…”
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Serotonin reduces a voltage-dependent transient outward potassium current and enhances excitability of cerebellar Purkinje cells by Wang, Y, Strahlendorf, J C, Strahlendorf, H K

“…Utilizing current-clamp and single electrode voltage-clamp techniques we have studied the actions of serotonin (5-HT) on a transient outward voltage-dependent…”
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Effects of serotonin and the 5-HT2/1C receptor agonist DOI on neurons of the cerebellar dentate/interpositus nuclei: possible involvement of a GABAergic interneuron by Cumming-Hood, P A, Strahlendorf, H K, Strahlendorf, J C

“…The present study was designed to examine the effects of iontophoretically applied serotonin (5-HT) on neurons of the cerebellar dentate/interpositus nuclei in…”
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Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro by Darrow, E J, Strahlendorf, H K, Strahlendorf, J C

“…These studies were undertaken in an attempt to classify the receptor subtypes mediating the inhibitory effects of serotonin (5-HT) on cerebellar Purkinje cells…”
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Modulatory action of serotonin on glutamate-induced excitation of cerebellar Purkinje cells by Lee, M, Strahlendorf, J C, Strahlendorf, H K

“…The effects of serotonin (5-hydroxytryptamine, 5-HT) on glutamate-induced excitation of Purkinje cells were examined. Pulsatile iontophoretic applications of…”
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Effects of serotonin on cerebellar Purkinje cells are dependent on the baseline firing rate by STRAHLENDORF, J. C, LEE, M, STRAHLENDORF, H. K

“…Serotonin applied iontophoretically to cerebellar Purkinje cells elicited one of three effects: inhibition (62% of the cells), biphasic response (27%), and…”
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Serotonin modulates muscimol- and baclofen-elicited inhibition of cerebellar Purkinje cells by Strahlendorf, J C, Lee, M H, Strahlendorf, H K

“…The present study was designed to test whether serotonin (5-HT) preferentially affects the GABAA or GABAB receptor subtypes in the cerebellum using muscimol…”
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Bergmann glia utilize active caspase-3 for differentiation by Oomman, Sowmini, Strahlendorf, Howard, Dertien, Janet, Strahlendorf, Jean

“…Recently, functions associated with caspase have been modified from their well-established role in apoptosis. Although caspases are still regarded as mediators…”
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Extracellular magnesium concentration alters Purkinje cell responsiveness to serotonin and analogues by Darrow, E, Strahlendorf, J C, Strahlendorf, H K

“…Binding studies have shown that divalent cations increase the affinity of 5-hydroxytryptamine 1A (5-HT1A) receptors for ligands. The present study compared the…”
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Serotonin depresses excitatory amino acid-induced excitation of cerebellar Purkinje cells in the adult rat in vivo by Netzeband, J G, Weathers, L B, Strahlendorf, H K, Strahlendorf, J C

“…The modulatory effects of serotonin (5-HT) on excitatory amino acid (EAA)-induced excitations of Purkinje cells (PCs) were examined in urethane-anesthetized…”
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Differential effects of N-methyl-D-aspartic acid and L-homocysteic acid on cerebellar Purkinje neurons by Lee, M, Strahlendorf, H K, Strahlendorf, J C

“…The effects of N-methyl-D-aspartic acid (NMDA) and L-homocysteic acid (LH) were measured on cerebellar Purkinje neurons. In urethane-anesthetized rats,…”
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Enhancement of cerebellar Purkinje cell complex discharge activity by microiontophoretic serotonin by STRAHLENDORF, J. C, STRAHLENDORF, H. K, LEE, M

“…The major finding of the present study is that iontophoretically applied serotonin increased markedly (average 94.0%) the number of complex discharges within…”
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Enduring changes in Purkinje cell electrophysiology following transient exposure to AMPA: correlates to dark cell degeneration by Strahlendorf, Jean C, Strahlendorf, Howard K

“…Purkinje cells (PCs) are selectively vulnerable to α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-mediated delayed toxicity that is manifested as…”
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