Search Results - "Straehla, Joelle P"

Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery by Boehnke, Natalie, Straehla, Joelle P, Safford, Hannah C, Kocak, Mustafa, Rees, Matthew G, Ronan, Melissa, Rosenberg, Danny, Adelmann, Charles H, Chivukula, Raghu R, Nabar, Namita, Berger, Adam G, Lamson, Nicholas G, Cheah, Jaime H, Li, Hojun, Roth, Jennifer A, Koehler, Angela N, Hammond, Paula T

“…To accelerate the translation of cancer nanomedicine, we used an integrated genomic approach to improve our understanding of the cellular processes that govern…”
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Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing by Boehnke, Natalie, Correa, Santiago, Hao, Liangliang, Wang, Wade, Straehla, Joelle P., Bhatia, Sangeeta N., Hammond, Paula T.

“…Layer‐by‐layer nanoparticles (NPs) are modular drug delivery vehicles that incorporate multiple functional materials through sequential deposition of…”
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Pharmacokinetic Principles and Their Application to Central Nervous System Tumors by Straehla, Joelle P., Warren, Katherine E.

“…Despite increasing knowledge of the biologic drivers of central nervous system tumors, most targeted agents trialed to date have not shown activity against…”
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Trafficking through the blood–brain barrier is directed by core and outer surface components of layer‐by‐layer nanoparticles by Lamson, Nicholas G., Pickering, Andrew J., Wyckoff, Jeffrey, Ganesh, Priya, Calle, Elizabeth A., Straehla, Joelle P., Hammond, Paula T.

“…Drug‐carrying nanoparticles are a promising strategy to deliver therapeutics into the brain, but their translation requires better characterization of…”
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A predictive microfluidic model of human glioblastoma to assess trafficking of blood-brain barrier-penetrant nanoparticles by Straehla, Joelle P, Hajal, Cynthia, Safford, Hannah C, Offeddu, Giovanni S, Boehnke, Natalie, Dacoba, Tamara G, Wyckoff, Jeffrey, Kamm, Roger D, Hammond, Paula T

“…The blood–brain barrier represents a significant challenge for the treatment of high-grade gliomas, and our understanding of drug transport across this…”
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Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain by Pickering, Andrew J., Lamson, Nicholas G., Marand, Michael H., Hwang, Wei, Straehla, Joelle P., Hammond, Paula T.

“…Glioblastoma is characterized by diffuse infiltration into surrounding healthy brain tissues, which makes it challenging to treat. Complete surgical resection…”
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Correction to “Layer-by-Layer Polymer Functionalization Improves Nanoparticle Penetration and Glioblastoma Targeting in the Brain” by Pickering, Andrew J., Lamson, Nicholas G., Marand, Michael H., Huang, Wei, Straehla, Joelle P., Hammond, Paula T.

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Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions by Anchordoquy, Thomas, Artzi, Natalie, Balyasnikova, Irina V., Barenholz, Yechezkel, La-Beck, Ninh M., Brenner, Jacob S., Chan, Warren C. W., Decuzzi, Paolo, Exner, Agata A., Gabizon, Alberto, Godin, Biana, Lai, Samuel K., Lammers, Twan, Mitchell, Michael J., Moghimi, S. Moein, Muzykantov, Vladimir R., Peer, Dan, Nguyen, Juliane, Popovtzer, Rachela, Ricco, Madison, Serkova, Natalie J., Singh, Ravi, Schroeder, Avi, Schwendeman, Anna A., Straehla, Joelle P., Teesalu, Tambet, Tilden, Scott, Simberg, Dmitri

“…In recent years, steady progress has been made in synthesizing and characterizing engineered nanoparticles, resulting in several approved drugs and multiple…”
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The Benefits and Burdens of Cancer: A Prospective Longitudinal Cohort Study of Adolescents and Young Adults by Straehla, Joelle P, Barton, Krysta S, Yi-Frazier, Joyce P, Wharton, Claire, Baker, Kevin Scott, Bona, Kira, Wolfe, Joanne, Rosenberg, Abby R

“…Adolescents and early young adults (AYAs) with cancer are at high risk for poor outcomes. Positive psychological responses such as benefit-finding may buffer…”
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The Blood-Brain Barrier: Implications for Experimental Cancer Therapeutics by Straehla, Joelle P, Reardon, David A, Wen, Patrick Y, Agar, Nathalie Y.R

“…The blood-brain barrier is critically important for the treatment of both primary and metastatic cancers of the central nervous system (CNS). Clinical outcomes…”
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Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing by Boehnke, Natalie, Correa, Santiago, Hao, Liangliang, Wang, Wade, Straehla, Joelle P., Bhatia, Sangeeta N., Hammond, Paula T.

“…Layer‐by‐layer nanoparticles (NPs) are modular drug delivery vehicles that incorporate multiple functional materials through sequential deposition of…”
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Rücktitelbild: Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. 7/2020) by Boehnke, Natalie, Correa, Santiago, Hao, Liangliang, Wang, Wade, Straehla, Joelle P., Bhatia, Sangeeta N., Hammond, Paula T.

“…Geschichtete, mit Protease‐responsiven Peptid‐Biomarkern funktionalisierte und mit siRNA beladene Nanopartikel ermöglichen die nicht‐invasive Harn‐Diagnostik…”
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Nanomechanical Probes of Single Corneal Epithelial Cells: Shear Stress and Elastic Modulus by Straehla, Joelle P, Limpoco, F. T, Dolgova, Natalia V, Keselowsky, Benjamin G, Sawyer, W. Gregory, Perry, Scott S

“…Living human corneal epithelial cells have been probed in vitro via atomic force microscopy, revealing the frictional characteristics of single cells. Under…”
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DIPG-08. PROBING THE BLOOD-BRAIN-TUMOR-BARRIER WITH A MICROVASCULAR MODEL OF DIFFUSE MIDLINE GLIOMA by Bennett, Kimberly R, Teboh, Tessy, Hajal, Cynthia, Kamm, Roger D, Hammond, Paula T, Straehla, Joelle P

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SURG-03. LAYER-BY-LAYER CORE-SHELL NANOPARTICLES FOR THE DELIVERY OF HDAC INHIBITORS TO THE CENTRAL NERVOUS SYSTEM by Marand, Michael H, Han, Emily, Kim, Seung Hyun, Hammond, Paula T, Straehla, Joelle P

“…Abstract Diffuse midline gliomas (DMGs) present unique challenges in pediatric cancer care. The location of DMGs often renders the tumor inoperable and…”
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DIPG-29. PHENOTYPIC SCREENS IDENTIFY GENETIC REGULATORS OF NANOPARTICLE DELIVERY IN DIFFUSE MIDLINE GLIOMAS by Tsai, Jessica W, Coppola, Marissa, Kenny-Serrano, Julianna, Doench, John G, Hammond, Paula T, Bandopadhayay, Pratiti, Straehla, Joelle P

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Abstract 309: Development of a multi-omic, pooled cancer cell screen for nanoparticle delivery by Straehla, Joelle P., Boehnke, Natalie, Kocak, Mustafa, Ronan, Melissa, Safford, Hannah, Rees, Matthew G., Roth, Jennifer A., Koehler, Angela N., Hammond, Paula T.

“…Abstract Background: Nanoparticles (NPs) hold enormous promise for the targeted delivery of therapeutics for cancer, but clinical translation is lacking…”
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Back Cover: Theranostic Layer‐by‐Layer Nanoparticles for Simultaneous Tumor Detection and Gene Silencing (Angew. Chem. Int. Ed. 7/2020) by Boehnke, Natalie, Correa, Santiago, Hao, Liangliang, Wang, Wade, Straehla, Joelle P., Bhatia, Sangeeta N., Hammond, Paula T.

“…Layer‐by‐layer nanoparticles functionalized with protease‐responsive peptide biomarkers and loaded with siRNA mediate noninvasive urinary‐based diagnostics in…”
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SCIDOT-28. TARGETED NANOPARTICLES FOR IMPROVED DRUG DELIVERY TO MEDULLOBLASTOMA by Straehla, Joelle P, Boehnke, Natalie, Dacoba, Tamara G, Hammond, Paula T

“…Abstract Platinum-based agents remain a key component of therapy for children with medulloblastoma, despite significant systemic side effects and only modest…”
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DDEL-04. ENGINEERED NANOCARRIERS TO ENHANCE DRUG DELIVERY ACROSS THE BLOOD-BRAIN BARRIER by Straehla, Joelle P, Hajal, Cynthia, Safford, Hannah, Offeddu, Giovanni, Wyckoff, Jeffrey, Kamm, Roger D, Hammond, Paula T

“…Abstract Pediatric central nervous system tumors are the leading cause of cancer death in children. Promising therapeutics have been identified, but the…”
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