Search Results - "Stradecki, Holly M."

Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5 by Morris-Blanco, Kahlilia C., Dave, Kunjan R., Saul, Isabel, Koronowski, Kevin B., Stradecki, Holly M., Perez-Pinzon, Miguel A.

“…Sirtuin 5 (SIRT5) is a mitochondrial-localized NAD + -dependent lysine desuccinylase and a major regulator of the mitochondrial succinylome. We wanted to…”
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Sexually Dimorphic Diet-Induced Insulin Resistance in Obese Tissue Inhibitor of Metalloproteinase-2 (TIMP-2)-Deficient Mice by Jaworski, Diane M, Sideleva, Olga, Stradecki, Holly M, Langlois, Garret D, Habibovic, Aida, Satish, Basanthi, Tharp, William G, Lausier, James, LaRock, Kyla, Jetton, Thomas L, Peshavaria, Mina, Pratley, Richard E

“…We report an MMP/TIMP-deficient mouse in which both sexes develop obesity when fed a standard chow diet. Circulating levels of matrix metalloproteinases (MMPs)…”
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Metabolomics Based Identification of SIRT5 and Protein Kinase C Epsilon Regulated Pathways in Brain by Koronowski, Kevin B, Khoury, Nathalie, Morris-Blanco, Kahlilia C, Stradecki-Cohan, Holly M, Garrett, Timothy J, Perez-Pinzon, Miguel A

“…The role of Sirtuins in brain function is emerging, yet little is known about SIRT5 in this domain. Our previous work demonstrates that protein kinase C…”
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Cognitive Deficits after Cerebral Ischemia and Underlying Dysfunctional Plasticity: Potential Targets for Recovery of Cognition by Stradecki-Cohan, Holly M, Cohan, Charles H, Raval, Ami P, Dave, Kunjan R, Reginensi, Diego, Gittens, Rolando A, Youbi, Mehdi, Perez-Pinzon, Miguel A

“…Cerebral ischemia affects millions of people worldwide and survivors suffer from long-term functional and cognitive deficits. While stroke and cardiac arrest…”
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Protein Kinase C Delta Modulates Endothelial Nitric Oxide Synthase after Cardiac Arrest by Lin, Hung Wen, Gresia, Victoria L, Stradecki, Holly M, Alekseyenko, Aleksey, Dezfulian, Cameron, Neumann, Jake T, Dave, Kunjan R, Perez-Pinzon, Miguel A

“…We previously showed that inhibition of protein kinase C delta (PKCδ) improves brain perfusion 24 hours after asphyxial cardiac arrest (ACA) and confers…”
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Differential aminoacylase expression in neuroblastoma by Long, Patrick M., Stradecki, Holly M., Minturn, Jane E., Wesley, Umadevi V., Jaworski, Diane M.

“…Neuroblastoma, a cancer of the sympathetic nervous system, is the most common extracranial solid tumor in children. MYCN amplification and increased BDNF/TrkB…”
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Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance by Koronowski, Kevin B, Khoury, Nathalie, Saul, Isabel, Loris, Zachary B, Cohan, Charles H, Stradecki-Cohan, Holly M, Dave, Kunjan R, Young, Juan I, Perez-Pinzon, Miguel A

“…BACKGROUND AND PURPOSE—Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when…”
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Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia by Stradecki-Cohan, Holly M, Youbi, Mehdi, Cohan, Charles H, Saul, Isa, Garvin, Alexandra A, Perez, Edwin, Dave, Kunjan R, Wright, Clinton B, Sacco, Ralph L, Perez-Pinzon, Miguel A

“…BACKGROUND AND PURPOSE—Preclinical studies suggest that exercise can enhance cognition after cerebral ischemia but often use long training regiments and test…”
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Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization by Cohan, Charles H, Stradecki-Cohan, Holly M, Morris-Blanco, Kahlilia C, Khoury, Nathalie, Koronowski, Kevin B, Youbi, Mehdi, Wright, Clinton B, Perez-Pinzon, Miguel A

“…Global cerebral ischemia is a debilitating injury that damages the CA1 region of the hippocampus, an area important for learning and memory. Protein kinase C…”
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Abstract TP267: Protein Kinase C Epsilon-activation Mediates Ischemic Neuroprotection by Activating an Activity-regulated Cytoskeleton-associated Protein-dependent Mechanism by Cohan, Charles H, Stradecki, Holly M, Morris-Blanco, Kahlilia C, Khoury, Nathalie, Koronowski, Kevin B, Youbi, Mehdi, Wright, Clinton B, Perez-Pinzon, Miguel A

“…Abstract only Introduction: Cerebral ischemia can trigger cell death in the CA1 region of the hippocampus, an area important for memory. Protein kinase C…”
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Abstract TP98: Moderate Physical Exercise Promotes Cognitive Recovery Following Focal Cerebral Ischemia in Rats by Youbi, Mehdi, Cohan, Charles H, Stradecki, Holly M, Tiozzo, Eduard, Dave, Kunjan R, Wright, Clinton B, Sacco, Ralph L, Perez-Pinzon, Miguel A

“…Abstract only The majority of stroke patients suffer long-term disabilities impacting both motor and cognitive function. Physical exercise has been shown to…”
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Hyperphagia and Leptin Resistance in Tissue Inhibitor of Metalloproteinase-2 Deficient Mice by Stradecki, H. M., Jaworski, D. M.

“…Obesity is a complex genetic and behavioural disorder arising from the improper integration of peripheral signals at central autonomic centres. For the…”
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Physical Exercise Improves Cognitive Outcomes in Two Models of Transient Cerebral Ischemia by Stradecki-Cohan, Holly M., Youbi, Mehdi, Cohan, Charles H., Saul, Isa, Garvin, Alexandra A., Perez, Edwin, Dave, Kunjan R., Wright, Clinton B., Sacco, Ralph L., Perez-Pinzon, Miguel A.

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