Search Results - "Stracke, Jan Olaf"

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle by Niewoehner, Jens, Bohrmann, Bernd, Collin, Ludovic, Urich, Eduard, Sade, Hadassah, Maier, Peter, Rueger, Petra, Stracke, Jan Olaf, Lau, Wilma, Tissot, Alain C, Loetscher, Hansruedi, Ghosh, Anirvan, Freskgård, Per-Ola

“…Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB)…”
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Assessment of disulfide and hinge modifications in monoclonal antibodies by Moritz, Bernd, Stracke, Jan Olaf

“…During the last years there was a substantial increase in the use of antibodies and related proteins as therapeutics. The emphasis of the pharmaceutical…”
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Quantifying methionine sulfoxide in therapeutic protein formulation excipients as sensitive oxidation marker by Fevre, Arnaud, Kiessig, Steffen, Bonnington, Lea, Olaf Stracke, Jan, Bulau, Patrick

“…•Simple, sensitive, and robust liquid chromatography method for the trace level quantification of methionine sulfoxide in complex therapeutic antibody…”
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Application of affinity capillary electrophoresis for charge heterogeneity profiling of biopharmaceuticals by Hutanu, Andrei, Kiessig, Steffen, Bathke, Andrea, Ketterer, Rolf, Riner, Sonja, Olaf Stracke, Jan, Wild, Markus, Moritz, Bernd

“…Charge heterogeneity profiling is important for the quality control (QC) of biopharmaceuticals. Because of the increasing complexity of these therapeutic…”
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Screening techniques for monitoring the sub-visible particle formation of free fatty acids in biopharmaceuticals by Chen, Wei, Klemm, Denis, Gregoritza, Kathrin, Satya Krishna Kishore, Ravuri, Olaf Stracke, Jan, Wurth, Christine, Pinto, Cosimo, Sancho Oltra, Nuria

“…[Display omitted] Free fatty acid (FFA) particles that originate from the enzymatic hydrolysis of polysorbate (PS) via co-purified host cell proteins generally…”
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Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures by Diepold, Katharina, Bomans, Katrin, Wiedmann, Michael, Zimmermann, Boris, Petzold, Andreas, Schlothauer, Tilman, Mueller, Robert, Moritz, Bernd, Stracke, Jan Olaf, Mølhøj, Michael, Reusch, Dietmar, Bulau, Patrick

“…The degradation of proteins by asparagine deamidation and aspartate isomerization is one of several chemical degradation pathways for recombinant antibodies…”
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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies by Schlothauer, Tilman, Rueger, Petra, Stracke, Jan Olaf, Hertenberger, Hubert, Fingas, Felix, Kling, Lothar, Emrich, Thomas, Drabner, Georg, Seeber, Stefan, Auer, Johannes, Koch, Stefan, Papadimitriou, Apollon

“…The neonatal Fc receptor (FcRn) is important for the metabolic fate of IgG antibodies in vivo. Analysis of the interaction between FcRn and IgG in vitro might…”
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Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25) by English, William Roger, Velasco, Gloria, Stracke, Jan Olaf, Knäuper, Vera, Murphy, Gillian

“…This study describes the biochemical characterisation of the catalytic domain of membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP25, leukolysin). Its…”
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Comparison of Protein-like Model Particles Fabricated by Micro 3D Printing to Established Standard Particles by Amara, Ilias, Germershaus, Oliver, Lentes, Christopher, Sass, Steffen, Youmto, Stephany Mamdjo, Stracke, Jan Olaf, Clemens-Hemmelmann, Mirjam, Assfalg, Anacelia

“…Innovative analytical instruments and development of new methods has provided a better understanding of protein particle formation in biopharmaceuticals but…”
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Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry by Kuhne, Felix, Heinrich, Katrin, Winter, Martin, Fichtl, Jürgen, Hoffmann, Gabriel, Zähringer, Franziska, Spitzauer, Katharina, Meier, Monika, Khan, Tarik A., Bonnington, Lea, Wagner, Katharina, Stracke, Jan Olaf, Reusch, Dietmar, Wegele, Harald, Mormann, Michael, Bulau, Patrick

“…Antibody combination therapies have become viable therapeutic treatment options for certain severe diseases such as cancer. The co-formulation production…”
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Evaluation of protein drug stability with vitreous humor in a novel ex-vivo intraocular model by Patel, Sulabh, Müller, Gerd, Stracke, Jan Olaf, Altenburger, Ulrike, Mahler, Hanns-Christian, Jere, Dhananjay

“…[Display omitted] The stability of protein therapeutics during the residence time in the vitreous humor (VH) is an important consideration for intra ocular…”
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Prediction of intraocular antibody drug stability using ex-vivo ocular model by Patel, Sulabh, Stracke, Jan Olaf, Altenburger, Ulrike, Mahler, Hanns-Christian, Metzger, Philipp, Shende, Pankaj, Jere, Dhananjay

“…[Display omitted] Following intravitreal (IVT) injection, therapeutic proteins get exposed to physiological pH, temperature and components in the vitreous…”
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Increasing robustness, reliability and storage stability of critical reagents by freeze-drying by Emrich, Thomas, Stracke, Jan Olaf, Guo, Xiaoying, Damhjell, Kari, Moelleken, Joerg, Vogel, Rudolf, Stubenrauch, Kay-Gunnar, Staack, Roland F

“…Stabilization of critical reagents by freeze-drying would facilitate storage and transportation at ambient temperatures, and simultaneously enable constant…”
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