Search Results - "Strack, Peter"

Inhibition of Notch Signaling Reduces the Stem-like Population of Breast Cancer Cells and Prevents Mammosphere Formation by GRUDZIEN, Peter, LO, Shelly, ALBAIN, Kathy S, ROBINSON, Patricia, RAJAN, Prabha, STRACK, Peter R, GOLDE, Todd E, MIELE, Lucio, FOREMAN, Kimberly E

“…Cancer stem cells (CSCs) are believed to be responsible for breast cancer formation and recurrence; therefore, therapeutic strategies targeting CSCs must be…”
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Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung by YUANBIN CHEN, DE MARCO, Melissa A, GRAZIANI, Irene, GAZDAR, Adi F, STRACK, Peter R, MIELE, Lucio, BOCCHETTA, Maurizio

“…NOTCH signaling is an evolutionarily conserved signaling pathway that regulates cell fate during development and postnatal life. It has been increasingly…”
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Opposite effects of Notch-1 and Notch-2 on mesothelioma cell survival under hypoxia are exerted through the Akt pathway by Graziani, Irene, Eliasz, Sandra, De Marco, Melissa A, Chen, Yuanbin, Pass, Harvey I, De May, Richard M, Strack, Peter R, Miele, Lucio, Bocchetta, Maurizio

“…Malignant mesothelioma (MM) is a cancer of the lining of the lungs, heart, and intestine and is known to respond poorly to chemotherapy. Here we show that…”
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Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression by Stivers, Peter J, Harmonay, Lauren, Hicks, Alexandra, Mehmet, Huseyin, Morris, Melody, Robinson, Gain M, Strack, Peter R, Savage, Mary J, Zaller, Dennis M, Zwierzynski, Izabela, Brandish, Philip E

“…Glucocorticoid signaling regulates target genes by multiple mechanisms, including the repression of transcriptional activities of nuclear factor…”
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Inhibition of NOTCH Signaling by Gamma Secretase Inhibitor Engages the RB Pathway and Elicits Cell Cycle Exit in T-Cell Acute Lymphoblastic Leukemia Cells by RAO, Sudhir S, O'NEIL, Jennifer, VAN DER PLOEG, Lex H. T, CARROLL, Pamela M, DRAETTA, Giulio F, LOOK, A. Thomas, STACK, Peter R, WINTER, Christopher G, LIBERATOR, Cole D, HARDWICK, James S, XUDONG DAI, ZHANG, Theresa, TYMINSKI, Edyta, JING YUAN, KOHL, Nancy E, RICHON, Victoria M

“…NOTCH signaling is deregulated in the majority of T-cell acute lymphoblastic leukemias (T-ALL) as a result of activating mutations in NOTCH1. Gamma secretase…”
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Downregulation of Notch Pathway by a γ-Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model by EFFERSON, Clay L, WINKELMANN, Christopher T, BUSER, Carolyn, YEATMAN, Timothy, COPPOLA, Domenico, WINTER, Christopher, CLARK, Edwin A, DRAETTA, Giulio F, STRACK, Peter R, MAJUMDER, Pradip K, WARE, Christopher, SULLIVAN, Timothy, GIAMPAOLI, Saverio, TAMMAM, Jennifer, PATEL, Shailendra, MESITI, Giuseppe, REILLY, John F, GIBSON, Raymond E

“…ERBB2/neu and Notch signaling are known to be deregulated in many human cancers. However, pathway cross-talk and dependencies are not well understood. In this…”
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A zinc finger nuclease assay to rapidly quantitate homologous recombination proficiency in human cell lines by Yuan, Jing, Strack, Peter R., Toniatti, Carlo, Pelletier, Marc

“…Homologous recombination (HR) is a cellular mechanism for accurate repair of double-strand DNA breaks, often deregulated in cancer. Development of novel cancer…”
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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis by Booher, Robert N, Hatch, Harold, Dolinski, Brian M, Nguyen, Thi, Harmonay, Lauren, Al-Assaad, Ali-Samer, Ayers, Mark, Nebozhyn, Michael, Loboda, Andrey, Hirsch, Heather A, Zhang, Theresa, Shi, Bin, Merkel, Carrie E, Angagaw, Minilik H, Wang, Yaolin, Long, Brian J, Lennon, Xianlu Q, Miselis, Nathan, Pucci, Vincenzo, Monahan, James W, Lee, Junghoon, Kondic, Anna Georgieva, Im, Eun Kyung, Mauro, David, Blanchard, Rebecca, Gilliland, Gary, Fawell, Stephen E, Zawel, Leigh, Schuller, Alwin G, Strack, Peter

“…Dinaciclib is a potent CDK1, 2, 5 and 9 inhibitor being developed for the treatment of cancer. Additional understanding of antitumor mechanisms and…”
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Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia by Sanda, Takaomi, Li, Xiaoyu, Gutierrez, Alejandro, Ahn, Yebin, Neuberg, Donna S., O'Neil, Jennifer, Strack, Peter R., Winter, Christopher G., Winter, Stuart S., Larson, Richard S., von Boehmer, Harald, Look, A. Thomas

“…To identify dysregulated pathways in distinct phases of NOTCH1-mediated T-cell leukemogenesis, as well as small-molecule inhibitors that could synergize with…”
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Control of Cell Growth and Survival by Enzymes of the Fatty Acid Synthesis Pathway in HCT-116 Colon Cancer Cells by YANAI ZHAN, GINANNI, Nicole, TOTA, Michael R, WU, Margaret, BAYS, Nathan W, RICHON, Victoria M, KOHL, Nancy E, BACHMAN, Eric S, STRACK, Peter R, KRAUSS, Stefan

“…Purpose: For many tumor cells, de novo lipogenesis is a requirement for growth and survival. A considerable body of work suggests that inhibition of this…”
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Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres by Chen, Jie, Kesari, Santosh, Rooney, Christine, Strack, Peter R, Chen, Jihua, Shen, Huangxuan, Wu, Lizi, Griffin, James D

“…Glioblastoma (GBM) is the most common malignant brain tumor that is characterized by high proliferative rate and invasiveness. Since dysregulation of Notch…”
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Level of phosphohistone H3 among various types of human cancers by Sun, Amy, Zhou, Wei, Lunceford, Jared, Strack, Peter, Dauffenbach, Lisa M, Kerfoot, Christopher A

“…Objectives Anti-phosphorylated histone H3 (pHH3) antibodies specifically detect the core protein histone H3 only when phosphorylated at serine 10 (Ser10) or…”
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Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context by Severyn, Bryan, Nguyen, Thi, Altman, Michael D, Li, Lixia, Nagashima, Kumiko, Naumov, George N, Sathyanarayanan, Sriram, Cook, Erica, Morris, Erick, Ferrer, Marc, Arthur, Bill, Benita, Yair, Watters, Jim, Loboda, Andrey, Hermes, Jeff, Gilliland, D Gary, Cleary, Michelle A, Carroll, Pamela M, Strack, Peter, Tudor, Matt, Andersen, Jannik N

“…The RAS-MAPK pathway controls many cellular programs, including cell proliferation, differentiation, and apoptosis. In colorectal cancers, recurrent mutations…”
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Differentiation of Hdm2-Mediated p53 Ubiquitination and Hdm2 Autoubiquitination Activity by Small Molecular Weight Inhibitors by Lai, Zhihong, Yang, Tao, Kim, Young B., Sielecki, Thais M., Diamond, Melody A., Strack, Peter, Rolfe, Mark, Caligiuri, Maureen, Benfield, Pamela A., Auger, Kurt R., Copeland, Robert A.

“…The oncoprotein hdm2 ubiquitinates p53, resulting in the rapid degradation of p53 through the ubiquitin (Ub)-proteasome pathway. Hdm2-mediated destabilization…”
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3-Aryl-4-hydroxyquinolin-2(1 H)-one derivatives as type I fatty acid synthase inhibitors by Rivkin, Alexey, Kim, Yoona R., Goulet, Mark T., Bays, Nathan, Hill, Armetta D., Kariv, Ilona, Krauss, Stefan, Ginanni, Nicole, Strack, Peter R., Kohl, Nancy E., Chung, Christine C., Varnerin, Jeffrey P., Goudreau, Paul N., Chang, Amy, Tota, Michael R., Munoz, Benito

“…A series of 3-aryl-4-hydroxyquinolin-2(1 H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC 50 = 1.4 μM,…”
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Apoptosis Mediated by HIV Protease is Preceded by Cleavage of Bcl-2 by Strack, Peter R., Frey, Michelle West, Rizzo, Christopher J., Cordova, Beverly, George, Henry J., Meade, Raymond, Ho, Siew Peng, Corman, Jeanne, Tritch, Radonna, Korant, Bruce D.

“…Expression of the human immunodeficiency virus type 1 (HIV) protease in cultured cells leads to apoptosis, preceded by cleavage of bcl-2, a key negative…”
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Activation of the Multicatalytic Endopeptidase by Oxidants. Effects on Enzyme Structure by Strack, Peter R, Waxman, Lloyd, Fagan, Julie M

“…It is well established that the functional properties of proteins can be compromised by oxidative damage and, in vivo, proteins modified by oxidants are…”
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Combined Inhibition of Cyclin-Dependent Kinases (Dinaciclib) and AKT (MK-2206) Blocks Pancreatic Tumor Growth and Metastases in Patient-Derived Xenograft Models by Hu, Chaoxin, Dadon, Tikva, Chenna, Venugopal, Yabuuchi, Shinichi, Bannerji, Rajat, Booher, Robert, Strack, Peter, Azad, Nilofer, Nelkin, Barry D, Maitra, Anirban

“…KRAS is activated by mutation in the vast majority of cases of pancreatic cancer; unfortunately, therapeutic attempts to inhibit KRAS directly have been…”
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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors by O'Neil, Jennifer, Grim, Jonathan, Strack, Peter, Rao, Sudhir, Tibbitts, Deanne, Winter, Christopher, Hardwick, James, Welcker, Markus, Meijerink, Jules P, Pieters, Rob, Draetta, Giulio, Sears, Rosalie, Clurman, Bruce E, Look, A Thomas

“…gamma-secretase inhibitors (GSIs) can block NOTCH receptor signaling in vitro and therefore offer an attractive targeted therapy for tumors dependent on…”
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Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling by Lewis, Huw D., Leveridge, Matthew, Strack, Peter R., Haldon, Christine D., O'Neil, Jennifer, Kim, Hellen, Madin, Andrew, Hannam, Joanne C., Look, A. Thomas, Kohl, Nancy, Draetta, Giulio, Harrison, Timothy, Kerby, Julie A., Shearman, Mark S., Beher, Dirk

“…In this report, inhibitors of the γ-secretase enzyme have been exploited to characterize the antiproliferative relationship between target inhibition and…”
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