Search Results - "Strack, Alison M"

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes by Zhang, Liwen, McCabe, Timothy, Condra, Jon H, Ni, Yan G, Peterson, Laurence B, Wang, Weirong, Strack, Alison M, Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G, Hansen, Barbara C, Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J, Pellacani, Andrea, Sparrow, Carl P, An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S, Blom, Daniel, Sitlani, Ayesha

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report a novel antibody 1B20…”
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Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade by Hagan, M M, Rushing, P A, Pritchard, L M, Schwartz, M W, Strack, A M, Van Der Ploeg, L H, Woods, S C, Seeley, R J

“…Overexpression of agouti-related peptide (AgRP), an endogenous melanocortin (MC) 3 and 4 receptor antagonist (MC3/4-R), causes obesity. Exogenous…”
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Design and Pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a Potent, Selective, Melanocortin Subtype-4 Receptor Agonist by Sebhat, Iyassu K, Martin, William J, Ye, Zhixiong, Barakat, Khaled, Mosley, Ralph T, Johnston, David B. R, Bakshi, Raman, Palucki, Brenda, Weinberg, David H, MacNeil, Tanya, Kalyani, Rubana N, Tang, Rui, Stearns, Ralph A, Miller, Randy R, Tamvakopoulos, Constantin, Strack, Alison M, McGowan, Erin, Cashen, Doreen E, Drisko, Jennifer E, Hom, Gary J, Howard, Andrew D, MacIntyre, D. Euan, van der Ploeg, Lex H. T, Patchett, Arthur A, Nargund, Ravi P

“…Synthetic and natural peptides that act as nonselective melanocortin receptor agonists have been found to be anorexigenic and to stimulate erectile activity…”
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Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats by Shearman, Lauren P., Camacho, Ramon E., Sloan Stribling, D., Zhou, Dan, Bednarek, Maria A., Hreniuk, Donna L., Feighner, Scott D., Tan, Carina P., Howard, Andrew D., Van der Ploeg, Lex H.T., MacIntyre, D.Euan, Hickey, Gerard J., Strack, Alison M.

“…Central administration of the neuropeptide melanin-concentrating hormone (MCH) stimulates feeding in rodents. We studied the effects of intracerebroventricular…”
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Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice by Bradbury, Margaret J, Campbell, Una, Giracello, Darlene, Chapman, Deborah, King, Chris, Tehrani, Lida, Cosford, Nicholas D P, Anderson, Jeff, Varney, Mark A, Strack, Alison M

“…The metabotropic glutamate receptor subtype mGlu5 modulates central reward pathways. Many transmitter systems within reward pathways affect feeding. We…”
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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S] by Strack, Alison M., Carballo-Jane, Ester, Wang, Sheng-ping, Xue, Jiyan, Ping, Xiaoli, McNamara, Lesley Ann, Thankappan, Anil, Price, Olga, Wolff, Michael, Wu, T.J., Kawka, Douglas, Mariano, Michele, Burton, Charlotte, Chang, Ching H., Chen, Jing, Menke, John, Luell, Silvi, Zycband, Emanuel I., Tong, Xinchun, Raubertas, Richard, Sparrow, Carl P., Hubbard, Brian, Woods, John, O'Neill, Gary, Waters, M. Gerard, Sitlani, Ayesha

“…The use of nicotinic acid to treat dyslipidemia is limited by induction of a “flushing” response, mediated in part by the interaction of prostaglandin D2…”
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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity by Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc, Lanza, Thomas J, Chang, Linda, Kelly, Theresa M, Kan, Yanqing, Palyha, Oksana, Guan, Xiao-Ming, Marsh, Donald J, Metzger, Joseph M, Gorski, Judith N, Raustad, Kate, Wang, Sheng-Ping, Strack, Alison M, Miller, Randy, Pang, Jianmei, Madeira, Maria, Lyons, Kathy, Dragovic, Jasminka, Reitman, Marc L, Nargund, Ravi P, Lin, Linus S

“…Extensive structure–activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzodiazepine sulfonamide series, led…”
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Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice by Zhou, Dan, Shen, Zhu, Strack, Alison M., Marsh, Donald J., Shearman, Lauren P.

“…Mch1r-deficient ( Mch1r −/−) mice are hyperphagic, hyperactive, lean, and resistant to diet-induced obesity. To examine whether the MCH1R is involved in…”
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From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9 by Petrilli, Whitney L, Adam, Gregory C, Erdmann, Roman S, Abeywickrema, Pravien, Agnani, Vijayalakshmi, Ai, Xi, Baysarowich, Jen, Byrne, Noel, Caldwell, John P, Chang, Wonsuk, DiNunzio, Edward, Feng, Zhe, Ford, Rachael, Ha, Sookhee, Huang, Yongcheng, Hubbard, Brian, Johnston, Jennifer M, Kavana, Michael, Lisnock, Jean-Marie, Liang, Rui, Lu, Jun, Lu, Zhijian, Meng, Juncai, Orth, Peter, Palyha, Oksana, Parthasarathy, Gopal, Salowe, Scott P, Sharma, Sujata, Shipman, Jennifer, Soisson, Stephen M, Strack, Alison M, Youm, Hyewon, Zhao, Kake, Zink, Deborah L, Zokian, Hratch, Addona, George H, Akinsanya, Karen, Tata, James R, Xiong, Yusheng, Imbriglio, Jason E

“…Proprotein convertase substilisin-like/kexin type 9 (PCSK9) is a serine protease involved in a protein-protein interaction with the low-density lipoprotein…”
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Modulation of Metabolic Syndrome by Fibroblast Growth Factor 19 (FGF19)? by Strack, Alison M, Myers, Robert W

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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity by MacNeil, Douglas J., Howard, Andrew D., Guan, Xiaoming, Fong, Tung M., Nargund, Ravi P., Bednarek, Maria A., Goulet, Mark T., Weinberg, David H., Strack, Alison M., Marsh, Donald J., Chen, Howard Y., Shen, Chun-Pyn, Chen, Airu S., Rosenblum, Charles I., MacNeil, Tanya, Tota, Michael, MacIntyre, Euan D., Van der Ploeg, Lex H.T.

“…Five G-protein-coupled melanocortin receptors (MC 1–MC 5) are expressed in mammalian tissues. The melanocortin receptors support diverse physiological…”
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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia[S] by Yin, Wu, Carballo-Jane, Ester, McLaren, David G., Mendoza, Vivienne H., Gagen, Karen, Geoghagen, Neil S., McNamara, Lesley Ann, Gorski, Judith N., Eiermann, George J., Petrov, Aleksandr, Wolff, Michael, Tong, Xinchun, Wilsie, Larissa C., Akiyama, Taro E., Chen, Jing, Thankappan, Anil, Xue, Jiyan, Ping, Xiaoli, Andrews, Genevieve, Wickham, L. Alexandra, Gai, Cesaire L., Trinh, Tu, Kulick, Alison A., Donnelly, Marcie J., Voronin, Gregory O., Rosa, Ray, Cumiskey, Anne-Marie, Bekkari, Kavitha, Mitnaul, Lyndon J., Puig, Oscar, Chen, Fabian, Raubertas, Richard, Wong, Peggy H., Hansen, Barbara C., Koblan, Ken S., Roddy, Thomas P., Hubbard, Brian K, Strack, Alison M.

“…In an attempt to understand the applicability of various animal models to dyslipidemia in humans and to identify improved preclinical models for target…”
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The role of melanocortins in body weight regulation: opportunities for the treatment of obesity by MacNeil, Douglas J., Howard, Andrew D., Guan, Xiaoming, Fong, Tung M., Nargund, Ravi P., Bednarek, Maria A., Goulet, Mark T., Weinberg, David H., Strack, Alison M., Marsh, Donald J., Chen, Howard Y., Shen, Chun-Pyn, Chen, Airu S., Rosenblum, Charles I., MacNeil, Tanya, Tota, Michael, MacIntyre, Euan D., Van der Ploeg, Lex H.T.

“…Five G-protein-coupled melanocortin receptors (MC 1–MC 5) are expressed in mammalian tissues. The melanocortin receptors support diverse physiological…”
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11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice by Hermanowski-Vosatka, Anne, Balkovec, James M., Cheng, Kang, Chen, Howard Y., Hernandez, Melba, Koo, Gloria C., Le Grand, Cheryl B., Li, Zhihua, Metzger, Joseph M., Mundt, Steven S., Noonan, Heather, Nunes, Christian N., Olson, Steven H., Pikounis, Bill, Ren, Ning, Robertson, Nancy, Schaeffer, James M., Shah, Kashmira, Springer, Martin S., Strack, Alison M., Strowski, Matthias, Wu, Kenneth, Wu, TsueiJu, Xiao, Jianying, Zhang, Bei B., Wright, Samuel D., Thieringer, Rolf

“…The enzyme 11β–hydroxysteroid dehydrogenase (HSD) type 1 converts inactive cortisone into active cortisol in cells, thereby raising the effective…”
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Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity by Nargund, Ravi P, Strack, Alison M, Fong, Tung M

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Glucocorticoids, chronic stress, and obesity by Dallman, Mary F, Pecoraro, Norman C, La Fleur, Susanne E, Warne, James P, Ginsberg, Abigail B, Akana, Susan F, Laugero, Kevin C, Houshyar, Hani, Strack, Alison M, Bhatnagar, Seema, Bell, Mary E

“…Glucocorticoids either inhibit or sensitize stress-induced activity in the hypothalamo-pituitary-adrenal (HPA) axis, depending on time after their…”
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Regulation of Energy Homeostasis by Bombesin Receptor Subtype-3: Selective Receptor Agonists for the Treatment of Obesity by Guan, Xiao-Ming, Chen, Howard, Dobbelaar, Peter H., Dong, Yan, Fong, Tung M., Gagen, Karen, Gorski, Judith, He, Shuwen, Howard, Andrew D., Jian, Tianying, Jiang, Michael, Kan, Yanqing, Kelly, Theresa M., Kosinski, Jennifer, Lin, Linus S., Liu, Jian, Marsh, Donald J., Metzger, Joseph M., Miller, Randy, Nargund, Ravi P., Palyha, Oksana, Shearman, Lauren, Shen, Zhu, Stearns, Ralph, Strack, Alison M., Stribling, Sloan, Tang, Yui Sing, Wang, Sheng-Ping, White, Amanda, Yu, Hong, Reitman, Marc L.

“…Bombesin receptor subtype 3 (BRS-3) is a G protein coupled receptor whose natural ligand is unknown. We developed potent, selective agonist (Bag-1, Bag-2) and…”
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Melanin-Concentrating Hormone 1 Receptor-Deficient Mice are Lean, Hyperactive, and Hyperphagic and Have Altered Metabolism by Marsh, Donald J., Weingarth, Drew T., Novi, Dawn E., Chen, Howard Y., Trumbauer, Myrna E., Chen, Airu S., Guan, Xiao-Ming, Jiang, Michael M., Feng, Yue, Camacho, Ramon E., Shen, Zhu, Frazier, Easter G., Yu, Hong, Metzger, Joseph M., Kuca, Stephanie J., Shearman, Lauren P., Gopal-Truter, Shobhna, MacNeil, Douglas J., Strack, Alison M., MacIntyre, D. Euan, Lex H. T. Van der Ploeg, Qian, Su

“…Melanin-concentrating hormone (MCH) is a cyclic 19-aa hypothalamic neuropeptide derived from a larger prohormone precursor of MCH (Pmch), which also encodes…”
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Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice by Shearman, Lauren P, Wang, Sheng-Ping, Helmling, Steffen, Stribling, D. Sloan, Mazur, Paul, Ge, Lan, Wang, Liyang, Klussmann, Sven, Macintyre, D. Euan, Howard, Andrew D, Strack, Alison M

“…Ghrelin, an acylated peptide secreted from the stomach, acts as a short-term signal of nutrient depletion. Ghrelin is an endogenous ligand for the GH…”
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Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass by Van der Ploeg, Lex H.T, Chen, Airu S, Marsh, Donald J, Trumbauer, Myrna E, Frazier, Easter G, Guan, Xiao-Ming, Yu, Hong, Rosenblum, Charles I, Vongs, Aurawan, Feng, Yue, Cao, Linhai, Metzger, Joseph M, Strack, Alison M, Camacho, Ramon E, Mellin, Theodore N, Nunes, Christian N, Min, William, Fisher, Jill, Gopal-Truter, Shobhna, MacIntyre, D. Euan, Chen, Howard Y

“…Genetic and pharmacological studies have defined a role for the melanocortin-4 receptor (Mc4r) in the regulation of energy homeostasis. The physiological…”
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