Search Results - "Strachan, Briony C"

Author Correction: A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma by Xia, Hui, Strachan, Briony C., Gifford, Sean C., Shevkoplyas, Sergey S.

Get full text

A high-throughput microfluidic approach for 1000-fold leukocyte reduction of platelet-rich plasma by Xia, Hui, Strachan, Briony C., Gifford, Sean C., Shevkoplyas, Sergey S.

“…Leukocyte reduction of donated blood products substantially reduces the risk of a number of transfusion-related complications. Current ‘leukoreduction’ filters…”
Get full text

A portable system for processing donated whole blood into high quality components without centrifugation by Gifford, Sean C, Strachan, Briony C, Xia, Hui, Vörös, Eszter, Torabian, Kian, Tomasino, Taylor A, Griffin, Gary D, Lichtiger, Benjamin, Aung, Fleur M, Shevkoplyas, Sergey S

“…The use of centrifugation-based approaches for processing donated blood into components is routine in the industrialized world, as disparate storage conditions…”
Get full text

Improved expansion of T cells in culture when isolated with an equipment-free, high-throughput, flow-through microfluidic module versus traditional density gradient centrifugation by Strachan, BRIONY C, XIA, HUI, VÖRÖS, ESZTER, GIFFORD, SEAN C, SHEVKOPLYAS, SERGEY S

“…Highlights • Flow-through device recovers more lymphocytes than density gradient centrifugation. • Cell recoveries were 85% CD3+, 89% CD19+ and 97% CD56+ with…”
Get full text

Centrifugation‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells by Vörös, Eszter, Piety, Nathaniel Z., Strachan, Briony C., Lu, Madeleine, Shevkoplyas, Sergey S.

“…Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation‐based cell processors commonly used by hospital…”
Get full text

New Detection Modality for Label-Free Quantification of DNA in Biological Samples via Superparamagnetic Bead Aggregation by Leslie, Daniel C, Li, Jingyi, Strachan, Briony C, Begley, Matthew R, Finkler, David, Bazydlo, Lindsay A. L, Barker, N. Scott, Haverstick, Doris M, Utz, Marcel, Landers, James P

“…Combining DNA and superparamagnetic beads in a rotating magnetic field produces multiparticle aggregates that are visually striking, enabling label-free…”
Get full text

Dual-force aggregation of magnetic particles enhances label-free quantification of DNA at the sub-single cell level by Nelson, Daniel A., Strachan, Briony C., Sloane, Hillary S., Li, Jingyi, Landers, James P.

“…•We have developed a multiplex system for bead-based DNA quantification.•Novel combination of agitation and rotating magnetic field.•We demonstrate high…”
Get full text

A simple integrated microfluidic device for the multiplexed fluorescence-free detection of Salmonella enterica by Strachan, Briony C, Sloane, Hillary S, Houpt, Eric, Lee, Jacob C, Miranian, Daniel C, Li, Jingyi, Nelson, Daniel A, Landers, James P

“…Rapid, inexpensive and simplistic nucleic acid testing (NAT) is pivotal in delivering biotechnology solutions at the point-of-care (POC). We present a…”
Get more information

Investigation of the DNA target design parameters for effective hybridization-induced aggregation of particles for the sequence-specific detection of DNA by Strachan, Briony C, Sloane, Hillary S, Lee, Jacob C, Leslie, Daniel C, Landers, James P

“…In a recent publication, we presented a label-free method for the detection of specific DNA sequences through the hybridization-induced aggregation (HIA) of a…”
Get more information

Washing in hypotonic saline reduces the fraction of irreversibly-damaged cells in stored blood: a proof-of-concept study by Xia, Hui, Khanal, Grishma, Strachan, Briony C, Vörös, Eszter, Piety, Nathaniel Z, Gifford, Sean C, Shevkoplyas, Sergey S

“…During hypothermic storage, a substantial fraction of red blood cells (RBCs) transforms from flexible discocytes to rigid sphero-echinocytes and spherocytes…”
Get full text

Dual-Domain Microchip-Based Process for Volume Reduction Solid Phase Extraction of Nucleic Acids from Dilute, Large Volume Biological Samples by Reedy, Carmen R, Hagan, Kristin A, Strachan, Briony C, Higginson, Joshua J, Bienvenue, Joan M, Greenspoon, Susan A, Ferrance, Jerome P, Landers, James P

“…A microfluidic device was developed to carry out integrated volume reduction and purification of nucleic acids from dilute, large volume biological samples…”
Get full text

Platinum nanoparticle-facilitated reflective surfaces for non-contact temperature control in microfluidic devices for PCR amplification by Leslie, Daniel C, Seker, Erkin, Bazydlo, Lindsay A L, Strachan, Briony C, Landers, James P

“…The polymerase chain reaction (PCR) is critical for amplification of target sequences of DNA or RNA that have clinical, biological or forensic relevance. While…”
Get more information

Volume reduction solid phase extraction of DNA from dilute, large-volume biological samples by Reedy, Carmen R, Bienvenue, Joan M, Coletta, Lisa, Strachan, Briony C, Bhatri, Naila, Greenspoon, Susan, Landers, James P

“…Abstract Microdevices are often designed to process sample volumes on the order of tens of microliters and cannot typically accommodate larger volume samples…”
Get full text

Quantitative planar array screen of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis by Vanarsa, Kamala, Soomro, Sanam, Zhang, Ting, Strachan, Briony, Pedroza, Claudia, Nidhi, Malavika, Cicalese, Pietro, Gidley, Christopher, Dasari, Shobha, Mohan, Shree, Thai, Nathan, Truong, Van Thi Thanh, Jordan, Nicole, Saxena, Ramesh, Putterman, Chaim, Petri, Michelle, Mohan, Chandra

“…The goal of these studies is to discover novel urinary biomarkers of lupus nephritis (LN). Urine from systemic lupus erythematosus (SLE) patients was…”
Get more information

A New Centrifugation-Free Approach for Reducing IgA Levels in Units of Stored Red Blood Cells by Vörös, Eszter, Piety, Nathaniel Z., Strachan, Briony C., Shevkoplyas, Sergey S.

“…Introduction: Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients when RBCs from IgA-deficient donors are not…”
Get full text

Centrifugation-free washing: a novel approach for removing IgA from stored red blood cells by Vörös, Eszter, Piety, Nathaniel Z., Strachan, Briony C., Lu, Madeleine, Shevkoplyas, Sergey S.

“…Washed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation-based cell processors commonly used by hospital…”
Get full text

Towards a Closed System for Extracting Lymphocytes from Whole Blood by Vörös, Eszter, Strachan, Briony C., Xia, Hui, Griffin, Gary D., Aung, Fleur M., Lichtiger, Benjamin, Gifford, Sean C., Shevkoplyas, Sergey S.

“…Introduction: Cellular therapies promise new treatment options and potentially curative efficacy for a wide array of acute and chronic diseases. The ability to…”
Get full text

A Portable System for Processing Donated Whole Blood into High Quality Components without Centrifugation by Gifford, Sean C., Strachan, Briony C., Xia, Hui, Vörös, Eszter, Torabian, Kian, Tomasino, Taylor A., Griffin, Gary D., Lichtiger, Benjamin, Aung, Fleur M., Shevkoplyas, Sergey S.

“…Introduction: Centrifugation is the cornerstone of blood processing because it has been the only technology capable of separating large volumes of whole blood…”
Get full text

A Novel High-Throughput Microfluidic Technology for Isolating Lymphocytes from Buffy Coats for Allogeneic Cellular Therapies by Strachan, Briony C., Vörös, Eszter, Xia, Hui, Griffin, Gary D., Lichtiger, Benjamin, Aung, Fleur M., Gifford, Sean C., Shevkoplyas, Sergey S.

“…Introduction: Adoptive immunotherapies involving infusion of third-party donor-derived T lymphocytes (T-cells) to treat life-threatening viral infections…”
Get full text