Nonalcoholic fatty liver disease in children with obesity- observations from one clinical centre in the Western Pomerania region

Nonalcoholic fatty liver disease in children with obesity- observations from one clinical centre in the Western Pomerania region

Nonalcoholic fatty liver disease (NAFLD) is a growing health problem in the pediatric population, due to the constantly increasing percentage of children with obesity. The objective of the study was to assess the occurrence of NAFLD based on ultrasound (USG) analysis and the use of alanine aminotran...

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Published in:Frontiers in endocrinology (Lausanne) Vol. 13; p. 992264
Main Authors: Marcinkiewicz, Katarzyna, Horodnicka-Józwa, Anita, Jackowski, Tomasz, Strączek, Kamila, Biczysko-Mokosa, Agnieszka, Walczak, Mieczysław, Petriczko, Elżbieta
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 31-10-2022
Subjects:
ALT
Child
Diabetes Mellitus, Type 2
Endocrinology
fatty liver
glucose intolerance
Glucose Intolerance - epidemiology
Humans
NAFLD
Non-alcoholic Fatty Liver Disease - diagnostic imaging
Non-alcoholic Fatty Liver Disease - epidemiology
obesity
Obesity - complications
Obesity - epidemiology
Overweight
Retrospective Studies
glucose intolerance
ALT
NAFLD
fatty liver
obesity
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Summary:Nonalcoholic fatty liver disease (NAFLD) is a growing health problem in the pediatric population, due to the constantly increasing percentage of children with obesity. The objective of the study was to assess the occurrence of NAFLD based on ultrasound (USG) analysis and the use of alanine aminotransferase (ALT) in children with overweight and obesity depending on glucose tolerance. Medical records of 228 consecutive patients aged 2-18 years with overweight and obesity were reviewed retrospectively. Based on the oral glucose tolerance test children were divided into groups according to the severity of carbohydrate metabolism disorders. ALT, lipid parameters and insulin sensitivity indices HOMA, Matsuda and Quicki were analyzed. NAFLD was diagnosed (based on the USG) in 51 patients (23.61%) - the incidence in the impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) group was significantly higher when compared to ones without glucose intolerance. Because of extreme values of metabolic parameters in TDM2 children being outliers, they were not considered in the statistical analysis of the study. 22 (11.58%) patients had elevated ALT values, of which 12 (54.55%) had hepatic steatosis features on ultrasound. 72.73% (n=32) patients with fatty liver features on USG had ALT values considered normal with cut-off point 42 U/l accepted in this study. Almost every fourth obese child in the study group presents features of fatty liver in ultrasound examination. Although ultrasound is not recommended by North American For Pediatric Gastroenterology, Hepatology &Nutrition(NASPGHAN) for the diagnosis of NAFLD in children, it allows identifying a high percentage of children with features of fatty liver. This percentage increases significantly in children with glucose intolerance.
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Edited by: Malgorzata Gabriela Wasniewska, University of Messina, Italy
Reviewed by: Pawel Matusik, Medical University of Silesia in Katowice, Poland; Mariella Valenzise, University of Messina, Italy; Valeria Calcaterra, University of Pavia, Italy
This article was submitted to Pediatric Endocrinology, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.992264