Search Results - "Strøbaek, D"

The Ca2+-activated K+ channel of intermediate conductance: a molecular target for novel treatments? by Jensen, B S, Strøbaek, D, Olesen, S P, Christophersen, P

“…This review discusses the Ca2+-activated K+ channels of intermediate conductance (IK channels), and their historical discovery in erythrocytes, their classical…”
Get more information

KCNQ4 channel activation by BMS-204352 and retigabine by Schrøder, Rikke Louise, Jespersen, Thomas, Christophersen, Palle, Strøbæk, Dorte, Jensen, Bo Skaaning, Olesen, Søren-Peter

“…Activation of potassium channels generally reduces cellular excitability, making potassium channel openers potential drug candidates for the treatment of…”
Get full text

Pharmacological characterization of small‐conductance Ca2+‐activated K+ channels stably expressed in HEK 293 cells by Strøbæk, Dorte, Jørgensen, Tino D, Christophersen, Palle, Ahring, Philip K, Olesen, Søren‐Peter

“…Three genes encode the small‐conductance Ca2+‐activated K+ channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed the…”
Get full text

Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas by Hélix, N, Strøbaek, D, Dahl, B H, Christophersen, P

“…The endogenous volume-regulated anion channel (VRAC) from HEK293 cells was pharmacologically characterized using the whole-cell patch-clamp technique. Under…”
Get full text

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+‐activated K+ channels by Hougaard, C, Eriksen, B L, Jørgensen, S, Johansen, T H, Dyhring, T, Madsen, L S, Strøbæk, D, Christophersen, P

“…Background and purpose: Positive modulators of small conductance Ca2+‐activated K+ channels (SK1, SK2, and SK3) exert hyperpolarizing effects that influence…”
Get full text

Cloning, expression, and distribution of a Ca(2+)-activated K+ channel beta-subunit from human brain by Tseng-Crank, J, Godinot, N, Johansen, T E, Ahring, P K, Strøbaek, D, Mertz, R, Foster, C D, Olesen, S P, Reinhart, P H

“…We have cloned and expressed a Ca(2+)-activated K+ channel beta-subunit from human brain. The open reading frame encodes a 191-amino acid protein possessing…”
Get full text

NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease by Strøbæk, D, Brown, D T, Jenkins, D P, Chen, Y-J, Coleman, N, Ando, Y, Chiu, P, Jørgensen, S, Demnitz, J, Wulff, H, Christophersen, P

“…The K(Ca) 3.1 channel is a potential target for therapy of immune disease. We identified a compound from a new chemical class of K(Ca) 3.1 inhibitors and…”
Get full text

Stable expression of the human large‐conductance Ca2+‐activated K+ channel α‐ and β‐subunits in HEK293 cells by Ahring, Philip K., Strøbæk, Dorte, Christophersen, Palle, Olesen, Søren-Peter, Johansen, Teit E.

“…We have generated HEK293 cell lines stably expressing high levels of either the human BK channel α‐subunit alone or the BK channel α‐subunit and β‐subunit…”
Get full text

Modulation of the Ca2+-dependent K+ channel, hslo, by the substituted diphenylurea NS 1608, paxilline and internal Ca2 by STRØBAEK, D, CHRISTOPHERSEN, P, HOLM, N. R, MOLDT, P, AHRING, P. K, JOHANSEN, T. E, OLESEN, S.-P

Get full text

ATP activates K and Cl channels via purinoceptor-mediated release of Ca2+ in human coronary artery smooth muscle by Strøbaek, D, Christophersen, P, Dissing, S, Olesen, S P

“…Coronary artery smooth muscle cells express G protein-coupled purinoceptors, and we report here for the first time how receptor activation by extracellular ATP…”
Get full text

Activation of the human, intermediate-conductance, Ca2+-activated K+ channel by methylxanthines by Schrøder, R L, Jensen, B S, Strøbaek, D, Olesen, S P, Christophersen, P

“…This study demonstrated that the methylxanthines, theophylline, IBMX and caffeine, activate the human, intermediate-conductance, Ca2+-activated K+ channel…”
Get full text

Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels by Korsgaard, M P G, Hartz, B P, Brown, W D, Ahring, P K, Strøbaek, D, Mirza, N R

“…Neuronal Kv7 channels are recognized as potential drug targets for treating hyperexcitability disorders such as pain, epilepsy, and mania. Hyperactivity of the…”
Get more information

NS6180, a new KCa3.1 channel inhibitor prevents T‐cell activation and inflammation in a rat model of inflammatory bowel disease by Strøbæk, D, Brown, DT, Jenkins, DP, Chen, Y‐J, Coleman, N, Ando, Y, Chiu, P, Jørgensen, S, Demnitz, J, Wulff, H, Christophersen, P

“…Background and Purpose The KCa3.1 channel is a potential target for therapy of immune disease. We identified a compound from a new chemical class of KCa3.1…”
Get full text

An ERG Channel Inhibitor from the Scorpion Buthus eupeus by Korolkova, Yuliya V., Kozlov, Sergey A., Lipkin, Aleksey V., Pluzhnikov, Kirill A., Hadley, Jennifer K., Filippov, Alexander K., Brown, David A., Angelo, Kamilla, Strøbæk, Dorte, Jespersen, Thomas, Olesen, Søren-Peter, Jensen, Bo S., Grishin, Eugene V.

“…The isolation of the peptide inhibitor of M-type K+ current, BeKm-1, from the venom of the Central Asian scorpion Buthus eupeus has been described previously…”
Get full text

P2‐purinoceptor‐mediated formation of inositol phosphates and intracellular Ca2+ transients in human coronary artery smooth muscle cells by Strøbæk, Dorte, Olesen, Søren‐Peter, Christophersen, Palle, Dissing, Steen

“…1 . The effects of extracellular adenosine 5′‐triphosphate (ATP) on smooth muscles are mediated by a variety of purinoceptors. In this study we addressed the…”
Get full text

A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo by Hougaard, C, Fraser, M O, Chien, C, Bookout, A, Katofiasc, M, Jensen, B S, Rode, F, Bitsch-Nørhave, J, Teuber, L, Thor, K B, Strøbaek, D, Burgard, E C, Rønn, L C B

“…Calcium-activated potassium channels are attractive targets for the development of therapeutics for overactive bladder. In the current study, we addressed the…”
Get more information

Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells by Strøbaek, D, Jørgensen, T D, Christophersen, P, Ahring, P K, Olesen, S P

“…Three genes encode the small-conductance Ca(2+)-activated K(+) channels (SK channels). We have stably expressed hSK1 and rSK2 in HEK 293 cells and addressed…”
Get full text

Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352 by Schrøder, Rikke Louise, Strøbaek, Dorte, Olesen, Søren-Peter, Christophersen, Palle

“…The compound BMS-204352 has been targeted for use against acute ischemic stroke, due to its activation of the large-conductance Ca2+-activated K-channel (BK)…”
Get full text

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions by Nausch, Bernhard, Rode, Frederik, Jørgensen, Susanne, Nardi, Antonio, Korsgaard, Mads P G, Hougaard, Charlotte, Bonev, Adrian D, Brown, William D, Dyhring, Tino, Strøbæk, Dorte, Olesen, Søren-Peter, Christophersen, Palle, Grunnet, Morten, Nelson, Mark T, Rønn, Lars C B

“…Large-conductance Ca(2+)-activated K(+) channels (BK, KCa1.1, MaxiK) are important regulators of urinary bladder function and may be an attractive therapeutic…”
Get more information

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) by Strøbaek, Dorte, Teuber, Lene, Jørgensen, Tino D, Ahring, Philip K, Kjaer, Katrine, Hansen, Rie S, Olesen, Søren Peter, Christophersen, Palle, Skaaning-Jensen, Bo

“…We have identified and characterized the compound NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime) as a potent activator of human Ca2+ -activated K+ channels…”
Get full text