Search Results - "Strömberg, Kia"

Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells by Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel by Zhang, Si Min, Paulin, Cynthia B.J., Shu, Huazhang, Yagüe-Capilla, Miriam, Michel, Maurice, Marttila, Petra, Ortis, Florian, Bwanika, Henri Colyn, Dirks, Christopher, Venkatram, Rajagopal Papagudi, Wiita, Elisée, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Hormann, Femke M., Koolmeister, Tobias, Linde, Erika, Lee, Sun, Llona-Minguez, Sabin, Haraldsson, Martin, Axelsson, Hanna, Strömberg, Kia, Homan, Evert J., Scobie, Martin, Lundbäck, Thomas, Helleday, Thomas, Rudd, Sean G.

“…SAMHD1 is a dNTP triphosphohydrolase governing nucleotide pool homeostasis and can detoxify chemotherapy metabolites controlling their clinical responses. To…”
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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy by Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio

“…Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used…”
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Correction to New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Bogar, Krisztian, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells by Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

“…With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been…”
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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

“…Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and…”
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Tau-Tubulin Kinase 1 Expression, Phosphorylation and Co-Localization with Phospho-Ser422 Tau in the Alzheimer's Disease Brain by Lund, Harald, Cowburn, Richard F., Gustafsson, Elin, Strömberg, Kia, Svensson, Anne, Dahllund, Leif, Malinowsky, David, Sunnemark, Dan

“…Recent reports have implicated tau‐tubulin kinase 1 (TTBK1) in the pathological phosphorylation of tau that occurs in Alzheimer's disease (AD). The present…”
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Characterization of the effect of a novel γ-secretase modulator on Aβ: a clinically translatable model by Portelius, Erik, Appelkvist, Paulina, Stromberg, Kia, Hoglund, Kina

“…Alzheimer's disease (AD) is a slowly progressing disease and the evaluation of clinical effects of candidate drugs requires large clinical cohorts as well as…”
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MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Puigvert, Jordi Carreras, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jensen, Annika Jenmalm, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin, Berglund, Ulrika Warpman, Helleday, Thomas

“…Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes…”
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Combining an amyloid‐beta (Aβ) cleaving enzyme inhibitor with a γ‐secretase modulator results in an additive reduction of Aβ production by Strömberg, Kia, Eketjäll, Susanna, Georgievska, Biljana, Tunblad, Karin, Eliason, Kristina, Olsson, Fredrik, Radesäter, Ann‐Cathrin, Klintenberg, Rebecka, Arvidsson, Per I, Berg, Stefan, Fälting, Johanna, Cowburn, Richard F, Dabrowski, Michael

“…A major hallmark of Alzheimer's disease (AD) is the deposition of amyloid‐β (Aβ) peptides in amyloid plaques. Aβ peptides are produced by sequential cleavage…”
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Imatinib treatment and Aβ42 in humans by Olsson, Bob, Legros, Laurence, Guilhot, François, Strömberg, Kia, Smith, James, Livesey, Frederick J, Wilson, David H, Zetterberg, Henrik, Blennow, Kaj

“…Abstract Background The first-line treatment in chronic myeloid leukemia (CML), imatinib, has been shown to decrease the production of amyloid-β (Aβ) in vitro…”
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Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production by Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Portelius, Erik, Strömberg, Kia, Borgegård, Tomas, Klintenberg, Rebecka, Juréus, Anders, Blomqvist, Jenny, Blennow, Kaj, Zetterberg, Henrik, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena

“…The γ-secretase complex is an appealing drug target when the therapeutic strategy is to alter amyloid-β peptide (Aβ) aggregation in Alzheimer disease…”
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Tau‐Tubulin Kinase 1 Expression, Phosphorylation and Co‐Localization with Phospho‐ S er422 Tau in the A lzheimer's Disease Brain by Lund, Harald, Cowburn, Richard F., Gustafsson, Elin, Strömberg, Kia, Svensson, Anne, Dahllund, Leif, Malinowsky, David, Sunnemark, Dan

“…Abstract Recent reports have implicated tau‐tubulin kinase 1 ( TTBK 1) in the pathological phosphorylation of tau that occurs in A lzheimer's disease ( AD )…”
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Correction: Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool by Gad, Helge, Koolmeister, Tobias, Jemth, Ann-Sofie, Eshtad, Saeed, Jacques, Sylvain A., Ström, Cecilia E., Svensson, Linda M., Schultz, Niklas, Lundbäck, Thomas, Einarsdottir, Berglind Osk, Saleh, Aljona, Göktürk, Camilla, Baranczewski, Pawel, Svensson, Richard, Berntsson, Ronnie P.-A., Gustafsson, Robert, Strömberg, Kia, Sanjiv, Kumar, Jacques-Cordonnier, Marie-Caroline, Desroses, Matthieu, Gustavsson, Anna-Lena, Olofsson, Roger, Johansson, Fredrik, Homan, Evert J., Loseva, Olga, Bräutigam, Lars, Johansson, Lars, Höglund, Andreas, Hagenkort, Anna, Pham, Therese, Altun, Mikael, Gaugaz, Fabienne Z., Vikingsson, Svante, Evers, Bastiaan, Henriksson, Martin, Vallin, Karl S. A., Wallner, Olov A., Hammarström, Lars G. J., Wiita, Elisee, Almlöf, Ingrid, Kalderén, Christina, Axelsson, Hanna, Djureinovic, Tatjana, Carreras Puigvert, Jordi, Häggblad, Maria, Jeppsson, Fredrik, Martens, Ulf, Lundin, Cecilia, Lundgren, Bo, Granelli, Ingrid, Jenmalm Jensen, Annika, Artursson, Per, Nilsson, Jonas A., Stenmark, Pål, Scobie, Martin

“…Nature 508, 215–221 (2014); doi:10.1038/nature13181 In this Article, the structure of compound TH650 (4) in Fig. 4a was drawn incorrectly; the correct…”
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P2‐317: Impact of different γ‐secretase modulators on Notch‐1 Abeta‐like peptide (Nβ) formation by Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Olsson, Fredrik, Strömberg, Kia, Blomqvist, Jenny, Wollberg, Patrik, Malinowsky, David, Winblad, Bengt, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena

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Impact of different γ-secretase modulators on Notch-1 Abeta-like peptide (Nβ) formation by Wanngren, Johanna, Ottervald, Jan, Parpal, Santiago, Olsson, Fredrik, Strömberg, Kia, Blomqvist, Jenny, Wollberg, Patrik, Malinowsky, David, Winblad, Bengt, Lundkvist, Johan, Rosqvist, Susanne, Karlström, Helena

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[gamma]-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal [gamma]-secretase activity by Strömberg, Kia, Hansson, Emil M, Laudon, Hanna, Bergstedt, Susanne, Näslund, Jan, Lundkvist, Johan, Urban Lendahl

“…The [gamma]-secretase complex processes substrate proteins within membranes and consists of four proteins: presenilin (PS), nicastrin, Aph-1 and Pen-2. PS…”
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Aph‐1 interacts at the cell surface with proteins in the active γ‐secretase complex and membrane‐tethered Notch by Hansson, Emil M., Strömberg, Kia, Bergstedt, Susanne, Yu, Gang, Näslund, Jan, Lundkvist, Johan, Lendahl, Urban

“…The activity of the γ‐secretase complex is critical for the processing of a number of transmembrane proteins, including Notch. Functional γ‐secretase activity…”
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γ‐Secretase complexes containing N‐ and C‐terminal fragments of different presenilin origin retain normal γ‐secretase activity by Strömberg, Kia, Hansson, Emil M., Laudon, Hanna, Bergstedt, Susanne, Näslund, Jan, Lundkvist, Johan, Lendahl, Urban

“…The γ‐secretase complex processes substrate proteins within membranes and consists of four proteins: presenilin (PS), nicastrin, Aph‐1 and Pen‐2. PS harbours…”
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First and Second Generation γ-Secretase Modulators (GSMs) Modulate Amyloid-β (Aβ) Peptide Production through Different Mechanisms by Borgegard, Tomas, Juréus, Anders, Olsson, Fredrik, Rosqvist, Susanne, Sabirsh, Alan, Rotticci, Didier, Paulsen, Kim, Klintenberg, Rebecka, Yan, Hongmei, Waldman, Magnus, Stromberg, Kia, Nord, Johan, Johansson, Jonas, Regner, Anna, Parpal, Santiago, Malinowsky, David, Radesater, Ann-Cathrin, Li, Tingsheng, Singh, Rajeshwar, Eriksson, Hakan, Lundkvist, Johan

“…γ-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-β (Aβ) peptides. The Aβ42…”
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