Monocyte/macrophage initiation of organ-specific autoimmunity: the ultimate ‘bystander’ hypothesis?

It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically. Failure of regulation of pro-inflammatory monocytes/macrophages might then result in autoimmune disease if secondar...

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Bibliographic Details
Published in:	Medical hypotheses Vol. 58; no. 4; pp. 312 - 326
Main Author:	Stoy, N.S.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01-04-2002
Subjects:	Animals Antigen Presentation Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Autoimmune Diseases - immunology Autoimmune Diseases - pathology Autoimmunity - physiology Cell Adhesion Cell Movement Cytokines - physiology Dendritic Cells - immunology Dendritic Cells - pathology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Endothelium, Vascular - physiopathology Genetic Predisposition to Disease Humans Infection - complications Infection - immunology Inflammation - immunology Lymphocyte Subsets - immunology Macrophage Activation Macrophages - pathology Mice Mice, Inbred NOD Models, Animal Models, Immunological Monocytes - pathology Multiple Sclerosis - immunology Multiple Sclerosis - pathology Organ Specificity Rats Rats, Mutant Strains
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Summary:	It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into target organs nonspecifically. Failure of regulation of pro-inflammatory monocytes/macrophages might then result in autoimmune disease if secondary over-expansion of pre-existing autoantigen-specific T cell populations occurs in genetically predisposed individuals.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0306-9877 1532-2777
DOI:	10.1054/mehy.2001.1547