Search Results - "Stoy, N."

Altered kynurenine metabolism correlates with infarct volume in stroke by Darlington, L. G., Mackay, G. M., Forrest, C. M., Stoy, N., George, C., Stone, T. W.

“…Inflammation and oxidative stress are involved in brain damage following stroke, and tryptophan oxidation along the kynurenine pathway contributes to the…”
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Tryptophan metabolism and oxidative stress in patients with Huntington's disease by Stoy, N., Mackay, G. M., Forrest, C. M., Christofides, J., Egerton, M., Stone, T. W., Darlington, L. G.

“…Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and loading were used to investigate…”
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Tryptophan metabolism and oxidative stress in patients with chronic brain injury by Mackay, G. M., Forrest, C. M., Stoy, N., Christofides, J., Egerton, M., Stone, T. W., Darlington, L. G.

“…The kynurenine pathway generates the excitotoxic N‐methyl‐d‐aspartate receptor agonist, quinolinic acid and the glutamate antagonist, kynurenic acid, as well…”
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Tryptophan loading induces oxidative stress by Forrest, C M, Mackay, G M, Stoy, N, Egerton, M, Christofides, J, Stone, T W, Darlington, L G

“…In previous studies tryptophan loads have been administered to human subjects in order to raise central levels of 5-hydroxytryptamine (5HT) and assess the…”
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Tryptophan, adenosine, neurodegeneration and neuroprotection by Stone, T W, Forrest, C M, Mackay, G M, Stoy, N, Darlington, L G

“…This review summarises the potential contributions of two groups of compounds to cerebral dysfunction and damage in metabolic disease. The kynurenines are…”
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Blood 5‐hydroxytryptamine, 5‐hydroxyindoleacetic acid and melatonin levels in patients with either Huntington's disease or chronic brain injury by Christofides, J., Bridel, M., Egerton, M., Mackay, G. M., Forrest, C. M., Stoy, N., Darlington, L. G., Stone, T. W.

“…Following a study of oxidative tryptophan metabolism to kynurenines, we have now analysed the blood of patients with either Huntington's disease or traumatic…”
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Monocyte/macrophage initiation of organ-specific autoimmunity: the ultimate ‘bystander’ hypothesis? by Stoy, N.S.

“…It is postulated that organ-specific autoimmune diseases could be initiated by dysregulated peripherally activated monocytes/macrophages penetrating into…”
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Purine Metabolism and Clinical Status of Patients with Rheumatoid Arthritis Treated with Dipyridamole by Forrest, C. M., Stone, T. W., Mackay, G. M., Oxford, L., Stoy, N., Harman, G., Darlington, L. G.

“…The anti-inflammatory activities of methotrexate and sulphasalazine may be mediated by increases in endogenous adenosine levels. Since the vascular protective…”
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Influence of cholesterol on survival after stroke. Beneficial effects of cholesterol lowering on atherosclerosis may not lessen with age by Stoy, N

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Purine Modulation of Cytokine Release During Diuretic Therapy of Rheumatoid Arthritis by Forrest, C. M., Harman, G., McMillan, R. B., Rana, C., Shaw, S., Stone, T. W., Stoy, N., Darlington, L. G.

“…Since free radicals are implicated in rheumatoid arthritis (RA) and since uric acid is a free radical scavenger, we examined the effects of treating RA…”
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Epilepsy in general practice: patients' psychological symptoms and their perception of stigma by Ridsdale, L, Robins, D, Fitzgerald, A, Jeffery, S, McGee, L

“…null 7 references…”
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Cerebrovascular outcomes of hyperinsulinemia by Stoy, N S

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PRISMS-4: Long-term efficacy of interferon-beta-1a in relapsing MS

“…The PRISMS study demonstrated significant clinical and MRI benefit at 2 years for interferon-beta-1a, 22 and 44 mcg thrice weekly (tiw), compared with placebo…”
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Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis by Ebers, George C

“…Previous trials of interferon β in multiple sclerosis (MS) have shown efficacy, but the degree of clinical benefit remains uncertain, and the optimum dose is…”
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Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis by Ebers, G C, Rice, G, Lesaux, J, Paty, D

“…Previous trials of interferon beta in multiple sclerosis (MS) have shown efficacy, but the degree of clinical benefit remains uncertain, and the optimum dose…”
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Influence of cholesterol on survival after stroke. Beneficial effects of cholesterol lowering on atherosclerosis may not lessen with age by Stoy, N

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Weight loss in Huntington's disease by Stoy, Nicholas, McKay, Eileen

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Macrophage biology and pathobiology in the evolution of immune responses: a functional analysis by Stoy, N

“…A number of general principles of macrophage biology and pathobiology are formulated to define the contribution of macrophages to the kinetics and sequencing…”
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Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment by Forrest, Caroline M, Kennedy, Alan, Stone, Trevor W, Stoy, Nicholas, Darlington, L Gail

“…The kynurenine pathway from tryptophan generates compounds which can act on glutamate receptors in peripheral tissues or modulate free radical activity. We…”
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Modulation of cytokine release by purine receptors in patients with rheumatoid arthritis by FORREST, C. M, HARMAN, G, MCMILLAN, R. B, STOY, N, STONE, T. W, DARLINGTON, L. G

“…Since adenosine receptors are known to modulate the release of some inflammatory mediators in control subjects, we have examined the effects of the mixed A1…”
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