Search Results - "Stowell, Sean R."

The role of galectins in immunity and infection by Liu, Fu-Tong, Stowell, Sean R.

“…The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by a wide variety of cells and bind to galactose-containing glycans…”
Get full text

Protein Glycosylation in Cancer by Stowell, Sean R, Ju, Tongzhong, Cummings, Richard D

“…Neoplastic transformation results in a wide variety of cellular alterations that impact the growth, survival, and general behavior of affected tissue. Although…”
Get full text

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD by Kudelka, Matthew R., Stowell, Sean R., Cummings, Richard D., Neish, Andrew S.

“…Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors have been implicated in IBD pathogenesis, including host genetics,…”
Get full text

Role of Serology in the Coronavirus Disease 2019 Pandemic by Stowell, Sean R, Guarner, Jeannette

Get full text

Biologic roles of the ABH and Lewis histo‐blood group antigens part II: thrombosis, cardiovascular disease and metabolism by Stowell, Sean R., Stowell, Christopher P.

“…The ABH and Lewis antigens were among the first of the human red blood cell polymorphisms to be identified and, in the case of the former, play a dominant role…”
Get full text

Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients by Suthar, Mehul S., Zimmerman, Matthew G., Kauffman, Robert C., Mantus, Grace, Linderman, Susanne L., Hudson, William H., Vanderheiden, Abigail, Nyhoff, Lindsay, Davis, Carl W., Adekunle, Oluwaseyi, Affer, Maurizio, Sherman, Melanie, Reynolds, Stacian, Verkerke, Hans P., Alter, David N., Guarner, Jeannette, Bryksin, Janetta, Horwath, Michael C., Arthur, Connie M., Saakadze, Natia, Smith, Geoffrey H., Edupuganti, Srilatha, Scherer, Erin M., Hellmeister, Kieffer, Cheng, Andrew, Morales, Juliet A., Neish, Andrew S., Stowell, Sean R., Frank, Filipp, Ortlund, Eric, Anderson, Evan J., Menachery, Vineet D., Rouphael, Nadine, Mehta, Aneesh K., Stephens, David S., Ahmed, Rafi, Roback, John D., Wrammert, Jens

“…SARS-CoV-2, the virus responsible for COVID-19, is causing a devastating worldwide pandemic, and there is a pressing need to understand the development,…”
Get full text

Multifaceted role of glycosylation in transfusion medicine, platelets, and red blood cells by Lee‐Sundlov, Melissa M., Stowell, Sean R., Hoffmeister, Karin M.

“…Glycosylation is highly prevalent, and also one of the most complex and varied posttranslational modifications. This large glycan diversity results in a wide…”
Get full text

Refractory thrombotic thrombocytopenic purpura related to checkpoint inhibitor immunotherapy by Lancelot, Moira, Miller, Maureen J., Roback, John, Stowell, Sean R.

“…Background Checkpoint inhibitors enhance T‐lymphocyte–mediated antitumor responses, resulting in increased survival for patients with neoplastic disease…”
Get full text

Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal by Thein, Swee Lay, Pirenne, France, Fasano, Ross M, Habibi, Anoosha, Bartolucci, Pablo, Chonat, Satheesh, Hendrickson, Jeanne E, Stowell, Sean R

Get full text

Contribution of alternative complement pathway to delayed hemolytic transfusion reaction in sickle cell disease by Chonat, Satheesh, Quarmyne, Maa-Ohui, Bennett, Caroline M, Dean, Christina L, Joiner, Clinton H, Fasano, Ross M, Stowell, Sean R

Get full text

Microbial glycan microarrays define key features of host-microbial interactions by Stowell, Sean R, Arthur, Connie M, McBride, Ryan, Berger, Oren, Razi, Nahid, Heimburg-Molinaro, Jamie, Rodrigues, Lilian C, Gourdine, Jean-Philippe, Noll, Alexander J, von Gunten, Stephan, Smith, David F, Knirel, Yuriy A, Paulson, James C, Cummings, Richard D

“…An array of approximately 300 different carbohydrate structures from select gut bacteria was generated and probed with mouse and rabbit IgG samples. The…”
Get full text

Galectin-1, -2, and -3 Exhibit Differential Recognition of Sialylated Glycans and Blood Group Antigens by Stowell, Sean R., Arthur, Connie M., Mehta, Padmaja, Slanina, Kristen A., Blixt, Ola, Leffler, Hakon, Smith, David F., Cummings, Richard D.

“…Human galectins have functionally divergent roles, although most of the members of the galectin family bind weakly to the simple disaccharide lactose…”
Get full text

The SARS-CoV-2 receptor-binding domain preferentially recognizes blood group A by Wu, Shang-Chuen, Arthur, Connie M., Wang, Jianmei, Verkerke, Hans, Josephson, Cassandra D., Kalman, Daniel, Roback, John D., Cummings, Richard D., Stowell, Sean R.

“…•The RBD of SARS-CoV-2 shares sequence similarity with an ancient lectin family known to bind blood group antigens.•SARS-CoV-2 RBD binds the blood group A…”
Get full text

Impact of red blood cell alloimmunization on sickle cell disease mortality: a case series by Nickel, Robert Sheppard, Hendrickson, Jeanne E., Fasano, Ross M., Meyer, Erin K., Winkler, Anne M., Yee, Marianne M., Lane, Peter A., Jones, Yuritzi A., Pashankar, Farzana D., New, Tamara, Josephson, Cassandra D., Stowell, Sean R.

“…BACKGROUND Although red blood cell (RBC) transfusion represents an integral component of sickle cell disease (SCD) care, transfusion support for some patients…”
Get full text

Therapeutic plasma exchange for COVID‐19‐associated hyperviscosity by Truong, Alexander D., Auld, Sara C., Barker, Nicholas A., Friend, Sarah, Wynn, A. Thanushi, Cobb, Jason, Sniecinski, Roman M., Tanksley, Christin‐Lauren, Polly, Derek M., Gaddh, Manila, Connor, Michael, Nakahara, Hirotomo, Sullivan, H. Clifford, Kempton, Christine, Guarner, Jeannette, Duncan, Alexander, Josephson, Cassandra D., Roback, John D., Stowell, Sean R., Maier, Cheryl L.

“…Background Recent data suggests an association between blood hyperviscosity and both propensity for thrombosis and disease severity in patients with COVID‐19…”
Get full text

Transfusion-related acute lung injury: from bedside to bench and back by Shaz, Beth H., Stowell, Sean R., Hillyer, Christopher D.

“…Over the past 60 years, the transfusion medicine community has attained significant knowledge regarding transfusion-related acute lung injury (TRALI) through…”
Get full text

Bridging channel dendritic cells induce immunity to transfused red blood cells by Calabro, Samuele, Gallman, Antonia, Gowthaman, Uthaman, Liu, Dong, Chen, Pei, Liu, Jingchun, Krishnaswamy, Jayendra Kumar, Nascimento, Manuela Sales L, Xu, Lan, Patel, Seema R, Williams, Adam, Tormey, Christopher A, Hod, Eldad A, Spitalnik, Steven L, Zimring, James C, Hendrickson, Jeanne E, Stowell, Sean R, Eisenbarth, Stephanie C

“…Red blood cell (RBC) transfusion is a life-saving therapeutic tool. However, a major complication in transfusion recipients is the generation of antibodies…”
Get full text

Using glycan microarrays to understand immunity by Arthur, Connie M, Cummings, Richard D, Stowell, Sean R

“…•Glycan microarrays can provide significant insight into glycan binding protein specificity.•Different microarrays provide unique methods to study protein…”
Get full text

Eculizumab for complement mediated thrombotic microangiopathy in sickle cell disease by Chonat, Satheesh, Graciaa, Sara, Shin, H Stella, Newton, Joanna G, Quarmyne, Maa-Ohui, Boudreaux, Jeanne, Tang, Amy, Zerra, Patricia E, Rollins, Margo R, Josephson, Cassandra D, Brown, Clark, Joiner, Clinton H, Fasano, Ross M, Stowell, Sean R

Get full text

Full-Length Galectin-3 Is Required for High Affinity Microbial Interactions and Antimicrobial Activity by Wu, Shang-Chuen, Ho, Alex D, Kamili, Nourine A, Wang, Jianmei, Murdock, Kaleb L, Cummings, Richard D, Arthur, Connie M, Stowell, Sean R

“…While adaptive immunity enables the recognition of a wide range of microbial antigens, immunological tolerance limits reactively toward self to reduce…”
Get full text