Search Results - "Stover, R"

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease by Stover, Kurt R., Campbell, Mackenzie A., Van Winssen, Christine M., Brown, Richard E.

“…•3xTg-AD mice had impaired learning and memory in the Barnes maze.•3xTg-AD had enchased performance on the Y-Maze and contextual fear conditioning.•Females…”
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Enfortumab Vedotin Antibody-Drug Conjugate Targeting Nectin-4 Is a Highly Potent Therapeutic Agent in Multiple Preclinical Cancer Models by Challita-Eid, Pia M, Satpayev, Daulet, Yang, Peng, An, Zili, Morrison, Karen, Shostak, Yuriy, Raitano, Arthur, Nadell, Rossana, Liu, Wendy, Lortie, Dawn Ratay, Capo, Linnette, Verlinsky, Alla, Leavitt, Monica, Malik, Faisal, Aviña, Hector, Guevara, Claudia I, Dinh, Nick, Karki, Sher, Anand, Banmeet S, Pereira, Daniel S, Joseph, Ingrid B J, Doñate, Fernando, Morrison, Kendall, Stover, David R

“…The identification of optimal target antigens on tumor cells is central to the advancement of new antibody-based cancer therapies. We performed suppression…”
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Age‐related deterioration of motor function in male and female 5xFAD mice from 3 to 16 months of age by O'Leary, Timothy P., Mantolino, Hector M., Stover, Kurt R., Brown, Richard E.

“…Alzheimer's disease (AD) is a neurodegenerative disorder that leads to age‐related cognitive and sensori‐motor dysfunction. There is an increased understanding…”
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A Review of Antibiotic Use in Pregnancy by Bookstaver, P. Brandon, Bland, Christopher M., Griffin, Brooke, Stover, Kayla R., Eiland, Lea S., McLaughlin, Milena

“…During pregnancy, untreated sexually transmitted or urinary tract infections are associated with significant morbidity, including low birth weight, preterm…”
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Individual differences in proprioception predict the extent of implicit sensorimotor adaptation by Tsay, Jonathan S, Kim, Hyosub E, Parvin, Darius E, Stover, Alissa R, Ivry, Richard B

“…Recent studies have revealed an upper bound in motor adaptation, beyond which other learning systems may be recruited. The factors determining this upper bound…”
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Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates by Zhao, Hui, Atkinson, John, Gulesserian, Sara, Zeng, Zhilan, Nater, Jenny, Ou, Jimmy, Yang, Peng, Morrison, Karen, Coleman, Jeffrey, Malik, Faisal, Challita-Eid, Pia, Karki, Sher, Aviña, Hector, Hubert, René, Capo, Linnette, Snyder, Josh, Moon, Sung-Ju, Luethy, Roland, Mendelsohn, Brian A, Stover, David R, Doñate, Fernando

“…AGS-16C3F is an antibody-drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently…”
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Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma by Fulciniti, Mariateresa, Tassone, Pierfrancesco, Hideshima, Teru, Vallet, Sonia, Nanjappa, Puru, Ettenberg, Seth A., Shen, Zhenxin, Patel, Nipun, Tai, Yu-tzu, Chauhan, Dharminder, Mitsiades, Constantine, Prabhala, Rao, Raje, Noopur, Anderson, Kenneth C., Stover, David R., Munshi, Nikhil C.

“…Decreased activity of osteoblasts (OBs) contributes to osteolytic lesions in multiple myeloma (MM). The production of the soluble Wnt inhibitor Dickkopf-1…”
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Inhibiting Dickkopf‐1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma by Heath, Deborah J, Chantry, Andrew D, Buckle, Clive H, Coulton, Les, Shaughnessy, John D, Evans, Holly R, Snowden, John A, Stover, David R, Vanderkerken, Karin, Croucher, Peter I

“…Multiple myeloma (MM) is associated with the development of osteolytic bone disease, mediated by increased osteoclastic bone resorption and impaired…”
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Urgent need to address infectious diseases due to immunosuppressive therapies by Chastain, Daniel B., Stover, Kayla R.

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Inhibition of Megakaryocyte Differentiation by Antibody-Drug Conjugates (ADCs) is Mediated by Macropinocytosis: Implications for ADC-induced Thrombocytopenia by Zhao, Hui, Gulesserian, Sara, Ganesan, Sathish Kumar, Ou, Jimmy, Morrison, Karen, Zeng, Zhilan, Robles, Veronica, Snyder, Josh, Do, Lisa, Aviña, Hector, Karki, Sher, Stover, David R, Doñate, Fernando

“…Thrombocytopenia is a common adverse event in cancer patients treated with antibody-drug conjugates (ADC), including AGS-16C3F, an ADC targeting ENPP3…”
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Effect of 5′‐adenosine monophosphate‐activated protein kinase agonists on insulin and glucose dynamics in experimentally induced insulin dysregulation in horses by Pinnell, Erin F., Hostnik, Laura D., Watts, Mauria R., Timko, Kathryn J., Thriffiley, Allison A., Stover, Mercedes R., Koenig, Lauren E., Gorman, Olivia M., Toribio, Ramiro E., Burns, Teresa A.

“…Background 5′‐adenosine monophosphate‐activated protein kinase (AMPK) agonists, particularly resveratrol (RES), have not been extensively evaluated for their…”
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Discoidin domain receptor 1 contributes to tumorigenesis through modulation of TGFBI expression by Rudra-Ganguly, Nandini, Lowe, Christine, Mattie, Michael, Chang, Mi Sook, Satpayev, Daulet, Verlinsky, Alla, An, Zili, Hu, Liping, Yang, Peng, Challita-Eid, Pia, Stover, David R, Pereira, Daniel S

“…Discoidin domain receptor 1 (DDR1) is a member of the receptor tyrosine kinase family. The receptor is activated upon binding to its ligand, collagen, and…”
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Adaptive Processes in Thalamus and Cortex Revealed by Silencing of Primary Visual Cortex during Contrast Adaptation by King, Jillian L., Lowe, Matthew P., Stover, Kurt R., Wong, Aimee A., Crowder, Nathan A.

“…Visual adaptation illusions indicate that our perception is influenced not only by the current stimulus but also by what we have seen in the recent past…”
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The Discovery and Preclinical Development of ASG-5ME, an Antibody-Drug Conjugate Targeting SLC44A4-Positive Epithelial Tumors Including Pancreatic and Prostate Cancer by Mattie, Michael, Raitano, Arthur, Morrison, Kendall, Morrison, Karen, An, Zili, Capo, Linnette, Verlinsky, Alla, Leavitt, Monica, Ou, Jimmy, Nadell, Rossana, Aviña, Hector, Guevara, Claudia, Malik, Faisal, Moser, Ruth, Duniho, Steven, Coleman, Jeffrey, Li, Ying, Pereira, Daniel S, Doñate, Fernando, Joseph, Ingrid B J, Challita-Eid, Pia, Benjamin, Dennis, Stover, David R

“…Here, we report the development of an antibody-drug conjugate, ASG-5ME, which targets the solute carrier receptor SLC44A4. SLC44A4 is a member of a family of…”
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High-dose amphotericin: yay or nay? A case series and literature review by Stover, Kayla R, Jordan, Taylor E, Wagner, Jamie L, Barber, Katie E

“…Invasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by…”
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Rethinking urinary antibiotic breakpoints: analysis of urinary antibiotic concentrations to treat multidrug resistant organisms by Chastain, Daniel B, King, S Travis, Stover, Kayla R

“…The present study analyzed whether renally eliminated antibiotics achieve sufficient urinary concentrations based on their pharmacokinetic/pharmacodynamic…”
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Evidence-Based Review of Statin Use in Patients with HIV on Antiretroviral Therapy by Chastain, Daniel B, Stover, Kayla R, Riche, Daniel M

“…Highlights • Cardiovascular disease is up to two times more prevalent in patient with HIV. • Based on pharmacokinetic and clinical data, atorvastatin and…”
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Analysis of the Clinical Impact of the BioFire FilmArray Meningitis Encephalitis Panel on Antimicrobial Use and Duration of Therapy at an Academic Medical Center by Markovich, Kylie, Wingler, Mary Joyce B, Stover, Kayla R, Barber, Katie E, Wagner, Jamie L, Cretella, David A

“…The purpose of this study was to assess the clinical impact of the BioFire FilmArray Meningitis/Encephalitis (ME) panel on antimicrobial use and clinical…”
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Antifungal resistance, combinations and pipeline: oh my by Stover, Kayla R, Hawkins, Brandon K, Keck, J Myles, Barber, Katie E, Cretella, David A

“…Invasive fungal infections are a strong contributor to healthcare costs, morbidity and mortality, especially amongst hospitalized patients. Historically,…”
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AACP Strategic Engagement Committee Report: Report of the 2022–2023 Strategic Engagement Standing Committee by Turner, Kyle, Kawahara, Brian I., Adams, Jennifer L., Akers, Julie M., O’Neal, Katherine, Palombi, Laura C., Stover Hielscher, Kayla R., Shrader, Sarah, Farrell, Dorothy, Collins, Dalita

“…The American Association of Colleges of Pharmacy recognizes strategic engagement as critical to the success of pharmacy education, contributing to the…”
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