Search Results - "Stout, Kristen"

Disruption of mitochondrial complex I induces progressive parkinsonism by González-Rodríguez, Patricia, Zampese, Enrico, Stout, Kristen A., Guzman, Jaime N., Ilijic, Ema, Yang, Ben, Tkatch, Tatiana, Stavarache, Mihaela A., Wokosin, David L., Gao, Lin, Kaplitt, Michael G., López-Barneo, José, Schumacker, Paul T., Surmeier, D. James

“…Loss of functional mitochondrial complex I (MCI) in the dopaminergic neurons of the substantia nigra is a hallmark of Parkinson’s disease 1 . Yet, whether this…”
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The Synaptic Vesicle Glycoprotein 2: Structure, Function, and Disease Relevance by Stout, Kristen A, Dunn, Amy R, Hoffman, Carlie, Miller, Gary W

“…The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A, SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins…”
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Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain by Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tommaso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James

“…Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H 2…”
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Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo by Lohr, Kelly M., Bernstein, Alison I., Stout, Kristen A., Dunn, Amy R., Lazo, Carlos R., Alter, Shawn P., Wang, Minzheng, Li, Yingjie, Fan, Xueliang, Hess, Ellen J., Yi, Hong, Vecchio, Laura M., Goldstein, David S., Guillot, Thomas S., Salahpour, Ali, Miller, Gary W.

“…Disruption of neurotransmitter vesicle dynamics (transport, capacity, release) has been implicated in a variety of neurodegenerative and neuropsychiatric…”
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Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease by Dunn, Amy R., Stout, Kristen A., Ozawa, Minagi, Lohr, Kelly M., Hoffman, Carlie A., Bernstein, Alison I., Li, Yingjie, Wang, Minzheng, Sgobio, Carmelo, Sastry, Namratha, Cai, Huaibin, Caudle, W. Michael, Miller, Gary W.

“…Members of the synaptic vesicle glycoprotein 2 (SV2) family of proteins are involved in synaptic function throughout the brain. The ubiquitously expressed SV2A…”
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The vesicular monoamine transporter 2: An underexplored pharmacological target by Bernstein, Alison I., Stout, Kristen A., Miller, Gary W.

“…•VMAT1 and VMAT2 transport cytosolic monoamines into synaptic vesicles.•Reduced VMAT function has been linked to neurodegenerative conditions.•Modulation of…”
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Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity by Bucher, Meghan L., Dunn, Amy R., Bradner, Joshua M., Egerton, Kristen Stout, Burkett, James P., Johnson, Michelle A., Miller, Gary W.

“…Dopaminergic neurons of the substantia nigra exist in a persistent state of vulnerability resulting from high baseline oxidative stress, high‐energy demand,…”
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Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens by Manvich, Daniel F., Petko, Alyssa K., Branco, Rachel C., Foster, Stephanie L., Porter-Stransky, Kirsten A., Stout, Kristen A., Newman, Amy H., Miller, Gary W., Paladini, Carlos A., Weinshenker, David

“…The dopamine D3 receptor (D3R) has emerged as a promising pharmacotherapeutic target for the treatment of several diseases including schizophrenia, Parkinson’s…”
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Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain by Dunn, Amy R., Hoffman, Carlie A., Stout, Kristen A., Ozawa, Minagi, Dhamsania, Rohan K., Miller, Gary W.

“…•SV2C is expressed in distinct nuclei within the brains of mouse, macaque, and human.•GABAergic and dopaminergic basal ganglia regions show enriched expression…”
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Selective D 2 and D 3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens by Manvich, Daniel F, Petko, Alyssa K, Branco, Rachel C, Foster, Stephanie L, Porter-Stransky, Kirsten A, Stout, Kristen A, Newman, Amy H, Miller, Gary W, Paladini, Carlos A, Weinshenker, David

“…The dopamine D receptor (D R) has emerged as a promising pharmacotherapeutic target for the treatment of several diseases including schizophrenia, Parkinson's…”
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Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism by González-Rodríguez, Patricia, Zampese, Enrico, Stout, Kristen A., Guzman, Jaime N., Ilijic, Ema, Yang, Ben, Tkatch, Tatiana, Stavarache, Mihaela A., Wokosin, David L., Gao, Lin, Kaplitt, Michael G., López-Barneo, José, Schumacker, Paul T., Surmeier, D. James

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Vesicular Monoamine Transporter 2 (VMAT2) Level Regulates MPTP Vulnerability and Clearance of Excess Dopamine in Mouse Striatal Terminals by Lohr, Kelly M, Chen, Merry, Hoffman, Carlie A, McDaniel, Miranda J, Stout, Kristen A, Dunn, Amy R, Wang, Minzheng, Bernstein, Alison I, Miller, Gary W

“…The vesicular monoamine transporter 2 (VMAT2) packages neurotransmitters for release during neurotransmission and sequesters toxicants into vesicles to prevent…”
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Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity by Lohr, Kelly M, Stout, Kristen A, Dunn, Amy R, Wang, Minzheng, Salahpour, Ali, Guillot, Thomas S, Miller, Gary W

“…The psychostimulant methamphetamine (METH) is highly addictive and neurotoxic to dopamine terminals. METH toxicity has been suggested to be due to the release…”
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Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter by Stout, Kristen, Bernaskova, Marketa, Miller, Gary W, Hufner, Antje, Schuehly, Wolfgang

“…In traditional Asian medicinal systems, preparations of the root and stem bark of species are widely used to treat anxiety and other nervous disturbances. The…”
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Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice by Stout, Kristen A, Dunn, Amy R, Lohr, Kelly M, Alter, Shawn P, Cliburn, Rachel A, Guillot, Thomas S, Miller, Gary W

“…Drugs of abuse induce sensitization, which is defined as enhanced response to additional drug following a period of withdrawal. Sensitization occurs in both…”
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Immunochemical localization of vesicular monoamine transporter 2 (VMAT2) in mouse brain by Cliburn, Rachel A., Dunn, Amy R., Stout, Kristen A., Hoffman, Carlie A., Lohr, Kelly M., Bernstein, Alison I., Winokur, Emily J., Burkett, James, Schmitz, Yvonne, Caudle, William M., Miller, Gary W.

“…•We developed a novel antibody for mouse vesicular monoamine transporter 2 (VMAT2).•This VMAT2 antibody is useful in a variety of immunochemical…”
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Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain by Graves, Steven M., Xie, Zhong, Stout, Kristen A., Zampese, Enrico, Burbulla, Lena F., Shih, Jean C., Kondapalli, Jyothisri, Patriarchi, Tommaso, Tian, Lin, Brichta, Lars, Greengard, Paul, Krainc, Dimitri, Schumacker, Paul T., Surmeier, D. James

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo by Kelly M. Lohr, Alison I. Bernstein, Kristen A. Stout, Amy R. Dunn, Carlos R. Lazo, Shawn P. Alter, Minzheng Wang, Yingjie Li, Xueliang Fan, Ellen J. Hess, Hong Yi, Laura M. Vecchio, David S. Goldstein, Thomas S. Guillot, Ali Salahpour, Gary W. Miller

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In Vitro and In Vivo Characterization of the Alkaloid Nuciferine by Farrell, Martilias S, McCorvy, John D, Huang, Xi-Ping, Urban, Daniel J, White, Kate L, Giguere, Patrick M, Doak, Allison K, Bernstein, Alison I, Stout, Kristen A, Park, Su Mi, Rodriguiz, Ramona M, Gray, Bradley W, Hyatt, William S, Norwood, Andrew P, Webster, Kevin A, Gannon, Brenda M, Miller, Gary W, Porter, Joseph H, Shoichet, Brian K, Fantegrossi, William E, Wetsel, William C, Roth, Bryan L

“…The sacred lotus (Nelumbo nucifera) contains many phytochemicals and has a history of human use. To determine which compounds may be responsible for reported…”
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Methamphetamine self-administration causes persistent striatal dopaminergic alterations and mitigates the deficits caused by a subsequent methamphetamine exposure by McFadden, Lisa M, Hadlock, Greg C, Allen, Scott C, Vieira-Brock, Paula L, Stout, Kristen A, Ellis, Jonathan D, Hoonakker, Amanda J, Andrenyak, David M, Nielsen, Shannon M, Wilkins, Diana G, Hanson, Glen R, Fleckenstein, Annette E

“…Preclinical studies have demonstrated that repeated methamphetamine (METH) injections (referred to herein as a "binge" treatment) cause persistent dopaminergic…”
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