Search Results - "Stott, Katharine"

Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations by Stott, Katharine E, Hope, William W

“…Therapeutic drug monitoring (TDM) may be required to achieve optimal clinical outcomes in the setting of significant pharmacokinetic variability, a situation…”
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Challenges for global antibiotic regimen planning and establishing antimicrobial resistance targets: implications for the WHO Essential Medicines List and AWaRe antibiotic book dosing by Reza, Nada, Gerada, Alessandro, Stott, Katharine E, Howard, Alex, Sharland, Mike, Hope, William

“…SUMMARYThe World Health Organisation's 2022 AWaRe Book provides guidance for the use of 39 antibiotics to treat 35 infections in primary healthcare and…”
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Evidence for Expanding the Role of Streptomycin in the Management of Drug-Resistant Mycobacterium tuberculosis by Cohen, Keira A, Stott, Katharine E, Munsamy, Vanisha, Manson, Abigail L, Earl, Ashlee M, Pym, Alexander S

“…In 2019, the WHO tuberculosis (TB) treatment guidelines were updated to recommend only limited use of streptomycin, in favor of newer agents or amikacin as the…”
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Population Pharmacokinetics and Pharmacodynamics of Itraconazole for Disseminated Infection Caused by Talaromyces marneffei by Stott, Katharine E, Le, Thuy, Nguyen, Thu, Whalley, Sarah, Unsworth, Jennifer, Ly, Vo Trieu, Kolamunnage-Dona, Ruwanthi, Hope, William

“…First-line treatment of talaromycosis with amphotericin B deoxycholate (DAmB) is labor-intensive and toxic. Itraconazole is an appealing alternative antifungal…”
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Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis by Giamberardino, Charles D, Tenor, Jennifer L, Toffaletti, Dena L, Palmucci, Julia R, Schell, Wiley, Boua, Jane-Valeriane K, Marius, Choiselle, Stott, Katharine E, Steele, Shelby L, Hope, William, Cilla, Don, Perfect, John R

“…Cryptococcal meningoencephalitis (CM) is a devastating fungal disease with high morbidity and mortality. The current regimen that is standard-of-care involves…”
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Population pharmacokinetics and CSF penetration of flucytosine in adults with HIV-associated cryptococcal meningoencephalitis by Stott, Katharine E, Ahmadu, Ajisa, Kajanga, Cheusisime, Moyo, Melanie, Gondwe, Ebbie, Chimang’anga, Wezzie, Chasweka, Madalitso, Unsworth, Jennifer, Jimenez-Valverde, Ana, Jagota, Bhavana, Shah, Reya V, Lawrence, David S, Lalloo, David G, Harrison, Tom, Jarvis, Joseph N, Hope, William, Mwandumba, Henry C

“…Abstract Background There are limited data describing clinical flucytosine pharmacokinetics (PK). The variability of flucytosine partitioning into the CNS is…”
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Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis by Stott, Katharine E, Beardsley, Justin, Kolamunnage-Dona, Ruwanthi, Castelazo, Anahi Santoyo, Kibengo, Freddie Mukasa, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu’, Cuc, Ngo Thi Kim, Day, Jeremy, Hope, William

“…Robust population pharmacokinetic (PK) data for fluconazole are scarce. The variability of fluconazole penetration into the central nervous system (CNS) is not…”
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Population pharmacokinetics of liposomal amphotericin B in adults with HIV-associated cryptococcal meningoencephalitis by Stott, Katharine E, Moyo, Melanie, Ahmadu, Ajisa, Kajanga, Cheusisime, Gondwe, Ebbie, Chimang’anga, Wezzie, Chasweka, Madalitso, Leeme, Tshepo B, Molefi, Mooketsi, Chofle, Awilly, Bidwell, Gabriella, Changalucha, John, Unsworth, Jenny, Jimenez-Valverde, Ana, Lawrence, David S, Mwandumba, Henry C, Lalloo, David G, Harrison, Thomas S, Jarvis, Joseph N, Hope, William, Märtson, Anne-Grete

“…Abstract Background Single, high-dose liposomal amphotericin B (LAmB; AmBisome, Gilead Sciences) has demonstrated non-inferiority to amphotericin B…”
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Integration of genomic and pharmacokinetic data to predict clinical outcomes in HIV-associated cryptococcal meningitis by Stott, Katharine E, Mohabir, Jason T, Bowers, Katharine, Tenor, Jennifer L, Toffaletti, Dena L, Unsworth, Jennifer, Jimenez-Valverde, Ana, Ahmadu, Ajisa, Moyo, Melanie, Gondwe, Ebbie, Chimang'anga, Wezi, Chasweka, Madalitso, Lawrence, David S, Jarvis, Joseph N, Harrison, Tom, Hope, William, Lalloo, David G, Mwandumba, Henry C, Perfect, John R, Cuomo, Christina A

“…Cryptococcal meningitis causes an estimated 112,000 global deaths per annum. Genomic and phenotypic features of the infecting strain of spp. have been…”
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Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis by Stott, Katharine E, Beardsley, Justin, Whalley, Sarah, Kibengo, Freddie Mukasa, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu', Cuc, Ngo Thi Kim, Kolamunnage-Dona, Ruwanthi, Hope, William, Day, Jeremy

“…There is a limited understanding of the population pharmacokinetics (PK) and pharmacodynamics (PD) of amphotericin B deoxycholate (DAmB) for cryptococcal…”
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AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial by Lawrence, David S, Youssouf, Nabila, Molloy, Síle F, Alanio, Alexandre, Alufandika, Melanie, Boulware, David R, Boyer-Chammard, Timothée, Chen, Tao, Dromer, Francoise, Hlupeni, Admire, Hope, William, Hosseinipour, Mina C, Kanyama, Cecilia, Lortholary, Oliver, Loyse, Angela, Meya, David B, Mosepele, Mosepele, Muzoora, Conrad, Mwandumba, Henry C, Ndhlovu, Chiratidzo E, Niessen, Louis, Schutz, Charlotte, Stott, Katharine E, Wang, Duolao, Lalloo, David G, Meintjes, Graeme, Jaffar, Shabbar, Harrison, Thomas S, Jarvis, Joseph N

“…Cryptococcal meningitis (CM) is a major cause of mortality in HIV programmes in Africa despite increasing access to antiretroviral therapy (ART). Mortality is…”
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Correction for Stott et al., "Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis" by Stott, Katharine E, Beardsley, Justin, Kolamunnage-Dona, Ruwanthi, Castelazo, Anahi Santoyo, Kibengo, Freddie Mukasa, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu', Cuc, Ngo Thi Kim, Day, Jeremy, Hope, William

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Correction for Stott et al., "Population Pharmacokinetic Model and Meta-analysis of Outcomes of Amphotericin B Deoxycholate Use in Adults with Cryptococcal Meningitis" by Stott, Katharine E, Beardsley, Justin, Whalley, Sarah, Mukasa Kibengo, Freddie, Mai, Nguyen Thi Hoang, Tùng, Nguyễn Lê Nhu', Cuc, Ngo Thi Kim, Kolamunnage-Dona, Ruwanthi, Hope, William, Day, Jeremy

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PHARMACOKINETICS OF ORALLY ADMINISTERED VORICONAZOLE IN AFRICAN PENGUINS (SPHENISCUS DEMERSUS) AFTER SINGLE AND MULTIPLE DOSES by Hyatt, Michael W, Wiederhold, Nathan P, Hope, William W, Stott, Katharine E

“…Aspergillosis is a common respiratory fungal disease in African penguins (Spheniscus demersus) under managed care, and treatment failures with itraconazole due…”
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Implementing antiretroviral resistance testing in a primary health care HIV treatment programme in rural KwaZulu-Natal, South Africa: early experiences, achievements and challenges by Lessells, Richard J, Stott, Katharine E, Manasa, Justen, Naidu, Kevindra K, Skingsley, Andrew, Rossouw, Theresa, de Oliveira, Tulio

“…Antiretroviral drug resistance is becoming increasingly common with the expansion of human immunodeficiency virus (HIV) treatment programmes in high prevalence…”
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Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART by Vandormael, Alain M, Boulware, David R, Tanser, Frank C, Bärnighausen, Till W, Stott, Katharine E, de Oliveira, Tulio

“…CD4 count testing is perceived to be an affordable strategy to diagnose treatment failure on first-line antiretroviral therapy. We hypothesize that the…”
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Correction to: AMBIsome Therapy Induction OptimisatioN (AMBITION): High Dose AmBisome for Cryptococcal Meningitis Induction Therapy in sub-Saharan Africa: Study Protocol for a Phase 3 Randomised Controlled Non-Inferiority Trial by Lawrence, David S, Youssouf, Nabila, Molloy, Síle F, Alanio, Alexandre, Alufandika, Melanie, Boulware, David R, Boyer-Chammard, Timothée, Chen, Tao, Dromer, Francoise, Hlupeni, Admire, Hope, William, Hosseinipour, Mina C, Kanyama, Cecilia, Lortholary, Oliver, Loyse, Angela, Meya, David B, Mosepele, Mosepele, Muzoora, Conrad, Mwandumba, Henry C, Ndhlovu, Chiratidzo E, Niessen, Louis, Schutz, Charlotte, Stott, Katharine E, Wang, Duolao, Lalloo, David G, Meintjes, Graeme, Jaffar, Shabbar, Harrison, Thomas S, Jarvis, Joseph N

“…Following publication of the original article [1], we have been notified that one of the author names was listed incorrectly. Both incorrect and correct author…”
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Adequacy of Rifampin Absorption after Jejunostomy Tube Administration by Stott, Katharine E., Singh, Bhagteshwar, Beadsworth, Mike B.J., Vaudrey, Kate, Khoo, Saye H., Davies, Geraint

“…It is not always possible to administer antituberculosis pharmacotherapy orally for reasons that may be a direct consequence of tuberculosis itself. To our…”
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Clostridium difficile : A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa by Keeley, Alexander J, Beeching, Nicholas J, Stott, Katharine E, Roberts, Paul, Watson, Alastair J, Beadsworth, Michael Bj

“…infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is…”
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Combined antiretroviral and antituberculosis drug resistance following incarceration by Stott, Katharine Elizabeth, De Oliveira, Tulio, Lessells, Richard John

“…We describe a case of HIV/tuberculosis (TB) co-infection from KwaZulu-Natal, South Africa, characterised by drug resistance in both pathogens. The development…”
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