Search Results - "Storring, John M."

High transferrin saturation predicts inferior clinical outcomes in patients with myelodysplastic syndromes by Teichman, Jennifer, Geddes, Michelle, Zhu, Nancy, Keating, Mary-Margaret, Sabloff, Mitchell, Christou, Grace, Leber, Brian, Khalaf, Dina, St-Hilaire, Eve, Finn, Nicholas, Shamy, April, Yee, Karen W L, Storring, John M, Nevill, Thomas J, Delage, Robert, Elemary, Mohamed, Banerji, Versha, Houston, Brett, Mozessohn, Lee, Chodirker, Lisa, Zhang, Liying, Siddiqui, Mohammed, Parmentier, Anne, Leitch, Heather A, Buckstein, Rena J

“…Iron overload (IO) reflected by elevated ferritin is associated with increased mortality in myelodysplastic syndromes (MDS), however, ferritin is an imperfect…”
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Ibrutinib plus Bendamustine and Rituximab in Untreated Mantle-Cell Lymphoma by Wang, Michael L., Jurczak, Wojciech, Jerkeman, Mats, Trotman, Judith, Zinzani, Pier L., Belada, David, Boccomini, Carola, Flinn, Ian W., Giri, Pratyush, Goy, Andre, Hamlin, Paul A., Hermine, Olivier, Hernández-Rivas, José-Ángel, Hong, Xiaonan, Kim, Seok Jin, Lewis, David, Mishima, Yuko, Özcan, Muhit, Perini, Guilherme F., Pocock, Christopher, Song, Yuqin, Spurgeon, Stephen E., Storring, John M., Walewski, Jan, Zhu, Jun, Qin, Rui, Henninger, Todd, Deshpande, Sanjay, Howes, Angela, Le Gouill, Steven, Dreyling, Martin

“…A trial involving 523 patients with mantle-cell lymphoma randomly assigned patients to receive bendamustine plus rituximab or these drugs plus ibrutinib. At a…”
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Overall survival in lower IPSS risk MDS by receipt of iron chelation therapy, adjusting for patient‐related factors and measuring from time of first red blood cell transfusion dependence: an MDS‐CAN analysis by Leitch, Heather A., Parmar, Ambica, Wells, Richard A., Chodirker, Lisa, Zhu, Nancy, Nevill, Thomas J., Yee, Karen W. L., Leber, Brian, Keating, Mary‐Margaret, Sabloff, Mitchell, St. Hilaire, Eve, Kumar, Rajat, Delage, Robert, Geddes, Michelle, Storring, John M., Kew, Andrea, Shamy, April, Elemary, Mohamed, Lenis, Martha, Mamedov, Alexandre, Ivo, Jessica, Francis, Janika, Zhang, Liying, Buckstein, Rena

“…Summary Analyses suggest iron overload in red blood cell (RBC) transfusion‐dependent (TD) patients with myleodysplastic syndrome (MDS) portends inferior…”
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Iron overload in myelodysplastic syndromes: Evidence based guidelines from the Canadian consortium on MDS by Leitch, Heather A., Buckstein, Rena, Zhu, Nancy, Nevill, Thomas J., Yee, Karen W.L., Leber, Brian, Keating, Mary-Margaret, St. Hilaire, Eve, Kumar, Rajat, Delage, Robert, Geddes, Michelle, Storring, John M., Shamy, April, Elemary, Mohamed, Wells, Richard A.

“…•In 2008 Canadian guidelines on management of iron overload (IOL) in MDS were published.•Canadian hematologists with an interest in MDS here update the IOL…”
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Treatment of adults with BCR‐ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen by Storring, John M., Minden, Mark D., Kao, Susan, Gupta, Vikas, Schuh, Andre C., Schimmer, Aaron D., Yee, Karen W. L., Kamel‐Reid, Suzanne, Chang, Hong, Lipton, Jeffrey H., Messner, Hans A., Xu, Wei, Brandwein, Joseph M.

“…Summary Between 2000 and 2006, 85 adult BCR‐ABL negative acute lymphoblastic leukaemia (ALL) patients between 18 and 60 years of age were treated using a…”
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ITACA: A new validated international erythropoietic stimulating agent-response score that further refines the predictive power of previous scoring systems by Buckstein, Rena, Balleari, Enrico, Wells, Richard, Santini, Valeria, Sanna, Alessandro, Salvetti, Chiara, Crisà, Elena, Allione, Bernardino, Danise, Paolo, Finelli, Carlo, Clavio, Marino, Poloni, Antonella, Salvi, Flavia, Cilloni, Daniela, Oliva, Esther Natalie, Musto, Pellegrino, Houston, Brett, Zhu, Nancy, Geddes, Michelle, Leitch, Heather, Leber, Brian, Sabloff, Mitchell, Nevill, Thomas J, Yee, Karen W, Storring, John M, Francis, Janika, Maurillo, Luca, Latagliata, Roberto, Spiriti, Maria Antonietta Aloe, Andriani, Alessandro, Piccioni, Anna Lina, Fianchi, Luana, Fenu, Susanna, Gumenyuk, Svitlana, Buccisano, Francesco

“…In 'real-life', the Nordic score guides Erythropoietic stimulating agent (ESA) use in lower-risk myelodysplastic syndrome (MDS) with predicted response rates…”
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The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes: A clinical practice guideline by Leitch, Heather A, Buckstein, Rena, Shamy, April, Storring, John M

“…Abstract Background Myelodysplastic syndromes (MDS) are clonal disorders that result in cytopenias and risk of acute myeloid leukemia. Incidence increases with…”
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A predictive model of response to erythropoietin stimulating agents in myelodysplastic syndrome: from the Canadian MDS patient registry by Houston, Brett L., Jayakar, Jennifer, Wells, Richard A., Lenis, Martha, Zhang, Liying, Zhu, Nancy, Leitch, Heather A., Nevill, Thomas J., Yee, Karen W. L., Leber, Brian, Sabloff, Mitchell, St-Hilaire, Eve, Kumar, Rajat, Geddes, Michelle, Shamy, April, Storring, John M., Keating, Mary-Margaret, Elemary, Mohamed, Delage, Robert, Mamedov, Alex, Buckstein, Rena

“…Prediction of response to erythropoietin stimulating agents (ESAs) in anemic MDS patients is often based on the Nordic score. We wished to validate the Nordic…”
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Outcomes of Allogeneic Hematopoietic Cell Transplantation in Patients with Myelofibrosis with Prior Exposure to Janus Kinase 1/2 Inhibitors by Shanavas, Mohamed, Popat, Uday, Michaelis, Laura C, Fauble, Veena, McLornan, Donal, Klisovic, Rebecca, Mascarenhas, John, Tamari, Roni, Arcasoy, Murat O, Davies, James, Gergis, Usama, Ukaegbu, Oluchi C, Kamble, Rammurti T, Storring, John M, Majhail, Navneet S, Romee, Rizwan, Verstovsek, Srdan, Pagliuca, Antonio, Vasu, Sumithira, Ernst, Brenda, Atenafu, Eshetu G, Hanif, Ahmad, Champlin, Richard, Hari, Paremeswaran, Gupta, Vikas

“…Abstract The impact of Janus kinase (JAK) 1/2 inhibitor therapy before allogeneic hematopoietic cell transplantation (HCT) has not been studied in a large…”
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Heterodimerization of Mineralocorticoid and Glucocorticoid Receptors at a Novel Negative Response Element of the 5-HT1A Receptor Gene by Ou, X M, Storring, J M, Kushwaha, N, Albert, P R

“…Negative regulation of neuronal serotonin (5-HT1A) receptor levels by glucocorticoids in vivo may contribute to depression. Both types I (mineralocorticoid)…”
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Sunitinib malate in patients with intermediate-2 or high-risk myelodysplastic syndrome or chronic myelomonocytic leukemia by Yee, Karen W. L., Storring, John M., Buckstein, Rena, Wells, Richard A., Xenocostas, Anargyros, Kovacs, Michael J., Howson-Jan, Kang, Wang, Eunice S., Battista, Kristina, Wang, Lisa, Oza, Amit M., Ivy, S. Percy, Schuh, Andre C.

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Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus by Brandwein, Joseph M, Geddes, Michelle, Kassis, Jeannine, Kew, Andrea K, Leber, Brian, Nevill, Thomas, Sabloff, Mitchell, Sandhu, Irwindeep, Schuh, Andre C, Storring, John M, Ashkenas, John

“…Patients over age 60 comprise the majority of those diagnosed with acute myeloid leukemia (AML), but treatment approaches in this population are variable, with…”
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Novel Dual Repressor Elements for Neuronal Cell-specific Transcription of the Rat 5-HT1A Receptor Gene by Ou, Xiao-Ming, Jafar-Nejad, Hamed, Storring, John M., Meng, Juan-Hong, Lemonde, Sylvie, Albert, Paul R.

“…The level of expression of the 5-HT1A receptor in the raphe and limbic systems is implicated in the etiology and treatment of major depression and anxiety…”
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The 5-HT1A receptor: Signaling, desensitization, and gene transcription by Albert, Paul R., Lembo, Paola, Storring, John M., Charest, Alain, Saucier, Caroline

“…The hypothesis that antianxiety or antidepressant agents (e.g., 5-HT1A agonists, 5-HT uptake blockers) exert their clinical actions via enhancement of…”
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P244 False positive (self) antibodies in a haploidentical SCT case by Saw, Chee Loong, Storring, John M., Popradi, Gizelle

“…Case History: We evaluated a recipient for potential haploidentical stem cell transplantation for AML. The recipient, a 70year old Asian man had an HLA typing…”
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Transcriptional Mechanisms for Induction of 5-HT1AReceptor mRNA and Protein in Activated B and T Lymphocytes by Abdouh, Mohamed, Storring, John M., Riad, Mustapha, Paquette, Yves, Albert, Paul R., Drobetsky, Elliot, Kouassi, Edouard

“…Serotonin (5-HT) up-regulates B and T lymphocyte proliferation by activating mitogen-induced cell surface 5-HT1A receptors. The mechanism of 5-HT1Areceptor…”
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High Transfusion Dependence and Serum Ferritin but Not Transferrin Saturation Predict Inferior Clinical Outcomes in Patients with MDS by Teichman, Jennifer, Geddes, Michelle, Zhu, Nancy, Keating, Mary-Margaret, Sabloff, Mitchell, Christou, Grace, Leber, Brian, Khalaf, Dina, St-Hilaire, Eve, Finn, Nicholas, Shamy, April, Yee, Karen W.L., Storring, John M., Nevill, Thomas J., Delage, Robert, Elemary, Mohamed, Banerji, Versha, Mozessohn, Lee, Chodirker, Lisa, Zhang, Liying, Siddiqui, Mohammed, Parmentier, Anne, Leitch, Heather A., Buckstein, Rena J.

“…Intro: Iron overload (IO) reflected by elevated serum ferritins is associated with increased mortality in patients with myelodysplastic syndromes (MDS) with a…”
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Fatigue, However Measured, Continues to Refine Prognosis in Higher Risk MDS: An MDS-CAN Study by Amitai, Irina, Geddes, Michelle, Zhu, Nancy, Keating, Mary-Margaret, Sabloff, Mitchell, Christou, Grace, Leber, Brian, Khalaf, Dina, Leitch, Heather A., St-Hilaire, Eve, Finn, Nicholas, Shamy, April, Yee, Karen W.L., Storring, John M., Nevill, Thomas J., Delage, Robert, Elemary, Mohamed, Banerji, Versha, Chodirker, Lisa, Mozessohn, Lee, Parmentier, Anne, Siddiqui, Mohammed, Mamedov, Alexandre, Zhang, Liying, Buckstein, Rena J.

“…Background: The incorporation of patient-reported outcomes with traditional disease risk classification, was found to strengthen survival prediction in…”
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Transcriptional mechanisms for induction of 5-HT1A receptor mRNA and protein in activated B and T lymphocytes by Abdouh, M, Storring, J M, Riad, M, Paquette, Y, Albert, P R, Drobetsky, E, Kouassi, E

“…Serotonin (5-HT) up-regulates B and T lymphocyte proliferation by activating mitogen-induced cell surface 5-HT(1A) receptors. The mechanism of 5-HT(1A)…”
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Quality of Life Scores Improve with Increasing Hemoglobin but Optimal Thresholds Vary According to Transfusion Dependence and Clinical Risk Scores: A Canadian Cross Sectional Study of 689 Patients with 2969 Measurements by Buckstein, Rena, Wells, Richard A., Zhu, Nancy Y, Geddes, Michelle, Sabloff, Mitchell, Leber, Brian, Keating, Mary-Margaret, Storring, John MH, Yee, Karen W.L., Leitch, Heather, St-Hilaire, Eve, Nevill, Thomas J., Shamy, April, Kumar, Rajat, Elemary, Mohamed, Delage, Robert, Lenis, Martha, Mamedov, Alexandre, Ivo, Jessica, Alibhai, Shabbir MH

“…▪ Background: We previously presented that selected quality of life (QOL) domains in MDS patients are impaired compared with age-matched controls and most…”
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