Search Results - "Stork, Philip J.S."

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers by Hu, Jiancheng, Stites, Edward C., Yu, Haiyang, Germino, Elizabeth A., Meharena, Hiruy S., Stork, Philip J.S., Kornev, Alexandr P., Taylor, Susan S., Shaw, Andrey S.

“…Although RAF kinases are critical for controlling cell growth, their mechanism of activation is incompletely understood. Recently, dimerization was shown to be…”
Get full text

PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1 by Schmitt, John M, Stork, Philip J.S

“…In fibroblast cells, cAMP antagonizes growth factor activation of ERKs and cell growth via PKA and the small G protein Rap1. We demonstrate here that PKA's…”
Get full text

ERK5 Activity Is Required for Nerve Growth Factor-induced Neurite Outgrowth and Stabilization of Tyrosine Hydroxylase in PC12 Cells by Obara, Yutaro, Yamauchi, Arata, Takehara, Shin, Nemoto, Wataru, Takahashi, Maho, Stork, Philip J.S., Nakahata, Norimichi

“…Extracellular signal-regulated kinases (ERKs) play important physiological roles in proliferation, differentiation, and gene expression. ERK5 is approximately…”
Get full text

cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway by Vossler, Mark R, Yao, Hong, York, Randall D, Pan, Ming-Gui, Rim, Caroline S, Stork, Philip J.S

“…Cyclic adenosine monophosphate (cAMP) has tissue-specific effects on growth, differentiation, and gene expression. We show here that cAMP can activate the…”
Get full text

Examining the mechanism of Erk nuclear translocation using green fluorescent protein by Horgan, Angela M, Stork, Philip J.S

“…In neuronal cells, the mitogen-activated protein kinase (MAP kinase) cascade is an important mediator of neurotrophin signaling from cell surface receptors to…”
Get full text

Protein Kinase A-dependent Phosphorylation of Rap1 Regulates Its Membrane Localization and Cell Migration by Takahashi, Maho, Dillon, Tara J., Liu, Chang, Kariya, Yumi, Wang, Zhiping, Stork, Philip J.S.

“…The small G protein Rap1 can mediate “inside-out signaling” by recruiting effectors to the plasma membrane that signal to pathways involved in cell adhesion…”
Get full text

Liberated PKA Catalytic Subunits Associate with the Membrane via Myristoylation to Preferentially Phosphorylate Membrane Substrates by Tillo, Shane E., Xiong, Wei-Hong, Takahashi, Maho, Miao, Sheng, Andrade, Adriana L., Fortin, Dale A., Yang, Guang, Qin, Maozhen, Smoody, Barbara F., Stork, Philip J.S., Zhong, Haining

“…Protein kinase A (PKA) has diverse functions in neurons. At rest, the subcellular localization of PKA is controlled by A-kinase anchoring proteins (AKAPs)…”
Get full text

ERK5 induces ankrd1 for catecholamine biosynthesis and homeostasis in adrenal medullary cells by Obara, Yutaro, Nagasawa, Ryusuke, Nemoto, Wataru, Pellegrino, Michael J., Takahashi, Maho, Habecker, Beth A., Stork, Philip J.S., Ichiyanagi, Osamu, Ito, Hiromi, Tomita, Yoshihiko, Ishii, Kuniaki, Nakahata, Norimichi

“…Extracellular signal-regulated kinases (ERKs) play important roles in proliferation, differentiation and gene expression. In our previous study, we…”
Get full text

Analysis of K-Ras Interactions by Biotin Ligase Tagging by Ritchie, Christopher, Mack, Andrew, Harper, Logan, Alfadhli, Ayna, Stork, Philip J S, Nan, Xiaolin, Barklis, Eric

“…Mutations of the human K-Ras 4B (K-Ras) G protein are associated with a significant proportion of all human cancers. Despite this fact, a comprehensive…”
Get full text

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation by Stork, Philip J.S, Schmitt, John M

“…Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms. A…”
Get full text

B-Raf is required for positive selection and survival of DP cells, but not for negative selection of SP cells by Dillon, Tara J, Takahashi, Maho, Li, Yanping, Tavisala, Srilatha, Murray, Susan E, Moran, Amy E, Parker, David C, Stork, Philip J S

“…The duration of signaling through the MAP kinase (or ERK pathway) cascade has been implicated in thymic development, particularly positive and negative…”
Get full text

Neuronal Calcium Activates a Rap1 and B-Raf Signaling Pathway via the Cyclic Adenosine Monophosphate-dependent Protein Kinase by Grewal, Savraj S., Horgan, Angela M., York, Randall D., Withers, Ginger S., Banker, Gary A., Stork, Philip J.S.

“…Activity-dependent regulation of neuronal events such as cell survival and synaptic plasticity is controlled by increases in neuronal calcium levels. These…”
Get full text

ERK Signaling: Duration, Duration, Duration by Stork, Philip J.S.

“…No Abstract Available Key Words: MAP kinase, Growth factor specificity, c-fos, Immediate-early genes, ERK…”
Get full text

The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation by Carey, Kendall D, Watson, Robert T, Pessin, Jeffrey E, Stork, Philip J S

“…Activation of Raf-1 by Ras requires recruitment to the membrane as well as additional phosphorylations, including phosphorylation at serine 338 (Ser-338) and…”
Get full text

cAMP signaling for ERK activation in neuronal cells by Obara, Yutaro, Nakahata, Norimichi, Stork, Philip J S

Get more information

G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells by Pan, Ming Gui, Florio, Tuillio, Philip J. S. Stork

“…The growth-inhibiting peptide hormone somatostatin stimulates phosphotyrosine phosphatase activity in the human pancreatic cell line MIA PaCa-2. This hormonal…”
Get full text

Phosphorylation of Rap1 by cAMP-dependent Protein Kinase (PKA) Creates a Binding Site for KSR to Sustain ERK Activation by cAMP by Takahashi, Maho, Li, Yanping, Dillon, Tara J., Stork, Philip J.S.

“…Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the…”
Get full text

Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP by Li, Yanping, Dillon, Tara J, Takahashi, Maho, Earley, Keith T, Stork, Philip J S

“…Cyclic adenosine monophosphate (cAMP) is an important mediator of hormonal stimulation of cell growth and differentiation through its activation of the…”
Get full text

Local and dynamic regulation of neuronal glycolysis in vivo by Wolfe, Aaron D, Koberstein, John N, Smith, Chadwick B, Stewart, Melissa L, Gonzalez, Ian J, Hammarlund, Marc, Hyman, Anthony A, Stork, Philip J S, Goodman, Richard H, Colón-Ramos, Daniel A

“…Energy metabolism supports neuronal function. While it is well established that changes in energy metabolism underpin brain plasticity and function, less is…”
Get full text

Phosphorylation of the C-Raf N Region Promotes Raf Dimerization by Takahashi, Maho, Li, Yanping, Dillon, Tara J., Kariya, Yumi, Stork, Philip J. S.

“…The activation of Raf kinases by the small GTPase Ras requires two major sets of phosphorylations. One set lies within the activation loop, and the other lies…”
Get full text