Search Results - "Storey, Robert F."
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Updated Expert Consensus Statement on Platelet Function and Genetic Testing for Guiding P2Y12 Receptor Inhibitor Treatment in Percutaneous Coronary Intervention
Published in JACC. Cardiovascular interventions (26-08-2019)“…Dual-antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor is the standard treatment for patients undergoing percutaneous coronary…”
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Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers Colloquium
Published in Nature reviews cardiology (01-07-2022)“…Coronavirus disease 2019 (COVID-19) predisposes patients to thrombotic and thromboembolic events, owing to excessive inflammation, endothelial cell activation…”
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Fibrin clot properties independently predict adverse clinical outcome following acute coronary syndrome: a PLATO substudy
Published in European heart journal (01-04-2018)“…Abstract Aims To determine whether fibrin clot properties are associated with clinical outcomes following acute coronary syndrome (ACS). Methods and results…”
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Expert position paper on air pollution and cardiovascular disease
Published in European heart journal (07-01-2015)Get full text
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Expert position paper on the role of platelet function testing in patients undergoing percutaneous coronary intervention
Published in European heart journal (01-01-2014)Get full text
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Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial
Published in The Lancet (British edition) (16-10-2010)“…Summary Background In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of…”
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Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction
Published in The New England journal of medicine (11-09-2014)“…This study compared administration of the antiplatelet agent ticagrelor in the ambulance with administration in the cath lab in patients with ST-segment…”
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Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis
Published in European heart journal (07-12-2015)Get full text
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Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis
Published in European heart journal (14-05-2018)Get full text
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Dual-pathway inhibition for secondary and tertiary antithrombotic prevention in cardiovascular disease
Published in Nature reviews cardiology (01-04-2020)“…Advances in antiplatelet therapies for patients with cardiovascular disease have improved patient outcomes over time, but the challenge of balancing the risks…”
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P2Y12 inhibitor monotherapy in patients undergoing percutaneous coronary intervention
Published in Nature reviews cardiology (01-12-2022)“…For 20 years, dual antiplatelet therapy (DAPT), consisting of the combination of aspirin and a platelet P2Y 12 receptor inhibitor, has been the gold standard…”
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Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study
Published in The Lancet (British edition) (23-01-2010)“…Summary Background Variation in and irreversibility of platelet inhibition with clopidogrel has led to controversy about its optimum dose and timing of…”
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Treatment inequity in antiplatelet therapy for ischaemic heart disease in patients with advanced chronic kidney disease: releasing the evidence vacuum
Published in Platelets (Edinburgh) (31-12-2023)“…Chronic kidney disease (CKD) is a global health problem and an independent risk factor for cardiovascular morbidity and mortality. Despite evidence-based…”
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Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 Trial
Published in Journal of the American College of Cardiology (15-03-2016)“…Abstract Background The PEGASUS-TIMI 54 (Prevention of Cardiovascular Events in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a…”
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Effect of genetic variations on ticagrelor plasma levels and clinical outcomes
Published in European heart journal (01-08-2015)“…Ticagrelor, a direct-acting P2Y12-receptor antagonist, is rapidly absorbed and partly metabolized to the major metabolite AR-C124910XX (ARC). To identify…”
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Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial
Published in The American heart journal (01-04-2009)“…Background Antiplatelet therapy is essential treatment for acute coronary syndromes (ACS). Current therapies, however, have important limitations affecting…”
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Antiplatelet agents for the treatment and prevention of atherothrombosis
Published in European heart journal (01-12-2011)“…The clinical pharmacology of antiplatelet drugs has been reviewed previously by the European Society of Cardiology (ESC) Task force and by the 8th American…”
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Inhibition of Platelet Aggregation by AZD6140, A Reversible Oral P2Y12 Receptor Antagonist, Compared With Clopidogrel in Patients With Acute Coronary Syndromes
Published in Journal of the American College of Cardiology (06-11-2007)“…Inhibition of Platelet Aggregation by AZD6140, A Reversible Oral P2Y12 Receptor Antagonist, Compared With Clopidogrel in Patients With Acute Coronary Syndromes…”
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Ticagrelor: clinical development and future potential
Published in Reviews in cardiovascular medicine (30-06-2021)“…Platelets participate centrally in atherothrombosis, resulting in vessel occlusion and ischaemia. Consequently, optimisation of antiplatelet regimens has the…”
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Design and rationale for the Prevention of Cardiovascular Events in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin–Thrombolysis in Myocardial Infarction 54 (PEGASUS-TIMI 54) trial
Published in The American heart journal (01-04-2014)“…Background P2Y12 receptor antagonist therapy is recommended in addition to ASA for up to 1 year after acute coronary syndrome to reduce ischemic events. In…”
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