Search Results - "Storer, Richard D"

Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance by Cohen, Samuel M., Storer, Richard D., Criswell, Kay A., Doerrer, Nancy G., Dellarco, Vicki L., Pegg, David G., Wojcinski, Zbigniew W., Malarkey, David E., Jacobs, Abigail C., Klaunig, James E., Swenberg, James A., Cook, Jon C.

“…Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including…”
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Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer by Qin, Chunhua, Wang, Zhibin, Shang, Jin, Bekkari, Kavitha, Liu, Rong, Pacchione, Stephen, McNulty, Kathleen A., Ng, Alan, Barnum, John E., Storer, Richard D.

“…Rodents, mice and rats in particular, are the species of choice for evaluating chemical carcinogenesis. However, different species and strains often respond…”
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An Industry Perspective on the Utility of Short-Term Carcinogenicity Testing in Transgenic Mice in Pharmaceutical Development by Storer, Richard D., Sistare, Frank D., Vijayaraj Reddy, M., Degeorge, Joseph J.

“…International guidelines allow for use of a short-term cancer bioassay (twenty-six weeks) in transgenic mice as a substitute for one of the two required…”
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p53 +/- Hemizygous Knockout Mouse: Overview of Available Data by Storer, Richard D., French, John E., Haseman, Joseph, Hajian, Gerald, Legrand, Edmund K., Long, Gerald G., Mixson, Lori A., Ochoa, Ricardo, Sagartz, John E., Soper, Keith A.

“…The performance of the p53 +/- transgenic (knockout) mouse model was evaluated through review of the data from 31 short-term carcinogenicity studies with 21…”
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An Analysis of Pharmaceutical Experience with Decades of Rat Carcinogenicity Testing: Support for a Proposal to Modify Current Regulatory Guidelines by Sistare, Frank D., Morton, Daniel, Alden, Carl, Christensen, Joel, Keller, Douglas, Jonghe, Sandra De, Storer, Richard D., Reddy, M. Vijayaraj, Kraynak, Andrew, Trela, Bruce, Bienvenu, Jean-Guy, Bjurström, Sivert, Bosmans, Vanessa, Brewster, David, Colman, Karyn, Dominick, Mark, Evans, John, Hailey, James R., Kinter, Lewis, Liu, Matt, Mahrt, Charles, Marien, Dirk, Myer, James, Perry, Richard, Potenta, Daniel, Roth, Arthur, Sherratt, Philip, Singer, Thomas, Slim, Rabih, Soper, Keith, Fransson-Steen, Ronny, Stoltz, James, Turner, Oliver, Turnquist, Susan, van Heerden, Marjolein, Woicke, Jochen, DeGeorge, Joseph J.

“…Data collected from 182 marketed and nonmarketed pharmaceuticals demonstrate that there is little value gained in conducting a rat two-year carcinogenicity…”
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What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments? by Goodman, Jay I, Augustine, Karen A, Cunnningham, Michael L, Dixon, Darlene, Dragan, Yvonne P, Falls, James Greg, Rasoulpour, Reza J, Sills, Robert C, Storer, Richard D, Wolf, Douglas C, Pettit, Syril D

“…The International Life Sciences Institute, Health and Environmental Sciences Institute sponsored a workshop entitled "State of the Science: Evaluating…”
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Validation of a high-throughput in vitro alkaline elution/rat hepatocyte assay for DNA damage by Gealy, Robert, Wright-Bourque, Jennifer L., Kraynak, Andrew R., McKelvey, Troy W., Barnum, John E., Storer, Richard D.

“…In vitro alkaline elution is a sensitive and specific short term assay which measures DNA strand breakage in a mammalian test system (primary rat hepatocytes)…”
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Current status and use of short/medium term models for carcinogenicity testing of pharmaceuticals — scientific perspective by Storer, Richard D

“…Short- and medium-term rodent bioassays have been proposed under ICH guidelines for use in testing for the carcinogenic potential of pharmaceuticals. Further…”
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Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests by Reddy, M. Vijayaraj, Storer, Richard D., Laws, George M., Armstrong, Michael J., Barnum, John E., Gara, Jennifer P., McKnight, Crystal G., Skopek, Thomas R., Sina, Joseph F., DeLuca, John G., Galloway, Sheila M.

“…3‐Methylindole (3MI), melatonin (Mel), serotonin (Ser), and tryptamine (Tryp) were evaluated in vitro for their potential to induce DNA adducts, DNA strand…”
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The Nature of the Heterozygous Trp53 Knockout Model for Identifi cation of Mutagenic Carcinogens by French, John, Storer, Richard D., Donehower, Lawrence A.

“…The heterozygous Trp 53 null allele C57BL/6 (N5) mouse is susceptible to the rapid development of neoplasia by mutagenic carcinogens relative to control…”
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Detection of DNA adducts using a quantitative long PCR technique and the fluorogenic 5' nuclease assay (TaqMan) by Laws, G M, Skopek, T R, Reddy, M V, Storer, R D, Glaab, W E

“…The detection of DNA adducts is an important component in assessing the mutagenic potential of exogenous and endogenous compounds. Here, we report an in vitro…”
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DNA fingerprinting of 7,12-dimethylbenz[a]anthracene-induced and spontaneous CD-1 mouse liver tumors by Ledwith, B J, Storer, R D, Prahalada, S, Manam, S, Leander, K R, van Zwieten, M J, Nichols, W W, Bradley, M O

“…Determining to what degree chemicals and environmental agents contribute to the development of cancer would be materially enhanced by the ability to…”
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An Industry Perspective on the Utility of Short-Term Carcinogen- icity Testing in Transgenic Mice in Pharmaceutical Development by STORER, Richard D, SISTARE, Frank D, VIJAYARAJ REDDY, M, DEGEORGE, Joseph J

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What Do We Need to Know prior to Thinking about Incorporating an Epigenetic Evaluation into Safety Assessments?2 by Goodman, Jay I., Augustine, Karen A., Cunnningham, Michael L., Dixon, Darlene, Dragan, Yvonne P., Falls, James Greg, Rasoulpour, Reza J., Sills, Robert C., Storer, Richard D., Wolf, Douglas C., Pettit, Syril D.

“…The International Life Sciences Institute, Health and Environmental Sciences Institute sponsored a workshop entitled “State of the Science: Evaluating…”
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An investigation of the role of microsomal oxidative metabolism in the in vivo genotoxicity of 1,2-dichloroethane by Storer, R D, Conolly, R B

“…In vitro studies have demonstrated that two different metabolic pathways, glutathione conjugation mediated by the glutathione S-transferases and microsomal…”
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Comparative in vivo genotoxicity and acute hepatotoxicity of three 1,2-dihaloethanes by Storer, R D, Conolly, R B

“…Hepatic DNA damage was demonstrated by alkaline DNA unwinding/hydroxylapatite batch chromatography in male B6C3F1 mice treated with non-necrogenic doses of…”
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Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer: ENDOGENOUS RETROVIRUS AND CANCER SUSCEPTIBILITY by Qin, Chunhua, Wang, Zhibin, Shang, Jin, Bekkari, Kavitha, Liu, Rong, Pacchione, Stephen, McNulty, Kathleen A., Ng, Alan, Barnum, John E., Storer, Richard D.

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In vivo genotoxicity and acute hepatotoxicity of 1,2-dichloroethane in mice: comparison of oral, intraperitoneal, and inhalation routes of exposure by STORER, R. D, JACKSON, N. M, CONOLLY, R. B

“…The in vivo genotoxicity of 1,2-dichloroethane (DCE) was studied in the liver of male C57BL/6 X C3H F1 (hereafter called B6C3F1) mice after single p.o., i.p.,…”
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The mouse lymphoma L5178Y Tk+/- cell line is heterozygous for a codon 170 mutation in the p53 tumor suppressor gene by Storer, R D, Kraynak, A R, McKelvey, T W, Elia, M C, Goodrow, T L, DeLuca, J G

“…The p53 tumor suppressor protein plays an important role in regulating the cellular response to DNA damage, including cell cycle arrest and apoptosis…”
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Malignant transformation of a preneoplastic hamster epidermal cell line by the EJ c-Ha-ras-oncogene by STORER, R. D, STEIN, R. B, SINA, J. F, DELUCA, J. G, ALLEN, H. L, BRADLEY, M. O

“…We have investigated whether the activation of endogenous ras genes is associated with the immortalization or malignant transformation of primary hamster…”
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