Search Results - "Storer, R"

Squaramides: physical properties, synthesis and applications by Storer, R Ian, Aciro, Caroline, Jones, Lyn H

“…Squaramides are remarkable four-membered ring systems derived from squaric acid that are able to form up to four hydrogen bonds. A high affinity for hydrogen…”
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Physiology of Hyperuricemia and Urate-Lowering Treatments by Benn, Caroline L, Dua, Pinky, Gurrell, Rachel, Loudon, Peter, Pike, Andrew, Storer, R Ian, Vangjeli, Ciara

“…Gout is the most common form of inflammatory arthritis and is a multifactorial disease typically characterized by hyperuricemia and monosodium urate crystal…”
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Enantioselective Organocatalytic Reductive Amination by Storer, R. Ian, Carrera, Diane E, Ni, Yike, MacMillan, David W. C

“…The first enantioselective organocatalytic reductive amination reaction has been accomplished. The development of a new chiral phosphoric acid catalyst has…”
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Put a ring on it: application of small aliphatic rings in medicinal chemistry by Bauer, Matthias R, Di Fruscia, Paolo, Lucas, Simon C. C, Michaelides, Iacovos N, Nelson, Jennifer E, Storer, R. Ian, Whitehurst, Benjamin C

“…Aliphatic three- and four-membered rings including cyclopropanes, cyclobutanes, oxetanes, azetidines and bicyclo[1.1.1]pentanes have been increasingly…”
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Direct Enantioselective Brønsted Acid Catalyzed N-Acyliminium Cyclization Cascades of Tryptamines and Ketoacids by Holloway, Chloe A, Muratore, Michael E, Storer, R. lan, Dixon, Darren J

“…A direct enantio- and diastereoselective N-acyliminium cyclization cascade through chiral phosphoric acid catalyzed condensation of tryptamines with γ- and…”
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A semi-quantitative translational pharmacology analysis to understand the relationship between in vitro ENT1 inhibition and the clinical incidence of dyspnoea and bronchospasm by Rosenbrier Ribeiro, Lyn, Ian Storer, R.

“…Adenosine contributes to the pathophysiology of respiratory disease, and adenosine challenge leads to bronchospasm and dyspnoea in patients. The equilibrative…”
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Recent progress in sodium channel modulators for pain by Bagal, Sharan K., Chapman, Mark L., Marron, Brian E., Prime, Rebecca, Storer, R. Ian, Swain, Nigel A.

“…Voltage-gated sodium channels (Navs) are an important family of transmembrane ion channel proteins and Nav drug discovery is an exciting field. Pharmaceutical…”
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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective by Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A

“…Ion channels are membrane proteins expressed in almost all living cells. The sequencing of the human genome has identified more than 400 putative ion channels,…”
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Enantioselective Brønsted Acid-Catalyzed N-Acyliminium Cyclization Cascades by Muratore, Michael E, Holloway, Chloe A, Pilling, Adam W, Storer, R. Ian, Trevitt, Graham, Dixon, Darren J

“…An enantioselective Brønsted acid-catalyzed N-acyliminium cyclization cascade of tryptamines with enol lactones to form architecturally complex heterocycles in…”
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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release by Alexandrou, Aristos J, Brown, Adam R, Chapman, Mark L, Estacion, Mark, Turner, Jamie, Mis, Malgorzata A, Wilbrey, Anna, Payne, Elizabeth C, Gutteridge, Alex, Cox, Peter J, Doyle, Rachel, Printzenhoff, David, Lin, Zhixin, Marron, Brian E, West, Christopher, Swain, Nigel A, Storer, R Ian, Stupple, Paul A, Castle, Neil A, Hounshell, James A, Rivara, Mirko, Randall, Andrew, Dib-Hajj, Sulayman D, Krafte, Douglas, Waxman, Stephen G, Patel, Manoj K, Butt, Richard P, Stevens, Edward B

“…Human genetic studies show that the voltage gated sodium channel 1.7 (Nav1.7) is a key molecular determinant of pain sensation. However, defining the Nav1.7…”
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Design and Evaluation of a Low Hydrogen Bond Donor Count Fragment Screening Set to Aid Hit Generation of PROTACs Intended for Oral Delivery by Whitehurst, Benjamin C., Bauer, Matthias R., Edfeldt, Fredrik, Gunnarsson, Anders, Margreitter, Christian, Rawlins, Philip B., Storer, R. Ian

“…The development of orally bioavailable PROTACs presents a significant challenge due to the inflated physicochemical properties of such heterobifunctional…”
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Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin by Jones, Peter, Storer, R. Ian, Sabnis, Yogesh A, Wakenhut, Florian M, Whitlock, Gavin A, England, Katherine S, Mukaiyama, Takasuke, Dehnhardt, Christoph M, Coe, Jotham W, Kortum, Steve W, Chrencik, Jill E, Brown, David G, Jones, Rhys M, Murphy, John R, Yeoh, Thean, Morgan, Paul, Kilty, Iain

“…By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP…”
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Periaqueductal gray calcitonin gene-related peptide modulates trigeminovascular neurons by Pozo-Rosich, P, Storer, R J, Charbit, A R, Goadsby, P J

“…Calcitonin gene-related peptide (CGRP) receptor antagonism is an approach to migraine therapy. The locus of action of antimigraine treatment is not resolved…”
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Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry by Gomez-Angel, Andres R., Donald, James R., Firth, James D., De Fusco, Claudia, Ian Storer, R., Cox, Daniel J., O’Brien, Peter

“…A multi-gram-scale synthetic route to a novel, bifunctional normorphan 3D building block bearing orthogonally reactive vinyl MIDA boronate and…”
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Author Correction: Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging by van Rhijn, Norman, Zhao, Can, Al-Furaiji, Narjes, Storer, Isabelle S. R., Valero, Clara, Gago, Sara, Chown, Harry, Baldin, Clara, Grant, Rachael-Fortune, Bin Shuraym, Hajer, Ivanova, Lia, Kniemeyer, Olaf, Krüger, Thomas, Bignell, Elaine, Goldman, Gustavo H., Amich, Jorge, Delneri, Daniela, Bowyer, Paul, Brakhage, Axel A., Haas, Hubertus, Bromley, Michael J.

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Hit me with your best shot: Integrated hit discovery for the next generation of drug targets by Ashraf, S. Neha, Blackwell, J. Henry, Holdgate, Geoffrey A., Lucas, Simon C.C., Solovyeva, Alisa, Storer, R. Ian, Whitehurst, Benjamin C.

“…•Identifying good-quality start points is essential for small-molecule drug discovery.•There are an increasing number of challenging targets entering drug…”
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Observations of aerosol-induced convective invigoration in the tropical east Atlantic by Storer, R. L., van den Heever, S. C., L'Ecuyer, T. S.

“…Four years of CloudSat data have been analyzed over a region of the east Atlantic Ocean in order to examine the influence of aerosols on deep convection. The…”
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Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging by van Rhijn, Norman, Zhao, Can, Al-Furaiji, Narjes, Storer, Isabelle S. R., Valero, Clara, Gago, Sara, Chown, Harry, Baldin, Clara, Grant, Rachael-Fortune, Bin Shuraym, Hajer, Ivanova, Lia, Kniemeyer, Olaf, Krüger, Thomas, Bignell, Elaine, Goldman, Gustavo H., Amich, Jorge, Delneri, Daniela, Bowyer, Paul, Brakhage, Axel A., Haas, Hubertus, Bromley, Michael J.

“…More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus . Azole antifungals represent first-line…”
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Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders by Lucas, Simon C. C., Ahmed, Afshan, Ashraf, S. Neha, Argyrou, Argyrides, Bauer, Matthias R., De Donatis, Gian Marco, Demanze, Sylvain, Eisele, Frederik, Fusani, Lucia, Hock, Andreas, Kadamur, Ganesh, Li, Shuyou, Macmillan-Jones, Abigail, Michaelides, Iacovos N., Phillips, Christopher, Rehnström, Marie, Richter, Magdalena, Rodrigo-Brenni, Monica C., Shilliday, Fiona, Wang, Peng, Storer, R. Ian

“…Unlocking novel E3 ligases for use in heterobifunctional PROTAC degraders is of high importance to the pharmaceutical industry. Over-reliance on the current…”
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Voltage gated sodium channels as drug discovery targets by Bagal, Sharan K, Marron, Brian E, Owen, Robert M, Storer, R Ian, Swain, Nigel A

“…Voltage-gated sodium (Na V ) channels are a family of transmembrane ion channel proteins. They function by forming a gated, water-filled pore to help establish…”
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