Search Results - "Storer, Gregory E."

Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467 by Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew

“…ABBV-467 is a highly potent and selective MCL-1 inhibitor that was advanced to a phase I clinical trial for the treatment of multiple myeloma. Due to its large…”
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Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone by Brady, Patrick B., Harper, Kaid C., Sorensen, Bryan K., Greszler, Stephen N., Lai, Chunqiu, Florjancic, Alan S., Zhao, Gang, Shelat, Bhadra H., Storer, Gregory E., Henry, Rodger F., Hansen, T. Matthew

“…Bruton’s tyrosine kinase (BTK) is involved in B-cell receptor signaling and has been clinically validated as a target by small molecule inhibition for the…”
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Scalable Synthesis of ABBV-105 Enabled by Suzuki Coupling with Low Pd Loading, Ru-Catalyzed Asymmetric Hydrogenation, and Acylation Using Impinging Jet by Cardinal-David, Benoit, Shekhar, Shashank, Phillips, Eric M., Swift, Elizabeth C., Kotecki, Brian, Ickes, Andrew R., Storer, Gregory E., Caspi, Daniel D., Verma, Anuj, Moschetta, Eric G., Tao, Daniel, Morrill, Westin H., Bellettini, John R., Nordstrom, Fredrik L., Mattei, Alessandra, Springer, Kirsten, Qiu, Haixiao, Bien, Jeffrey T., Manjrekar, Onkar, Henry, Rodger F., Wallace, Grier A., Schaffter, Lisa, Voight, Eric A.

“…Evolution of a synthetic process to prepare ABBV-105, a Bruton’s tyrosine kinase (BTK)-inhibitor, on multikilogram scale is described. The first-generation…”
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Spiroazetidine–piperidine bromoindane as a key modular template to access a variety of compounds via C–C and C–N bond-forming reactions by Fernando, Dilinie P., Jiao, Wenhua, Polivkova, Jana, Xiao, Jun, Coffey, Steven B., Rose, Colin, Londregan, Allyn, Saenz, James, Beveridge, Ramsay, Zhang, Yingxin, Storer, Gregory E., Vrieze, Derek, Erasga, Noe, Jones, Ryan, Khot, Vishal, Cameron, Kimberly O., McClure, Kim F., Bhattacharya, Samit K., Orr, Suvi T.M.

“…In the context of our ghrelin inverse agonist program, a functionalized bromoindane 3 provided a versatile intermediate for structure–activity relationship…”
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