Search Results - "Stopfer, Lauren E"

Multiplexed relative and absolute quantitative immunopeptidomics reveals MHC I repertoire alterations induced by CDK4/6 inhibition by Stopfer, Lauren E., Mesfin, Joshua M., Joughin, Brian A., Lauffenburger, Douglas A., White, Forest M.

“…Peptides bound to class I major histocompatibility complexes (MHC) play a critical role in immune cell recognition and can trigger an antitumor immune response…”
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High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors by Stopfer, Lauren E, Flower, Cameron T, Gajadhar, Aaron S, Patel, Bhavin, Gallien, Sebastien, Lopez-Ferrer, Daniel, White, Forest M

“…Tyrosine phosphorylation (pTyr) plays a pivotal role in signal transduction and is commonly dysregulated in cancer. As a result, profiling tumor pTyr levels…”
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Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins by Fessenden, Tim B, Stopfer, Lauren E, Chatterjee, Fiona, Zulueta, Julian, Mesfin, Josh, Cordero Dumit, Therese, Reijers, Irene, Hoefsmit, Esmee P, Blank, Christian, White, Forest, Spranger, Stefani

“…BackgroundFor effective tumor elimination, cytotoxic CD8+ T cells must recognize tumor-derived antigens presented on class I major histocompatibility complex…”
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Quantitative Consequences of Protein Carriers in Immunopeptidomics and Tyrosine Phosphorylation MS2 Analyses by Stopfer, Lauren E., Conage-Pough, Jason E., White, Forest M.

“…Utilizing a protein carrier in combination with isobaric labeling to “boost” the signal of other low-level samples in multiplexed analyses has emerged as an…”
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MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas by Stopfer, Lauren E, Rettko, Nicholas J, Leddy, Owen, Mesfin, Joshua M, Brown, Eric, Winski, Shannon, Bryson, Bryan, Wells, James A, White, Forest M

“…Combining multiple therapeutic strategies in NRAS/BRAF mutant melanoma-namely MEK/BRAF kinase inhibitors, immune checkpoint inhibitors (ICIs), and targeted…”
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Deciphering the immunopeptidome in vivo reveals new tumour antigens by Jaeger, Alex M., Stopfer, Lauren E., Ahn, Ryuhjin, Sanders, Emma A., Sandel, Demi A., Freed-Pastor, William A., Rideout, William M., Naranjo, Santiago, Fessenden, Tim, Nguyen, Kim B., Winter, Peter S., Kohn, Ryan E., Westcott, Peter M. K., Schenkel, Jason M., Shanahan, Sean-Luc, Shalek, Alex K., Spranger, Stefani, White, Forest M., Jacks, Tyler

“…Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) molecules 1 – 5 . Current…”
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Absolute quantification of tumor antigens using embedded MHC-I isotopologue calibrants by Stopfer, Lauren E., Gajadhar, Aaron S., Patel, Bhavin, Gallien, Sebastien, Frederick, Dennie T., Boland, Genevieve M., Sullivan, Ryan J., White, Forest M.

“…Absolute quantification measurements (copies per cell) of peptide major histocompatibility complex (pMHC) antigens are necessary to inform targeted…”
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Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration by Prahl, Louis S., Bangasser, Patrick F., Stopfer, Lauren E., Hemmat, Mahya, White, Forest M., Rosenfeld, Steven S., Odde, David J.

“…Microtubule-targeting agents (MTAs) are widely used chemotherapy drugs capable of disrupting microtubule-dependent cellular functions, such as division and…”
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Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma by Kenchappa, Rajappa S., Dovas, Athanassios, Argenziano, Michael G., Meyer, Christian T., Stopfer, Lauren E., Banu, Matei A., Pereira, Brianna, Griffith, Jessica, Mohammad, Afroz, Talele, Surabhi, Haddock, Ashley, Zarco, Natanael, Elmquist, William, White, Forest, Quaranta, Vito, Sims, Peter, Canoll, Peter, Rosenfeld, Steven S.

“…Inhibitors of the mitotic kinesin Kif11 are anti-mitotics that, unlike vinca alkaloids or taxanes, do not disrupt microtubules and are not neurotoxic. However,…”
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A simplified culture system to examine soluble factor interactions between mammalian cells by Carroll, Molly J, Stopfer, Lauren E, Kreeger, Pamela K

“…Interactions between different cell types play critical roles in normal development and disease, but remain challenging to analyse. Here, a co-culture system…”
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Deciphering the immunopeptidome in vivo reveals novel tumor antigens by Jaeger, Alex M., Stopfer, Lauren E., Ahn, Ryuhjin, Sanders, Emma A., Sandel, Demi A., Freed-Pastor, William A., Rideout, William M., Naranjo, Santiago, Fessenden, Tim, Nguyen, Kim B., Winter, Peter S., Kohn, Ryan E., Westcott, Peter M. K., Schenkel, Jason, Shanahan, Sean-Luc, Shalek, Alex K., Spranger, Stefani, White, Forest M., Jacks, Tyler

“…Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I) 1 , 2 , 3 , 4 , 5 . Current…”
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Quantitative Consequences of Protein Carriers in Immunopeptidomics and Tyrosine Phosphorylation MS 2 Analyses by Stopfer, Lauren E, Conage-Pough, Jason E, White, Forest M

“…Utilizing a protein carrier in combination with isobaric labeling to "boost" the signal of other low-level samples in multiplexed analyses has emerged as an…”
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