Search Results - "Stoops, Sydney L"

Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus by Doran, Todd M, Morimoto, Jumpei, Simanski, Scott, Koesema, Eric J, Clark, Lorraine F, Pels, Kevin, Stoops, Sydney L, Pugliese, Alberto, Skyler, Jay S, Kodadek, Thomas

“…A major goal in understanding autoimmune diseases is to define the antigens that elicit a self-destructive immune response, but this is a difficult endeavor…”
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Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets by Brogan, John T, Stoops, Sydney L, Lindsley, Craig W

“…The synthesis of phidianidines A and B, the first 1,2,4-oxadiazole-containing alkaloid, from the marine opisthobranch mollusk Phidiana militaris is reported…”
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Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity by Lewis, Jana A., Scott, Sarah A., Lavieri, Robert, Buck, Jason R., Selvy, Paige E., Stoops, Sydney L., Armstrong, Michelle D., Brown, H. Alex, Lindsley, Craig W.

“…The synthesis and SAR of isoform-selective PLD inhibitors is described. By virtue of the installation of alternative halogenated piperidinyl benzimidazolone…”
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Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape by Mattmann, Margrith E, Stoops, Sydney L, Lindsley, Craig W

“…Akt plays a pivotal role in cell survival and proliferation through a number of downstream effectors; unregulated activation of the PI3K/PTEN/Akt pathway is a…”
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Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition by An, Hanbing, Stoops, Sydney L, Deane, Natasha G, Zhu, Jing, Zi, Jinghuan, Weaver, Connie, Waterson, Alex G, Zijlstra, Andries, Lindsley, Craig W, Beauchamp, Robert Daniel

“…Transcriptional repression of E-cadherin is a hallmark of Epithelial-to-Mesenchymal Transition (EMT) and is associated with cancer cell invasion and…”
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Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs by Aldrich, Leslie N., Stoops, Sydney L., Crews, Brenda C., Marnett, Lawrence J., Lindsley, Craig W.

“…The first total synthesis of tambjamine K and a library of unnatural analogs is reported. Unnatural analogs were shown to be more potent in viability,…”
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Optimization of a small molecule probe that restores e-cadherin expression by Brogan, John T., Stoops, Sydney L., Brady, Suzanne, An, Hanbing, Weaver, Connie, Daniels, J. Scott, Beauchamp, R. Daniel, Lindsley, Craig W., Waterson, Alex G.

“…[Display omitted] E-cadherin is a ubiquitous trans-membrane protein that has important functions in cellular contacts and has been shown to play a role in the…”
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Identification and Optimization of Small Molecules That Restore E-Cadherin Expression and Reduce Invasion in Colorectal Carcinoma Cells by Stoops, Sydney L, Pearson, A. Scott, Weaver, Connie, Waterson, Alex G, Days, Emily, Farmer, Chris, Brady, Suzanne, Weaver, C. David, Beauchamp, R. Daniel, Lindsley, Craig W

“…E-cadherin is a transmembrane protein that maintains intercellular contacts and cell polarity in epithelial tissue. The down-regulation of E-cadherin…”
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Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance by Brogan, John T, Stoops, Sydney L, Crews, Brenda C, Marnett, Lawrence J, Lindsley, Craig W

“…The first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. is reported. The synthesis proceeds in nine steps, eight steps…”
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Abstract B197: Understanding the mechanism of action of small molecules that restore E-cadherin expression by Stoops, Sydney L., Beauchamp, R. Daniel, Lindsley, Craig W.

“…Abstract E-cadherin is a transmembrane protein that maintains intercellular contacts and cellular polarity in epithelial tissues. The down-regulation of…”
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