Effectiveness of a stepped care intervention for anxiety and depression in people with diabetes, asthma or COPD in primary care: A randomized controlled trial

Abstract Background Depression and anxiety are common in people with a chronic somatic disease. Although guidelines recommend stepped care, the effectiveness of this approach has not been evaluated in people with diabetes, asthma, or COPD in primary care. Methods 3559 People were sent screening ques...

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Bibliographic Details
Published in:	Journal of affective disorders Vol. 184; pp. 269 - 276
Main Authors:	Stoop, C.H, Nefs, G, Pommer, A.M, Pop, V.J.M, Pouwer, F
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15-09-2015
Subjects:	Anxiety Anxiety - complications Anxiety - therapy Asthma - complications Asthma - psychology Cognitive Therapy - methods Depression Depression - complications Depression - therapy Depressive Disorder Diabetes Diabetes Complications - psychology Female Humans Lung disease Male Middle Aged Primary Health Care Psychiatry Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - psychology Randomized controlled trial Stepped care Suicidal Ideation general practitioner Lung disease DSM-IV Patient Health Questionnaire DiMaCoDeA GP Depression PHQ-9 Diagnostic and Statistical Manual 4th Edition Randomized controlled trial GAD-7 MINI Disease Management program for Co-morbid Depression and Anxiety NICE Anxiety Diabetes Stepped care Generalized Anxiety Disorder questionnaire Mini-International Neuropsychiatric Interview National Institute for Health and Clinical Excellence COPD chronic obstructive pulmonary disease
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Summary:	Abstract Background Depression and anxiety are common in people with a chronic somatic disease. Although guidelines recommend stepped care, the effectiveness of this approach has not been evaluated in people with diabetes, asthma, or COPD in primary care. Methods 3559 People were sent screening questionnaires (41% response). Of 286 persons with anxiety and/or depression (Generalized Anxiety Disorder questionnaire, GAD-7, cut-off ≥8 and/or Patient Health Questionnaire, PHQ-9, cut-off ≥7), 46 were randomized into the intervention (stepped care and monitoring of symptoms; n =23) or control (usual care) group ( n =23). Main outcomes were symptoms of anxiety and depression after the 12-months intervention and six months post intervention. Analysis of covariance was first adjusted for condition and baseline GAD-7/PHQ-9 scores and additionally for age, sex and education. Results The intervention group had a significantly lower level of anxiety symptoms at the end of the program (GAD-7 6±6 vs. 9±6; Cohen's d =0.61). This effect was still present six months post intervention. The effect on depression was statistically significant in the first model (PHQ-9 6±4 vs. 9±6; p =0.035), but not in the fully adjusted model ( p =0.099), despite a large effect size ( d =0.63). At six months post intervention there was no statistically significant difference in symptoms of depression between the two groups although the difference in symptoms was still clinically significant (Cohen's d =0.61). Limitations Many people were screened, but relatively few participated in the randomized controlled trial. Conclusions Stepped care with monitoring resulted in a lower level of symptoms of anxiety and depression in people with a chronic condition.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0165-0327 1573-2517
DOI:	10.1016/j.jad.2015.05.063