Search Results - "Stonier, Spencer W."

Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design by Khurana, Surender, Ravichandran, Supriya, Hahn, Megan, Coyle, Elizabeth M, Stonier, Spencer W, Zak, Samantha E, Kindrachuk, Jason, Davey, Jr, Richard T, Dye, John M, Chertow, Daniel S

“…Evolution of antibody repertoire against the Ebola virus (EBOV) proteome was characterized in an acutely infected patient receiving supportive care alone to…”
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Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Protects Nonhuman Primates from Intramuscular and Aerosol Challenge with Ebolavirus by Herbert, Andrew S, Kuehne, Ana I, Barth, James F, Ortiz, Ramon A, Nichols, Donald K, Zak, Samantha E, Stonier, Spencer W, Muhammad, Majidat A, Bakken, Russell R, Prugar, Laura I, Olinger, Gene G, Groebner, Jennifer L, Lee, John S, Pratt, William D, Custer, Max, Kamrud, Kurt I, Smith, Jonathan F, Hart, Mary Kate, Dye, John M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcriptional regulation of IL-15 expression during hematopoiesis by Colpitts, Sara L, Stonier, Spencer W, Stoklasek, Thomas A, Root, Sierra H, Aguila, Hector Leonardo, Schluns, Kimberly S, Lefrançois, Leo

“…Dendritic cells (DCs) are the most commonly studied source of the cytokine IL-15. Using an IL-15 reporter transgenic mouse, we have recently shown previously…”
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Extracellular Vesicles and Ebola Virus: A New Mechanism of Immune Evasion by Pleet, Michelle L, DeMarino, Catherine, Stonier, Spencer W, Dye, John M, Jacobson, Steven, Aman, M Javad, Kashanchi, Fatah

“…Ebola virus (EBOV) disease can result in a range of symptoms anywhere from virtually asymptomatic to severe hemorrhagic fever during acute infection…”
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Human Survivors of Disease Outbreaks Caused by Ebola or Marburg Virus Exhibit Cross-Reactive and Long-Lived Antibody Responses by Natesan, Mohan, Jensen, Stig M, Keasey, Sarah L, Kamata, Teddy, Kuehne, Ana I, Stonier, Spencer W, Lutwama, Julius Julian, Lobel, Leslie, Dye, John M, Ulrich, Robert G

“…A detailed understanding of serological immune responses to Ebola and Marburg virus infections will facilitate the development of effective diagnostic methods,…”
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Dendritic Cells Support the In Vivo Development and Maintenance of NK Cells via IL-15 Trans-Presentation by Castillo, Eliseo F, Stonier, Spencer W, Frasca, Loredana, Schluns, Kimberly S

“…IL-15 is a key component that regulates the development and homeostasis of NK cells and is delivered through a mechanism termed trans-presentation. During…”
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Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion by Anthony, Scott M, Rivas, Sarai C, Colpitts, Sara L, Howard, Megan E, Stonier, Spencer W, Schluns, Kimberly S

“…Induction of lymphopenia has been exploited therapeutically to improve immune responses to cancer therapies and vaccinations. Whereas IL-15 has…”
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Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation by Castillo, Eliseo F., Acero, Luis F., Stonier, Spencer W., Zhou, Dapeng, Schluns, Kimberly S.

“…Invariant NKT (iNKT) cells are an innate type of T cells, which respond rapidly on activation. iNKT cells acquire these innate-like abilities during…”
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Dysregulation of TNF-α and IFN-γ expression is a common host immune response in a chronically infected mouse model of melioidosis when comparing multiple human strains of Burkholderia pseudomallei by Amemiya, Kei, Dankmeyer, Jennifer L, Bearss, Jeremy J, Zeng, Xiankun, Stonier, Spencer W, Soffler, Carl, Cote, Christopher K, Welkos, Susan L, Fetterer, David P, Chance, Taylor B, Trevino, Sylvia R, Worsham, Patricia L, Waag, David M

“…Melioidosis is endemic in Southeast Asia and Northern Australia and is caused by the Gram-negative, facultative intracellular pathogen Burkholderia…”
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Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types by Frasca, Loredana, Stonier, Spencer W., Overwijk, Willem W., Schluns, Kimberly S.

“…DC subsets and macrophages differentially mediate memory CD8 T cell maintenance via IL‐15 transpresentation and CD70/CD27 interactions. This study tested the…”
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Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors by Sobarzo, Ariel, Stonier, Spencer W, Herbert, Andrew S, Ochayon, David E, Kuehne, Ana I, Eskira, Yael, Fedida-Metula, Shlomit, Tali, Neta, Lewis, Eli C, Egesa, Moses, Cose, Stephen, Lutwama, Julius Julian, Yavelsky, Victoria, Dye, John M, Lobel, Leslie

“…Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of…”
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Immune memory to Sudan virus: comparison between two separate disease outbreaks by Sobarzo, Ariel, Eskira, Yael, Herbert, Andrew S, Kuehne, Ana I, Stonier, Spencer W, Ochayon, David E, Fedida-Metula, Shlomit, Balinandi, Steven, Kislev, Yaara, Tali, Neta, Lewis, Eli C, Lutwama, Julius Julian, Dye, John M, Yavelsky, Victoria, Lobel, Leslie

“…Recovery from ebolavirus infection in humans is associated with the development of both cell-mediated and humoral immune responses. According to recent…”
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Trans-presentation: A novel mechanism regulating IL-15 delivery and responses by Stonier, Spencer W, Schluns, Kimberly S

“…Abstract Interleukin (IL)-15 is a cytokine that acts on a wide range of cell types but is most crucial for the development, homeostasis, and function of a…”
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Ebola Virus VP40 Modulates Cell Cycle and Biogenesis of Extracellular Vesicles by Pleet, Michelle L, Erickson, James, DeMarino, Catherine, Barclay, Robert A, Cowen, Maria, Lepene, Benjamin, Liang, Janie, Kuhn, Jens H, Prugar, Laura, Stonier, Spencer W, Dye, John M, Zhou, Weidong, Liotta, Lance A, Aman, M Javad, Kashanchi, Fatah

“…Ebola virus (EBOV) mainly targets myeloid cells; however, extensive death of T cells is often observed in lethal infections. We have previously shown that EBOV…”
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A Longitudinal Analysis of Memory Immune Responses in Convalescent Crimean-Congo Hemorrhagic Fever Survivors in Uganda by Cohen, Courtney A, Balinandi, Stephen, Kuehne, Ana I, Rock, Michelle L, Bonagofski, Luke G, Ricks, Keersten M, Davis, Ian, Abelson, Dafna, Stonier, Spencer W, Odongo, Matthew, Bornholdt, Zachary A, Zeitlin, Larry, Moyer, Crystal, Cose, Stephen, Dye, John M, Lutwama, Julius J, Herbert, Andrew S

“…Evaluating the adaptive immune responses to natural infection with Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV) in human survivors is critical to the…”
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Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation by Stonier, Spencer W., Ma, Lisa J., Castillo, Eliseo F., Schluns, Kimberly S.

“…Interleukin-15 (IL-15) is crucial for the development of naive and memory CD8 T cells and is delivered through a mechanism called transpresentation. Previous…”
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Development of an antibody cocktail for treatment of Sudan virus infection by Herbert, Andrew S., Froude, Jeffery W., Ortiz, Ramon A., Kuehne, Ana I., Dorosky, Danielle E., Bakken, Russell R., Zak, Samantha E., Josleyn, Nicole M., Musiychuk, Konstantin, Jones, R. Mark, Green, Brian, Streatfield, Stephen J., Wec, Anna Z., Bohorova, Natasha, Bohorov, Ognian, Kim, Do H., Pauly, Michael H., Velasco, Jesus, Whaley, Kevin J., Stonier, Spencer W., Bornholdt, Zachary A., Chandran, Kartik, Zeitlin, Larry, Sampey, Darryl, Yusibov, Vidadi, Dye, John M.

“…Antibody-based therapies are a promising treatment option for managing ebolavirus infections. Several Ebola virus (EBOV)-specific and, more recently,…”
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Cytokine modulation correlates with severity of monkeypox disease in humans by Johnston, Sara C, Johnson, Joshua C, Stonier, Spencer W, Lin, Kenny L, Kisalu, Neville K, Hensley, Lisa E, Rimoin, Anne W

“…Highlights • Cytokine storm is associated with monkeypox disease in humans. • Circulating GM-CSF, IL-10, and sIL-2R elevations in serious cases suggest…”
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Marburg virus survivor immune responses are Th1 skewed with limited neutralizing antibody responses by Stonier, Spencer W, Herbert, Andrew S, Kuehne, Ana I, Sobarzo, Ariel, Habibulin, Polina, Dahan, Chen V Abramovitch, James, Rebekah M, Egesa, Moses, Cose, Stephen, Lutwama, Julius Julian, Lobel, Leslie, Dye, John M

“…Until recently, immune responses in filovirus survivors remained poorly understood. Early studies revealed IgM and IgG responses to infection with various…”
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Longitudinal peripheral blood transcriptional analysis of a patient with severe Ebola virus disease by Kash, John C, Walters, Kathie-Anne, Kindrachuk, Jason, Baxter, David, Scherler, Kelsey, Janosko, Krisztina B, Adams, Rick D, Herbert, Andrew S, James, Rebekah M, Stonier, Spencer W, Memoli, Matthew J, Dye, John M, Davey, Jr, Richard T, Chertow, Daniel S, Taubenberger, Jeffery K

“…The 2013-2015 outbreak of Ebola virus disease in Guinea, Liberia, and Sierra Leone was unprecedented in the number of documented cases, but there have been few…”
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