Search Results - "Stonehouse, Nicola J."

The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication, but essential for the production of infectious virus by Ward, Joseph C, Lasecka-Dykes, Lidia, Neil, Chris, Adeyemi, Oluwapelumi O, Gold, Sarah, McLean-Pell, Niall, Wright, Caroline, Herod, Morgan R, Kealy, David, Warner, Emma, Jackson, Terry, King, Donald P, Tuthill, Tobias J, Rowlands, David J, Stonehouse, Nicola J

“…Non-coding regions of viral RNA (vRNA) genomes are critically important in the regulation of gene expression. In particular, pseudoknot (PK) structures, which…”
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Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner by FOSTER, Toshana L, GALLAY, Philippe, STONEHOUSE, Nicola J, HARRIS, Mark

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Thrombin cleavage of the hepatitis E virus polyprotein at multiple conserved locations is required for genome replication by Pierce, Danielle M, Buchanan, Frazer J T, Macrae, Fraser L, Mills, Jake T, Cox, Abigail, Abualsaoud, Khadijah M, Ward, Joseph C, Ariëns, Robert A S, Harris, Mark, Stonehouse, Nicola J, Herod, Morgan R

“…The genomes of positive-sense RNA viruses encode polyproteins that are essential for mediating viral replication. These viral polyproteins must undergo…”
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Insights into Polyprotein Processing and RNA-Protein Interactions in Foot-and-Mouth Disease Virus Genome Replication by Pierce, Danielle M, Hayward, Connor, Rowlands, David J, Stonehouse, Nicola J, Herod, Morgan R

“…Foot-and-mouth disease virus (FMDV) is a picornavirus, which infects cloven-hoofed animals to cause foot-and-mouth disease (FMD). The positive-sense RNA genome…”
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Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research by Roberts, Grace C., Zothner, Carsten, Remenyi, Roland, Merits, Andres, Stonehouse, Nicola J., Harris, Mark

“…Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread across the globe and as far north as southern Europe. There is…”
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Positive strand RNA viruses differ in the constraints they place on the folding of their negative strand by Herod, Morgan R, Ward, Joseph C, Tuplin, Andrew, Harris, Mark, Stonehouse, Nicola J, McCormick, Christopher J

“…Genome replication of positive strand RNA viruses requires the production of a complementary negative strand RNA that serves as a template for synthesis of…”
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Dynamics in the murine norovirus capsid revealed by high-resolution cryo-EM by Snowden, Joseph S, Hurdiss, Daniel L, Adeyemi, Oluwapelumi O, Ranson, Neil A, Herod, Morgan R, Stonehouse, Nicola J

“…Icosahedral viral capsids must undergo conformational rearrangements to coordinate essential processes during the viral life cycle. Capturing such…”
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Acute gastroenteritis and the usage pattern of antibiotics and traditional herbal medications for its management in a Nigerian community by Adeyemi, Oluwapelumi Olufemi, Alabi, Ade Stephen, Adeyemi, Oluwasanmi Anuoluwapo, Talabi, Olaoluwa Temitope, Abidakun, Oreoluwa M, Joel, Ireoluwa Yinka, Stonehouse, Nicola J

“…Acute gastroenteritis (AGE) is the highest cause of mortality worldwide in children under the age of 5 years, with the highest mortalities occurring in…”
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Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins by Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C, Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J C, Fry, Elizabeth E, Stuart, David I, Holmes, Kris, Stonehouse, Nicola J, Whelan, Mike, Rosenberg, William, Lomonossoff, George P, Rowlands, David J

“…The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous…”
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All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding by Foster, Toshana L, Belyaeva, Tamara, Stonehouse, Nicola J, Pearson, Arwen R, Harris, Mark

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MicroRNA-106a Inhibits Autophagy Process and Antimicrobial Responses by Targeting ULK1, ATG7, and ATG16L1 During Mycobacterial Infection by Liu, Kunmei, Hong, Dantong, Zhang, Fan, Li, Xin, He, Meng, Han, Xuebo, Zhang, Guolin, Xu, Guangxian, Stonehouse, Nicola J, Jiang, Zhongjia, An, Weijun, Guo, Le

“…Autophagy is a key element of innate immune response against invading pathogens including ( ). The emerging roles of microRNAs in regulating host antimicrobial…”
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Structural insight into Pichia pastoris fatty acid synthase by Snowden, Joseph S., Alzahrani, Jehad, Sherry, Lee, Stacey, Martin, Rowlands, David J., Ranson, Neil A., Stonehouse, Nicola J.

“…Type I fatty acid synthases (FASs) are critical metabolic enzymes which are common targets for bioengineering in the production of biofuels and other products…”
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Capsid protein VP4 of human rhinovirus induces membrane permeability by the formation of a size-selective multimeric pore by Panjwani, Anusha, Strauss, Mike, Gold, Sarah, Wenham, Hannah, Jackson, Terry, Chou, James J, Rowlands, David J, Stonehouse, Nicola J, Hogle, James M, Tuthill, Tobias J

“…Non-enveloped viruses must deliver their viral genome across a cell membrane without the advantage of membrane fusion. The mechanisms used to achieve this…”
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Antimicrobial Peptide LL-37 Facilitates Intracellular Uptake of RNA Aptamer Apt 21-2 Without Inducing an Inflammatory or Interferon Response by Macleod, Tom, Ward, Joseph, Alase, Adewonuola A, Bridgewood, Charlie, Wittmann, Miriam, Stonehouse, Nicola J

“…RNA aptamers are synthetic single stranded RNA oligonucleotides that function analogously to antibodies. Recently, they have shown promise for use in treating…”
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Production and Characterisation of Stabilised PV-3 Virus-like Particles Using Pichia pastoris by Sherry, Lee, Grehan, Keith, Swanson, Jessica J, Bahar, Mohammad W, Porta, Claudine, Fry, Elizabeth E, Stuart, David I, Rowlands, David J, Stonehouse, Nicola J

“…Following the success of global vaccination programmes using the live-attenuated oral and inactivated poliovirus vaccines (OPV and IPV), wild poliovirus (PV)…”
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TMPyP functionalised chitosan membrane for efficient sunlight driven water disinfection by Majiya, Hussaini, Chowdhury, Kaniz F., Stonehouse, Nicola J., Millner, Paul

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Genetic economy in picornaviruses: Foot-and-mouth disease virus replication exploits alternative precursor cleavage pathways by Herod, Morgan R, Gold, Sarah, Lasecka-Dykes, Lidia, Wright, Caroline, Ward, Joseph C, McLean, Thomas C, Forrest, Sophie, Jackson, Terry, Tuthill, Tobias J, Rowlands, David J, Stonehouse, Nicola J

“…The RNA genomes of picornaviruses are translated into single polyproteins which are subsequently cleaved into structural and non-structural protein products…”
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Assembly Pathway of Hepatitis B Core Virus-like Particles from Genetically Fused Dimers by Holmes, Kris, Shepherd, Dale A., Ashcroft, Alison E., Whelan, Mike, Rowlands, David J., Stonehouse, Nicola J.

“…Macromolecular complexes are responsible for many key biological processes. However, in most cases details of the assembly/disassembly of such complexes are…”
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Using Ion Mobility Spectrometry–Mass Spectrometry to Decipher the Conformational and Assembly Characteristics of the Hepatitis B Capsid Protein by Shepherd, Dale A., Holmes, Kris, Rowlands, David J., Stonehouse, Nicola J., Ashcroft, Alison E.

“…The structural and functional analysis of the core protein of hepatitis B virus is important for a full understanding of the viral life cycle and the…”
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The Oxysterol 25-Hydroxycholesterol Inhibits Replication of Murine Norovirus by Shawli, Ghada T, Adeyemi, Oluwapelumi O, Stonehouse, Nicola J, Herod, Morgan R

“…Cholesterol, an essential component of mammalian cells, is also an important factor in the replicative-cycles of several human and animal viruses. The…”
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