Search Results - "Stone, Timothy C."

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal by Rosas, Marcela, Davies, Luke C., Giles, Peter J., Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C., O'Donnell, Valerie B., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow…”
Get full text

Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform by Webber, Jason, Stone, Timothy C., Katilius, Evaldas, Smith, Breanna C., Gordon, Bridget, Mason, Malcolm D., Tabi, Zsuzsanna, Brewis, Ian A., Clayton, Aled

“…We have used a novel affinity-based proteomics technology to examine the protein signature of small secreted extracellular vesicles called exosomes. The…”
Get full text

A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation by Wong, Yen Ting, Tayeb, Michael A, Stone, Timothy C., Lovat, Laurence B., Teschendorff, Andrew E., Iwasiow, Rafal, Craig, Jeffrey M

“…Saliva and buccal samples are popular for epigenome wide association studies (EWAS) due to their ease of collection compared and their ability to sample a…”
Get full text

Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer by Barma, Nafisa, Stone, Timothy C, Carmona Echeverria, Lina Maria, Heavey, Susan

“…Despite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies…”
Get full text

Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease by Lee, Jong-Min, Wheeler, Vanessa C., Chao, Michael J., Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Lucente, Diane, Abu-Elneel, Kawther, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, MacDonald, Marcy E., Gusella, James F., Harold, Denise, Stone, Timothy C., Escott-Price, Valentina, Han, Jun, Vedernikov, Alexey, Holmans, Peter, Jones, Lesley, Kwak, Seung, Mahmoudi, Mithra, Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Dorsey, E. Ray, Shoulson, Ira, Myers, Richard H.

“…As a Mendelian neurodegenerative disorder, the genetic risk of Huntington’s disease (HD) is conferred entirely by an HTT CAG repeat expansion whose length is…”
Get full text

RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation by Miller, James R C, Lo, Kitty K, Andre, Ralph, Hensman Moss, Davina J, Träger, Ulrike, Stone, Timothy C, Jones, Lesley, Holmans, Peter, Plagnol, Vincent, Tabrizi, Sarah J

“…Innate immune activation beyond the central nervous system is emerging as a vital component of the pathogenesis of neurodegeneration. Huntington's disease (HD)…”
Get full text

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis by Poulet, Blandine, Ulici, Veronica, Stone, Timothy C., Pead, Matthew, Gburcik, Valentina, Constantinou, Eleni, Palmer, Donald B., Beier, Frank, Timmons, James A., Pitsillides, Andrew A.

“…Objective Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular…”
Get full text

Face Mask Acceptability for Communal Religious Worship During the COVID-19 Pandemic in the United Kingdom: Results from the CONFESS Study by Ho, Kai Man Alexander, Baggaley, Rebecca F., Stone, Timothy C., Hogan, Áine, Kabir, Yusuf, Johnson, Christopher, Merrifield, Robert, Lovat, Laurence B.

“…The COVID-19 pandemic has led to restrictions such as social distancing and mandatory wearing of face masks. Singing and religious gatherings have been linked…”
Get full text

Impact of the COVID-19 pandemic on communal religious worshippers’ mental health and the benefits of positive religious coping by Baggaley, Rebecca F., Alexander Ho, Kai Man, Maltby, John, Stone, Timothy C., Hoga, Áine, Johnson, Christopher, Merrifield, Robert, Lovat, Laurence B.

“…In the United Kingdom, onsite religious services were halted during COVID-19 lockdowns, which were followed by various levels of restrictions on communal…”
Get full text

Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease by Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., ’t Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter, Tabrizi, Sarah J.

“…There is widespread transcriptional dysregulation in Huntington’s disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem…”
Get full text

Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli by Goh, Shan, Hohmeier, Angela, Stone, Timothy C, Offord, Victoria, Sarabia, Francisco, Garcia-Ruiz, Cristina, Good, Liam

“…Essential bacterial genes located within operons are particularly challenging to study independently because of coordinated gene expression and the…”
Get full text

Novel epigenetic network biomarkers for early detection of esophageal cancer by Maity, Alok K, Stone, Timothy C, Ward, Vanessa, Webster, Amy P, Yang, Zhen, Hogan, Aine, McBain, Hazel, Duku, Margaraet, Ho, Kai Man Alexander, Wolfson, Paul, Graham, David G, Beck, Stephan, Teschendorff, Andrew E, Lovat, Laurence B

“…Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often…”
Get full text

Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence by Bayram-Weston, Zubeyde, Stone, Timothy C, Giles, Peter, Elliston, Linda, Janghra, Nari, Higgs, Gemma V, Holmans, Peter A, Dunnett, Stephen B, Brooks, Simon P, Jones, Lesley

“…The YAC128 model of Huntington's disease (HD) shows substantial deficits in motor, learning and memory tasks and alterations in its transcriptional profile. We…”
Get full text

CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset by Lee, Jong-Min, Correia, Kevin, Loupe, Jacob, Kim, Kyung-Hee, Barker, Douglas, Hong, Eun Pyo, Chao, Michael J., Long, Jeffrey D., Lucente, Diane, Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Abu Elneel, Kawther, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, Wheeler, Vanessa C., MacDonald, Marcy E., Gusella, James F., McAllister, Branduff, Massey, Thomas, Medway, Christopher, Stone, Timothy C., Hall, Lynsey, Jones, Lesley, Holmans, Peter, Kwak, Seung, Ehrhardt, Anka G., Sampaio, Cristina, Ciosi, Marc, Maxwell, Alastair, Chatzi, Afroditi, Monckton, Darren G., Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Dorsey, E. Ray, Shoulson, Ira, Myers, Richard H.

“…Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from the length of huntingtin’s…”
Get full text

B15 Innate transcriptional dysregulation is associated with proinflammatory pathway activation in huntington’s disease myeloid cells by Andre, Ralph, Miller, James RC, Lo, Kitty K, Hensman Moss, Davina J, Träger, Ulrike, Stone, Timothy C, McErlean, Peter, Jones, Lesley, Holmans, Peter, Lavender, Paul, Plagnol, Vincent, Tabrizi, Sarah J

“…BackgroundWhile the central nervous system is considered to be the primary site of Huntington’s disease (HD) pathology, patients exhibit a wide range of…”
Get full text

CLARIFYING THE ADMISSIBILITY OF DWI CHEMICAL TEST REFUSALS IN NEW YORK: THE "TWO-HOUR RULE" DOES NOT APPLY by McCormack, Joseph, Stone, Timothy C

“…Vehicle and Traffic Law (VTL) section 1194 establishes the procedures governing the arrest and testing of an individual suspected of driving while under the…”
Get full text

STATE V. RABB: DOG SNIFFS CLOSE TO HOME by Stone, Timothy C

“…Sensory perception is an inextricable part of Fourth Amendment jurisprudence. As a legal matter, it is undisputed that the "alert" of a trained dog to…”
Get full text