Search Results - "Stone, Timothy"

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal by Rosas, Marcela, Davies, Luke C., Giles, Peter J., Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C., O'Donnell, Valerie B., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow…”
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Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease by Lee, Jong-Min, Wheeler, Vanessa C., Chao, Michael J., Vonsattel, Jean Paul G., Pinto, Ricardo Mouro, Lucente, Diane, Abu-Elneel, Kawther, Ramos, Eliana Marisa, Mysore, Jayalakshmi Srinidhi, Gillis, Tammy, MacDonald, Marcy E., Gusella, James F., Harold, Denise, Stone, Timothy C., Escott-Price, Valentina, Han, Jun, Vedernikov, Alexey, Holmans, Peter, Jones, Lesley, Kwak, Seung, Mahmoudi, Mithra, Orth, Michael, Landwehrmeyer, G. Bernhard, Paulsen, Jane S., Dorsey, E. Ray, Shoulson, Ira, Myers, Richard H.

“…As a Mendelian neurodegenerative disorder, the genetic risk of Huntington’s disease (HD) is conferred entirely by an HTT CAG repeat expansion whose length is…”
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Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform by Webber, Jason, Stone, Timothy C., Katilius, Evaldas, Smith, Breanna C., Gordon, Bridget, Mason, Malcolm D., Tabi, Zsuzsanna, Brewis, Ian A., Clayton, Aled

“…We have used a novel affinity-based proteomics technology to examine the protein signature of small secreted extracellular vesicles called exosomes. The…”
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Sources of Tobacco Smoke Exposure and Their Associations With Serum Cotinine Levels Among US Children and Adolescents by Merianos, Ashley L, Stone, Timothy M, Jandarov, Roman A, Mahabee-Gittens, E Melinda, Choi, Kelvin

“…Abstract Introduction We assessed tobacco smoke exposure (TSE) levels based on private and public locations of TSE according to race and ethnicity among US…”
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A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation by Wong, Yen Ting, Tayeb, Michael A, Stone, Timothy C., Lovat, Laurence B., Teschendorff, Andrew E., Iwasiow, Rafal, Craig, Jeffrey M

“…Saliva and buccal samples are popular for epigenome wide association studies (EWAS) due to their ease of collection compared and their ability to sample a…”
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Cerebrospinal fluid extracellular vesicle enrichment for protein biomarker discovery in neurological disease; multiple sclerosis by Welton, Joanne L., Loveless, Samantha, Stone, Timothy, von Ruhland, Chris, Robertson, Neil P., Clayton, Aled

“…The discovery of disease biomarkers, along with the use of "liquid biopsies" as a minimally invasive source of biomarkers, continues to be of great interest…”
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Tobacco Smoke Exposure and Sleep Duration among U.S. Adolescents by Merianos, Ashley L., Stone, Timothy M., Mahabee-Gittens, E. Melinda, Jandarov, Roman A., Choi, Kelvin

“…Tobacco smoke exposure (TSE) and poor sleep are public health problems with their own set of consequences. This study assessed whether TSE was associated with…”
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Distinguishing Exposure to Secondhand and Thirdhand Tobacco Smoke among U.S. Children Using Machine Learning: NHANES 2013–2016 by Merianos, Ashley L., Mahabee-Gittens, E. Melinda, Stone, Timothy M., Jandarov, Roman A., Wang, Lanqing, Bhandari, Deepak, Blount, Benjamin C., Matt, Georg E.

“…While the thirdhand smoke (THS) residue from tobacco smoke has been recognized as a distinct public health hazard, there are currently no gold standard…”
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RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation by Miller, James R C, Lo, Kitty K, Andre, Ralph, Hensman Moss, Davina J, Träger, Ulrike, Stone, Timothy C, Jones, Lesley, Holmans, Peter, Plagnol, Vincent, Tabrizi, Sarah J

“…Innate immune activation beyond the central nervous system is emerging as a vital component of the pathogenesis of neurodegeneration. Huntington's disease (HD)…”
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Contamination of surfaces in children’s homes with nicotine and the potent carcinogenic tobacco-specific nitrosamine NNK by Merianos, Ashley L., Matt, Georg E., Stone, Timothy M., Jandarov, Roman A., Hoh, Eunha, Dodder, Nathan G., Quintana, Penelope J. E., Lopez-Galvez, Nicolas, Stone, Lara, Mahabee-Gittens, E. Melinda

“…Background Tobacco smoke exposure (TSE) through secondhand and thirdhand smoke is a modifiable risk factor that contributes to childhood morbidity. Limited…”
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Mapping Historical Archaeology and Industrial Heritage: The Historical Spatial Data Infrastructure by Trepal, Dan, Lafreniere, Don, Stone, Timothy

“…While a vibrant and growing research literature exists on the value of GIS to archaeology in general, the application of geospatial digital data to the…”
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Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition by Crist, McKenzie, Yaniv, Benyamin, Palackdharry, Sarah, Lehn, Maria A, Medvedovic, Mario, Stone, Timothy, Gulati, Shuchi, Karivedu, Vidhya, Borchers, Michael, Fuhrman, Bethany, Crago, Audrey, Curry, Joseph, Martinez-Outschoorn, Ubaldo, Takiar, Vinita, Wise-Draper, Trisha M

“…BackgroundMetformin slows tumor growth and progression in vitro, and in combination with chemoradiotherapy, resulted in high overall survival in patients with…”
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Exploring the Value of BRD9 as a Biomarker, Therapeutic Target and Co-Target in Prostate Cancer by Barma, Nafisa, Stone, Timothy C, Carmona Echeverria, Lina Maria, Heavey, Susan

“…Despite recent advances in advanced prostate cancer treatments, clinical biomarkers or treatments for men with such cancers are imperfect. Targeted therapies…”
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Impact of the COVID-19 pandemic on communal religious worshippers’ mental health and the benefits of positive religious coping by Baggaley, Rebecca F., Alexander Ho, Kai Man, Maltby, John, Stone, Timothy C., Hoga, Áine, Johnson, Christopher, Merrifield, Robert, Lovat, Laurence B.

“…In the United Kingdom, onsite religious services were halted during COVID-19 lockdowns, which were followed by various levels of restrictions on communal…”
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Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis by Poulet, Blandine, Ulici, Veronica, Stone, Timothy C., Pead, Matthew, Gburcik, Valentina, Constantinou, Eleni, Palmer, Donald B., Beier, Frank, Timmons, James A., Pitsillides, Andrew A.

“…Objective Chronological age is a powerful epidemiologic risk factor for osteoarthritis (OA), a multifactorial disease that is characterized by articular…”
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Face Mask Acceptability for Communal Religious Worship During the COVID-19 Pandemic in the United Kingdom: Results from the CONFESS Study by Ho, Kai Man Alexander, Baggaley, Rebecca F., Stone, Timothy C., Hogan, Áine, Kabir, Yusuf, Johnson, Christopher, Merrifield, Robert, Lovat, Laurence B.

“…The COVID-19 pandemic has led to restrictions such as social distancing and mandatory wearing of face masks. Singing and religious gatherings have been linked…”
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Huntington’s disease blood and brain show a common gene expression pattern and share an immune signature with Alzheimer’s disease by Hensman Moss, Davina J., Flower, Michael D., Lo, Kitty K., Miller, James R. C., van Ommen, Gert-Jan B., ’t Hoen, Peter A. C., Stone, Timothy C., Guinee, Amelia, Langbehn, Douglas R., Jones, Lesley, Plagnol, Vincent, van Roon-Mom, Willeke M. C., Holmans, Peter, Tabrizi, Sarah J.

“…There is widespread transcriptional dysregulation in Huntington’s disease (HD) brain, but analysis is inevitably limited by advanced disease and postmortem…”
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Silencing of Essential Genes within a Highly Coordinated Operon in Escherichia coli by Goh, Shan, Hohmeier, Angela, Stone, Timothy C, Offord, Victoria, Sarabia, Francisco, Garcia-Ruiz, Cristina, Good, Liam

“…Essential bacterial genes located within operons are particularly challenging to study independently because of coordinated gene expression and the…”
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Novel epigenetic network biomarkers for early detection of esophageal cancer by Maity, Alok K, Stone, Timothy C, Ward, Vanessa, Webster, Amy P, Yang, Zhen, Hogan, Aine, McBain, Hazel, Duku, Margaraet, Ho, Kai Man Alexander, Wolfson, Paul, Graham, David G, Beck, Stephan, Teschendorff, Andrew E, Lovat, Laurence B

“…Early detection of esophageal cancer is critical to improve survival. Whilst studies have identified biomarkers, their interpretation and validity is often…”
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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma by Lewis, Clayton S., Karve, Aniruddha, Matiash, Kateryna, Stone, Timothy, Li, Jingxing, Wang, Jordon K., Versteeg, Henri H., Aronow, Bruce J., Ahmad, Syed A., Desai, Pankaj B., Bogdanov, Vladimir Y.

“…In 2021, pancreatic ductal adenocarcinoma (PDAC) is the 3 rd leading cause of cancer deaths in the United States. This is largely due to a lack of symptoms and…”
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