Search Results - "Stone, David J."

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease by Zhang, Bin, Gaiteri, Chris, Bodea, Liviu-Gabriel, Wang, Zhi, McElwee, Joshua, Podtelezhnikov, Alexei A., Zhang, Chunsheng, Xie, Tao, Tran, Linh, Dobrin, Radu, Fluder, Eugene, Clurman, Bruce, Melquist, Stacey, Narayanan, Manikandan, Suver, Christine, Shah, Hardik, Mahajan, Milind, Gillis, Tammy, Mysore, Jayalakshmi, MacDonald, Marcy E., Lamb, John R., Bennett, David A., Molony, Cliona, Stone, David J., Gudnason, Vilmundur, Myers, Amanda J., Schadt, Eric E., Neumann, Harald, Zhu, Jun, Emilsson, Valur

“…The genetics of complex disease produce alterations in the molecular interactions of cellular pathways whose collective effect may become clear through the…”
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The MIMIC Code Repository: enabling reproducibility in critical care research by Johnson, Alistair EW, Stone, David J, Celi, Leo A, Pollard, Tom J

“…Abstract Objective Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In…”
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A Comparative Analysis of Sepsis Identification Methods in an Electronic Database by Johnson, Alistair E. W., Aboab, Jerome, Raffa, Jesse D., Pollard, Tom J., Deliberato, Rodrigo O., Celi, Leo A., Stone, David J.

“…OBJECTIVES:To evaluate the relative validity of criteria for the identification of sepsis in an ICU database. DESIGN:Retrospective cohort study of adult ICU…”
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Transthoracic echocardiography and mortality in sepsis: analysis of the MIMIC-III database by Feng, Mengling, McSparron, Jakob I., Kien, Dang Trung, Stone, David J., Roberts, David H., Schwartzstein, Richard M., Vieillard-Baron, Antoine, Celi, Leo Anthony

“…Purpose While the use of transthoracic echocardiography (TTE) in the ICU is rapidly expanding, the contribution of TTE to altering patient outcomes among ICU…”
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Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases by Narayanan, Manikandan, Huynh, Jimmy L, Wang, Kai, Yang, Xia, Yoo, Seungyeul, McElwee, Joshua, Zhang, Bin, Zhang, Chunsheng, Lamb, John R, Xie, Tao, Suver, Christine, Molony, Cliona, Melquist, Stacey, Johnson, Andrew D, Fan, Guoping, Stone, David J, Schadt, Eric E, Casaccia, Patrizia, Emilsson, Valur, Zhu, Jun

“…Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in…”
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Transcriptional Architecture of the Primate Neocortex by Bernard, Amy, Lubbers, Laura S., Tanis, Keith Q., Luo, Rui, Podtelezhnikov, Alexei A., Finney, Eva M., McWhorter, Mollie M.E., Serikawa, Kyle, Lemon, Tracy, Morgan, Rebecca, Copeland, Catherine, Smith, Kimberly, Cullen, Vivian, Davis-Turak, Jeremy, Lee, Chang-Kyu, Sunkin, Susan M., Loboda, Andrey P., Levine, David M., Stone, David J., Hawrylycz, Michael J., Roberts, Christopher J., Jones, Allan R., Geschwind, Daniel H., Lein, Ed S.

“…Genome-wide transcriptional profiling was used to characterize the molecular underpinnings of neocortical organization in rhesus macaque, including cortical…”
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Withholding or withdrawing invasive interventions may not accelerate time to death among dying ICU patients by Ramazzotti, Daniele, Clardy, Peter, Celi, Leo Anthony, Stone, David J, Rudin, Robert S

“…Critically ill patients may die despite invasive intervention. In this study, we examine trends in the application of two such treatments over a decade,…”
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A Comparative Study on the Lysosomal Cation Channel TMEM175 Using Automated Whole-Cell Patch-Clamp, Lysosomal Patch-Clamp, and Solid Supported Membrane-Based Electrophysiology: Functional Characterization and High-Throughput Screening Assay Development by Bazzone, Andre, Barthmes, Maria, George, Cecilia, Brinkwirth, Nina, Zerlotti, Rocco, Prinz, Valentin, Cole, Kim, Friis, Søren, Dickson, Alexander, Rice, Simon, Lim, Jongwon, Fern Toh, May, Mohammadi, Milad, Pau, Davide, Stone, David J., Renger, John J., Fertig, Niels

“…The lysosomal cation channel TMEM175 is a Parkinson’s disease-related protein and a promising drug target. Unlike whole-cell automated patch-clamp (APC),…”
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Machine Learning for Pulmonary and Critical Care Medicine: A Narrative Review by Mlodzinski, Eric, Stone, David J., Celi, Leo A.

“…Machine learning (ML) is a discipline of computer science in which statistical methods are applied to data in order to classify, predict, or optimize, based on…”
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Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies by Geiger, Joshua T, Ding, Jinhui, Crain, Barbara, Pletnikova, Olga, Letson, Christopher, Dawson, Ted M, Rosenthal, Liana S, Pantelyat, Alexander, Gibbs, J. Raphael, Albert, Marilyn S, Hernandez, Dena G, Hillis, Argye E, Stone, David J, Singleton, Andrew B, Hardy, John A, Troncoso, Juan C, Scholz, Sonja W

“…Abstract Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer ' s disease. Although an increasing number of…”
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Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis by Stopa, Edward G, Tanis, Keith Q, Miller, Miles C, Nikonova, Elena V, Podtelezhnikov, Alexei A, Finney, Eva M, Stone, David J, Camargo, Luiz M, Parker, Lisan, Verma, Ajay, Baird, Andrew, Donahue, John E, Torabi, Tara, Eliceiri, Brian P, Silverberg, Gerald D, Johanson, Conrad E

“…In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression…”
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One-year mortality after recovery from critical illness: A retrospective cohort study by Lokhandwala, Sharukh, McCague, Ned, Chahin, Abdullah, Escobar, Braiam, Feng, Mengling, Ghassemi, Mohammad M, Stone, David J, Celi, Leo Anthony

“…Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding…”
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Crowdsourcing knowledge discovery and innovations in medicine by Celi, Leo Anthony, Ippolito, Andrea, Montgomery, Robert A, Moses, Christopher, Stone, David J

“…Clinicians face difficult treatment decisions in contexts that are not well addressed by available evidence as formulated based on research. The digitization…”
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The clinical artificial intelligence department: a prerequisite for success by Cosgriff, Christopher V., Stone, David J., Weissman, Gary, Pirracchio, Romain, Celi, Leo Anthony

“…[...]there is a stark contrast between the lack of concrete penetration of AI in medical practice, and the expectations set by the presence of AI in our daily…”
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Making big data useful for health care: a summary of the inaugural mit critical data conference by Badawi, Omar, Brennan, Thomas, Celi, Leo Anthony, Feng, Mengling, Ghassemi, Marzyeh, Ippolito, Andrea, Johnson, Alistair, Mark, Roger G, Mayaud, Louis, Moody, George, Moses, Christopher, Naumann, Tristan, Pimentel, Marco, Pollard, Tom J, Santos, Mauro, Stone, David J, Zimolzak, Andrew

“…With growing concerns that big data will only augment the problem of unreliable research, the Laboratory of Computational Physiology at the Massachusetts…”
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Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging by Podtelezhnikov, Alexei A, Tanis, Keith Q, Nebozhyn, Michael, Ray, William J, Stone, David J, Loboda, Andrey P

“…Alzheimer's disease (AD) is a complex neurodegenerative disorder that diverges from the process of normal brain aging by unknown mechanisms. We analyzed the…”
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Critical Care, Critical Data by Cosgriff, Christopher V, Celi, Leo Anthony, Stone, David J

“…As big data, machine learning, and artificial intelligence continue to penetrate into and transform many facets of our lives, we are witnessing the emergence…”
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Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers by Shen, Li, Thompson, Paul M., Potkin, Steven G., Bertram, Lars, Farrer, Lindsay A., Foroud, Tatiana M., Green, Robert C., Hu, Xiaolan, Huentelman, Matthew J., Kim, Sungeun, Kauwe, John S. K., Li, Qingqin, Liu, Enchi, Macciardi, Fabio, Moore, Jason H., Munsie, Leanne, Nho, Kwangsik, Ramanan, Vijay K., Risacher, Shannon L., Stone, David J., Swaminathan, Shanker, Toga, Arthur W., Weiner, Michael W., Saykin, Andrew J.

“…The Genetics Core of the Alzheimer’s Disease Neuroimaging Initiative (ADNI), formally established in 2009, aims to provide resources and facilitate research…”
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Grape seed extract and dried macroalgae, Ulva lactuca Linnaeus, improve survival of greenlip abalone, Haliotis laevigata Donovan, at high water temperature by Lange, Brett, Currie, Krishna-Lee, Howarth, Gordon S., Stone, David A.J.

“…Summer mortality (SM) in greenlip abalone (Haliotis laevigata Donovan) heavily affects productivity of land-based abalone farms in Southern Australia. It has…”
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Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing by Camargo, Luiz Miguel, Zhang, Xiaohua Douglas, Loerch, Patrick, Caceres, Ramon Miguel, Marine, Shane D, Uva, Paolo, Ferrer, Marc, de Rinaldis, Emanuele, Stone, David J, Majercak, John, Ray, William J, Yi-An, Chen, Shearman, Mark S, Mizuguchi, Kenji

“…The progressive aggregation of Amyloid-β (Aβ) in the brain is a major trait of Alzheimer's Disease (AD). Aβ is produced as a result of proteolytic processing…”
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