Search Results - "Stomper, Julia"

Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies by Stomper, Julia, Rotondo, John Charles, Greve, Gabriele, Lübbert, Michael

“…Aberrant DNA methylation plays a pivotal role in tumor development and progression. DNA hypomethylating agents (HMA) constitute a class of drugs which are able…”
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Fetal hemoglobin induction during decitabine treatment of elderly patients with high-risk myelodysplastic syndrome or acute myeloid leukemia: a potential dynamic biomarker of outcome by Stomper, Julia, Ihorst, Gabriele, Suciu, Stefan, Sander, Philipp N, Becker, Heiko, Wijermans, Pierre W, Plass, Christoph, Weichenhan, Dieter, Bissé, Emmanuel, Claus, Rainer, Lübbert, Michael

“…Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a…”
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The antileukemic activity of decitabine upon PML/RARA-negative AML blasts is supported by all-trans retinoic acid: in vitro and in vivo evidence for cooperation by Meier, Ruth, Greve, Gabriele, Zimmer, Dennis, Bresser, Helena, Berberich, Bettina, Langova, Ralitsa, Stomper, Julia, Rubarth, Anne, Feuerbach, Lars, Lipka, Daniel B., Hey, Joschka, Grüning, Björn, Brors, Benedikt, Duyster, Justus, Plass, Christoph, Becker, Heiko, Lübbert, Michael

“…The prognosis of AML patients with adverse genetics, such as a complex, monosomal karyotype and TP53 lesions, is still dismal even with standard chemotherapy…”
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Landscape of chromosome number changes in prostate cancer progression by Braun, Martin, Stomper, Julia, Kirsten, Robert, Adler, David, Vogel, Wenzel, Böhm, Diana, Wernert, Nicolas, Kristiansen, Glen, Perner, Sven

“…Purpose Both genetic instability resulting in aneuploidy and increased proliferative activity are common features of tumor development and progression…”
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Can we predict responsiveness to hypomethylating agents in AML? by Stomper, Julia, Lübbert, Michael

“…DNA-hypomethylating agents (HMAs) were developed as nonintensive treatment alternatives to standard chemotherapy in older, unfit patients with acute myeloid…”
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Integrative Study of EZH2 Mutational Status, Copy Number, Protein Expression and H3K27 Trimethylation in AML/MDS Patients by Stomper, Julia, Meier, Ruth, Ma, Tobias, Pfeifer, Dietmar, Schmitt-Graeff, Annette, Lübbert, Michael

“…Introduction Enhancer of Zeste Homolog 2 (EZH2), the catalytic domain of Polycomb Repressive Complex 2 (PRC2), mediates the repressive mark of trimethylation…”
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Decitabine-Induced Early Platelet Response, a Predictor of Favorable Outcome during Hypomethylating Treatment of MDS, Is Associated with In Vivo Megakaryocytic Differentiation by Stomper, Julia, May, Annette M., Joeckel, Tina E., Bronsert, Peter, Werner, Martin, Lübbert, Michael

“…Introduction Despite broad use of hypomethylating agents (HMAs) in MDS/AML treatment, the number of established outcome predictors is still very limited…”
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Decitabine Induces Gene Derepression on Monosomic Chromosomes: In Vitro and In Vivo Effects in Adverse-Risk Cytogenetics AML by Greve, Gabriele, Schüler, Julia, Grüning, Björn A, Berberich, Bettina, Stomper, Julia, Zimmer, Dennis, Gutenkunst, Lea, Bönisch, Ulrike, Meier, Ruth, Blagitko-Dorfs, Nadja, Grishina, Olga, Pfeifer, Dietmar, Weichenhan, Dieter, Plass, Christoph, Lübbert, Michael

“…Hypomethylating agents (HMA) have become the backbone of nonintensive acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) treatment, also by virtue of…”
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Genetic and Epigenetic Changes at Secondary Resistance after Continued Treatment in the Randomized Phase II Study of All-Trans Retinoic Acid (ATRA) and/or Valproic Acid (VPA) Added to Decitabine (DAC) in Newly Diagnosed Elderly AML Patients (DECIDER Trial) by Hund, Inga, Hess, Maria, Stomper, Julia, Greve, Gabriele, Mitschke, Jan, Niemöller, Christoph, Ma, Tobias, Uhl, David, Thol, Felicitas R., Heuser, Michael, Bug, Gesine, Crysandt, Martina, Mueller, Lutz Peter, Neubauer, Andreas, Duyster, Justus, Dohner, Hartmut, Boerries, Melanie, Becker, Heiko, Luebbert, Michael

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Distinct bone marrow morphologic features discriminate myelodysplastic syndromes patients with and without an early platelet response to decitabine by May, Annette M., Stomper, Julia, Joeckel, Tina E., Bronsert, Peter, Wijermans, Pierre W., Werner, Martin, Lübbert, Michael

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Fetal Hemoglobin (HbF) Induction during Initial Decitabine (DAC) Treatment of Elderly High-Risk MDS and AML Patients: A Potential Dynamic Biomarker for Outcome by Stomper, Julia, Ihorst, Gabriele, Suciu, Stefan, Sander, Philipp Nikolaus, Becker, Heiko, Wijermans, P.W., Bissé, Emmanuel, Claus, Rainer, Lübbert, Michael

“…Introduction: The full effects of DNA-hypomethylating agent (HMA) treatment, the present standard for many MDS and AML patients, often become apparent only…”
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Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients by Stomper, Julia, Meier, Ruth, Ma, Tobias, Pfeifer, Dietmar, Ihorst, Gabriele, Blagitko-Dorfs, Nadja, Greve, Gabriele, Zimmer, Dennis, Platzbecker, Uwe, Hagemeijer, Anne, Schmitt-Graeff, Ingrid, Lübbert, Michael

“…Mutations in the EZH2 gene are recurrently found in patients with myeloid neoplasms and are associated with a poor prognosis. We aimed to characterize genetic…”
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Correction to: Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients by Stomper, Julia, Meier, Ruth, Ma, Tobias, Pfeifer, Dietmar, Ihorst, Gabriele, Blagitko-Dorfs, Nadja, Greve, Gabriele, Zimmer, Dennis, Platzbecker, Uwe, Hagemeijer, Anne, Schmitt-Graeff, Ingrid, Lübbert, Michael

“…An amendment to this paper has been published and can be accessed via the original article…”
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Deferasirox-induced robust and dose-dependent reversal of anemia in a patient with variants in the TRIB2 and ABCB6 genes by Stomper, Julia, Richter-Pechanska, Paulina, Pfeifer, Dietmar, Andolfo, Immacolata, Iolascon, Achille, Muckenthaler, Martina U., Lübbert, Michael

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Improved Method of Detecting the ERG Gene Rearrangement in Prostate Cancer Using Combined Dual-Color Chromogenic and Silver In Situ Hybridization by Braun, Martin, Stomper, Julia, Boehm, Diana, Vogel, Wenzel, Scheble, Veit J, Wernert, Nicolas, Shaikhibrahim, Zaki, Fend, Falko, Kristiansen, Glen, Perner, Sven

“…The recently detected TMPRSS2-ERG fusion gene was revealed as a recurrent and prevalent prostate cancer (PCa)-specific event, potentially qualifying it for…”
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