Search Results - "Stommel, Jayne M."

Pancreatic cancers require autophagy for tumor growth by Yang, Shenghong, Wang, Xiaoxu, Contino, Gianmarco, Liesa, Marc, Sahin, Ergun, Ying, Haoqiang, Bause, Alexandra, Li, Yinghua, Stommel, Jayne M, Dell'antonio, Giacomo, Mautner, Josef, Tonon, Giovanni, Haigis, Marcia, Shirihai, Orian S, Doglioni, Claudio, Bardeesy, Nabeel, Kimmelman, Alec C

“…Macroautophagy (autophagy) is a regulated catabolic pathway to degrade cellular organelles and macromolecules. The role of autophagy in cancer is complex and…”
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Cholesterol Metabolism: A Potential Therapeutic Target in Glioblastoma by Ahmad, Fahim, Sun, Qian, Patel, Deven, Stommel, Jayne M

“…Glioblastoma is a highly lethal adult brain tumor with no effective treatments. In this review, we discuss the potential to target cholesterol metabolism as a…”
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Malignant astrocytic glioma: genetics, biology, and paths to treatment by Furnari, Frank B, Fenton, Tim, Bachoo, Robert M, Mukasa, Akitake, Stommel, Jayne M, Stegh, Alexander, Hahn, William C, Ligon, Keith L, Louis, David N, Brennan, Cameron, Chin, Lynda, DePinho, Ronald A, Cavenee, Webster K

“…Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression…”
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Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies by Stommel, Jayne M, Kimmelman, Alec C, Ying, Haoqiang, Nabioullin, Roustem, Ponugoti, Aditya H, Wiedemeyer, Ruprecht, Stegh, Alexander H, Bradner, James E, Ligon, Keith L, Brennan, Cameron, Chin, Lynda, DePinho, Ronald A

“…Targeted therapies that inhibit receptor tyrosine kinases (RTKs) and the downstream phosphatidylinositol 3-kinase (PI3K) signaling pathway have shown promising…”
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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation by DePinho, Ronald A, Zheng, Hongwu, Ying, Haoqiang, Yan, Haiyan, Kimmelman, Alec C, Hiller, David J, Chen, An-Jou, Perry, Samuel R, Tonon, Giovanni, Chu, Gerald C, Ding, Zhihu, Stommel, Jayne M, Dunn, Katherine L, Wiedemeyer, Ruprecht, You, Mingjian J, Brennan, Cameron, Wang, Y. Alan, Ligon, Keith L, Wong, Wing H, Chin, Lynda

“…Glioblastoma (GBM) is a highly lethal brain tumour presenting as one of two subtypes with distinct clinical histories and molecular profiles. The primary GBM…”
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Hdmx Modulates the Outcome of P53 Activation in Human Tumor Cells by Wade, Mark, Wong, Ee Tsin, Tang, Mengjia, Stommel, Jayne M., Wahl, Geoffrey M.

“…Tumors that express wild-type P53 provide a target for therapies designed to reactivate P53 function. This is supported by the potent activation of P53 in…”
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Mig-6 controls EGFR trafficking and suppresses gliomagenesis by Ying, Haoqiang, Zheng, Hongwu, Scott, Kenneth, Wiedemeyer, Ruprecht, Yan, Haiyan, Lim, Carol, Huang, Joseph, Dhakal, Sabin, Ivanova, Elena, Xiao, Yonghong, Zhang, Hailei, Hu, Jian, Stommel, Jayne M, Lee, Michelle A, Chen, An-Jou, Paik, Ji-Hye, Segatto, Oreste, Brennan, Cameron, Elferink, Lisa A, Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A

“…Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that is driven by aberrant signaling of growth factor receptors, particularly…”
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A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation by Stommel, Jayne M., Wahl, Geoffrey M.

“…The p53 tumor suppressor is a transcription factor that is activated by diverse genotoxic and cytotoxic stresses. Upon activation, p53 prevents the…”
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CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level by Yuen, Garmen, Khan, Fehad J, Gao, Shaojian, Stommel, Jayne M, Batchelor, Eric, Wu, Xiaolin, Luo, Ji

“…CRISPR/Cas9 is a powerful gene editing tool for gene knockout studies and functional genomic screens. Successful implementation of CRISPR often requires Cas9…”
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p53 regulation by post-translational modification and nuclear retention in response to diverse stresses: p53 by JIMENEZ, G. S, KHAN, S. H, STOMMEL, J. M, WAHL, G. M

“…p53 activation by diverse stresses involves post-translational modifications that alter its structure and result in its nuclear accumulation. We will discuss…”
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Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response by Porter, Joshua R., Fisher, Brian E., Baranello, Laura, Liu, Julia C., Kambach, Diane M., Nie, Zuqin, Koh, Woo Seuk, Luo, Ji, Stommel, Jayne M., Levens, David, Batchelor, Eric

“…In response to stresses, cells often halt normal cellular processes, yet stress-specific pathways must bypass such inhibition to generate effective responses…”
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LXRβ controls glioblastoma cell growth, lipid balance, and immune modulation independently of ABCA1 by Patel, Deven, Ahmad, Fahim, Kambach, Diane M., Sun, Qian, Halim, Alan S., Kramp, Tamalee, Camphausen, Kevin A., Stommel, Jayne M.

“…Cholesterol is a critical component of membranes and a precursor for hormones and other signaling molecules. Previously, we showed that unlike astrocytes,…”
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Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase by Inuzuka, Hiroyuki, Tseng, Alan, Gao, Daming, Zhai, Bo, Zhang, Qing, Shaik, Shavali, Wan, Lixin, Ang, Xiaolu L, Mock, Caroline, Yin, Haoqiang, Stommel, Jayne M, Gygi, Steven, Lahav, Galit, Asara, John, Xiao, Zhi-Xiong Jim, Kaelin, Jr, William G, Harper, J Wade, Wei, Wenyi

“…Mdm2 is the major negative regulator of the p53 pathway. Here, we report that Mdm2 is rapidly degraded after DNA damage and that phosphorylation of Mdm2 by…”
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Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation by Stommel, Jayne M, Wahl, Geoffrey M

“…p53 activation prevents the proliferation of genetically unstable cells. Conversely, p53 antagonism by its transcriptional target, the E3 ubiquitin ligase…”
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Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example by Eke, Iris, Makinde, Adeola Y, Aryankalayil, Molykutty J, Sandfort, Veit, Palayoor, Sanjeewani T, Rath, Barbara H, Liotta, Lance, Pierobon, Mariaelena, Petricoin, Emanuel F, Brown, Matthew F, Stommel, Jayne M, Ahmed, Mansoor M, Coleman, C Norman

“…Implementing targeted drug therapy in radio-oncologic treatment regimens has greatly improved the outcome of cancer patients. However, the efficacy of…”
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Exceptional Response to Trastuzumab Deruxtecan in a Patient With Recurrent Ovarian Clear Cell Carcinoma With Human Epidermal Growth Factor Receptor 2 Expression by Kong, Ben L, Stommel, Jayne M, Keck, Jamie M, Kilburn, David, Streblow, Aaron, Egger, Julian, Creason, Allison L, Suciu, Christopher G, Guimaraes, Alexander R, Corless, Christopher L, Mills, Gordon B, Pejovic, Tanja B

“…Case report of a HER2-expressed ovarian clear cell carcinoma with exceptional response to trastuzumab deruxtecan…”
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An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer by Johnson, Brett E., Creason, Allison L., Stommel, Jayne M., Keck, Jamie M., Parmar, Swapnil, Betts, Courtney B., Blucher, Aurora, Boniface, Christopher, Bucher, Elmar, Burlingame, Erik, Camp, Todd, Chin, Koei, Eng, Jennifer, Estabrook, Joseph, Feiler, Heidi S., Heskett, Michael B., Hu, Zhi, Kolodzie, Annette, Kong, Ben L., Labrie, Marilyne, Lee, Jinho, Leyshock, Patrick, Mitri, Souraya, Patterson, Janice, Riesterer, Jessica L., Sivagnanam, Shamilene, Somers, Julia, Sudar, Damir, Thibault, Guillaume, Weeder, Benjamin R., Zheng, Christina, Nan, Xiaolin, Thompson, Reid F., Heiser, Laura M., Spellman, Paul T., Thomas, George, Demir, Emek, Chang, Young Hwan, Coussens, Lisa M., Guimaraes, Alexander R., Corless, Christopher, Goecks, Jeremy, Bergan, Raymond, Mitri, Zahi, Mills, Gordon B., Gray, Joe W.

“…Mechanisms of therapeutic resistance and vulnerability evolve in metastatic cancers as tumor cells and extrinsic microenvironmental influences change during…”
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A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking by Stommel, Jayne M., Marchenko, Natalie D., Jimenez, Gretchen S., Moll, Ute M., Hope, Thomas J., Wahl, Geoffrey M.

“…Appropriate subcellular localization is crucial for regulating p53 function. We show that p53 export is mediated by a highly conserved leucine‐rich nuclear…”
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Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma by Kambach, Diane M, Halim, Alan S, Cauer, A Gesine, Sun, Qian, Tristan, Carlos A, Celiku, Orieta, Kesarwala, Aparna H, Shankavaram, Uma, Batchelor, Eric, Stommel, Jayne M

“…A hallmark of cellular transformation is the evasion of contact-dependent inhibition of growth. To find new therapeutic targets for glioblastoma, we looked for…”
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Disabled cell density sensing leads to dysregulated cholesterol synthesis in glioblastoma by Kambach, Diane M., Halim, Alan S., Cauer, A. Gesine, Sun, Qian, Tristan, Carlos A., Celiku, Orieta, Kesarwala, Aparna H., Shankavaram, Uma, Batchelor, Eric, Stommel, Jayne M.

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